Publications

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Journal Article
Refaat, M., A. M. Abdullatif, M. M. Hamza, T. A. Macky, M. H. El-Agha, G. Ragab, and M. M. Soliman, "Monthly Intravitreal Infliximab in Behçet's Disease Active Posterior Uveitis: A Long-Term Safety Study.", Retina (Philadelphia, Pa.), 2020. Abstract
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El-Gendy, H., R. M. El-Gohary, S. Mahfouz, H. M. A. Ahmed, D. M. El Demerdash, and G. Ragab, "Multifocal avascular necrosis in a patient with refractory immune thrombocytopenia and antiphospholipid antibodies; case report and review of literature", Platelets, vol. 30, issue 5: Taylor & Francis, pp. 664-671, 2019. Abstract
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El-Gendy, H., R. M. El-Gohary, S. Mahfouz, H. M. A. Ahmed, D. M. El Demerdash, and G. Ragab, "Multifocal avascular necrosis in a patient with refractory immune thrombocytopenia and antiphospholipid antibodies; case report and review of literature", Platelets, vol. 30, issue 5: Taylor and Francis Ltd, pp. 664 - 671, 2019. Abstracthttps://scholar.google.com.eg/citations?hl=en&user=7L5p7RYAAAAJ
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El-Gendy, H., R. M. El-Gohary, S. Mahfouz, H. M. A. Ahmed, D. M. El Demerdash, and G. Ragab, "Multifocal avascular necrosis in a patient with refractory immune thrombocytopenia and antiphospholipid antibodies; case report and review of literature.", Platelets, pp. 1-8, 2018 Oct 29. Abstract

Avascular necrosis (AVN) is a devastating condition that is rarely reported in patients with immune thrombocytopenia (ITP). Treatment with steroids remains a major risk factor for developing AVN. However, the incidence of AVN in patients with ITP requiring corticosteroid therapy is much less than that observed with other clinical conditions requiring corticosteroids. ITP is a bleeding disorder but can be also be a pro-thrombotic state via different mechanisms and thus could result in AVN. Among the possible causes of this pro-thrombotic state is the presence of antiphospholipid antibodies (aPLs). In this case, we report a patient with refractory ITP who developed multifocal AVN around the time she acquired new aPLs. We also discuss different mechanisms by which risk of thrombosis is increased in ITP and the relationship between ITP, aPLs and antiphospholipid syndrome.

Ragab, G., H. El-Gendy, and R. M. El-Gohary, Musculoskeletal Disorders and Treatment, , 2017. Abstract
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Quartuccio, L., L. Corazza, M. Ramos-Casals, S. Retamozo, G. M. Ragab, G. Ferraccioli, E. Gremese, A. Tzioufas, M. Voulgarelis, D. Vassilopoulos, et al., "OP0274 Cryoglobulinemic Vasculitis and Primary sjögren's Syndrome are Independent Risk Factors for Lymphoma in a Large Worldwide Population of Patients with Positive Serum Cryoglobulins", Annals of the Rheumatic Diseases, vol. 74, issue Suppl 2, pp. 175-176, June 1, 2015. Abstracthttps://scholar.google.com.eg/citations?hl=en&user=7L5p7RYAAAAJ

Background Serum cryoglobulins (SC) may be found in many diseases (1), and the presence of serum cryoglobulins is a known risk factor for lymphoma evolution in some non malignant diseases.Objectives The aim of this study was to distiguish the role of cryoglobulinemic vasculitis (CV), classified according to the recent validated criteria (1,2), and primary Sjögren's syndrome (pSS) as risk factors of lymphoma in patients positive serum cryoglobulins. Importantly, SC, CV and pSS may occur together.Methods 950 charts from consecutive patients with positive SC were evaluated. Patients carrying both pSS and HCV infection, as well as incomplete charts, were excluded.Results 657 patients with SC were selected, 374 with CV and 283 without CV, according to the published criteria (2,3). PSS, classified according to the American-European Group Criteria was present in 96 patients (44 with CV, 52 without). Lymphoma was reported in 61/657 (9.8%) patients with SC. Among them, CV was present in 44/61 (72,1%; 14 also with pSS), and pSS in 17/61 (27,9%; and 14/17 had CV). Patients with SC with CV showed an higher prevalence of lymphoma than patients with SC without CV (44/374, 11.5% vs.17/283, 6.3%; p=0.025, OR=1.93 [95%IC: 1.08-3.39]. Patients with pSS, SC and CV also showed a higher prevalence of lymphoma than patients with pSS, SC but without CV (14/44, 31.8% vs. 3/52, 7.4%; p=0.001, OR=7.62 [95%CI 2.02-28.74]. CV and pSS were confirmed as independent risk factor for lymphoma by multivariate analysis (OR 2,18 95%CI 1,18-3,83, p=0,012; OR 2,65 95%CI 1,04-6,76, p=0,042, respectively). Infection by the hepatitis C virus (HCV) was detected in 467/561 (83,2%) patients with SC without pSS, and did not statistically predispose to lymphoma when associated with CV in this subset (p=1,0).Conclusions Cryoglobulinemic vasculitis and pSS are independent risk factors for lymphoma in patients with evidence of SC. Patients with both the conditions (CV and pSS) have the highest risk. In the follow-up of SC positive patients, a very high attention should be deserved to pSS, in particular when CV is present.ReferencesDe Vita S, et al. Ann Rheum Dis. 2011; 2) Quartuccio L, et al. Rheumatology (Oxford). 2014Disclosure of Interest None declared

Ragab, M., "Oral Direct Anticoagulants in Thrombosis Management in Anti-Phospholipid Syndrome: Unanswered Questions", J Hematol Thrombo Dis, vol. 3, issue 208: http://www.esciencecentral.org/journals/oral-direct-anticoagulants-in …, 2015. Abstract
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Hussein, M. A., M. I. Ellawindi, and G. Ragab, "Performance of classification criteria for Behcet's disease in an Egyptian cohort", Indian Journal of Rheumatology, vol. 12, issue 3: Medknow Publications, pp. 152, 2017. Abstract
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Hussein, M., M. Ellawindi, and G. Ragab, "Performance of classification criteria for Behcet's disease in an Egyptian cohort", Indian Journal of Rheumatology, vol. 12, issue 3: Medknow Publications, pp. 152 - 155, 2017. Abstracthttps://scholar.google.com.eg/citations?hl=en&user=7L5p7RYAAAAJ
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Goubran, H., J. Seghatchian, W. Sabry, G. Ragab, and T. Burnouf, "Platelet and extracellular vesicles in COVID-19 infection and its vaccines", Transfusion and Apheresis Science, vol. 61, issue 3: Elsevier Ltd, 2022. Abstracthttps://scholar.google.com.eg/citations?hl=en&user=7L5p7RYAAAAJ
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Fayed, A., M. T. Hegazy, L. Biard, M. Vieira, T. El Shabony, D. Saadoun, M. Casato, M. Visentini, G. Ragab, and P. Cacoub, "Relapse of Hepatitis C Virus Cryoglobulinemic Vasculitis after Sustained Viral Response after Interferon-Free Direct-Acting Antivirals", American Journal of Gastroenterology, vol. 117, issue 4: Wolters Kluwer Health, pp. 627 - 636, 2022. Abstracthttps://scholar.google.com.eg/citations?hl=en&user=7L5p7RYAAAAJ
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Al Saleh, J., G. Ragab, P. Nash, H. Halabi, A. Laatar, A. M. El-Sayed Yousef, H. Ehsouna, and M. Hammoudeh, "Rheumatoid arthritis in the Middle East and Africa: are we any closer to optimising its management?", Clinical rheumatology, vol. 34, issue 1, pp. 1-8, 2015 Jan. Abstract
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Al Saleh, J., G. Ragab, P. Nash, H. Halabi, A. Laatar, A. M. El-Sayed Yousef, H. Ehsouna, and M. Hammoudeh, "Rheumatoid arthritis in the Middle East and Africa: are we any closer to optimising its management?", Clinical Rheumatology, vol. 34, issue 1: Springer London, 2015. Abstracthttps://scholar.google.com.eg/citations?hl=en&user=7L5p7RYAAAAJ
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Treppo, E., L. Quartuccio, G. Ragab, and S. De Vita, "Rheumatologic manifestations of Hepatitis C Virus", Minerva Medica, vol. 112, issue 2: Edizioni Minerva Medica, pp. 201 - 214, 2021. Abstracthttps://scholar.google.com.eg/citations?hl=en&user=7L5p7RYAAAAJ
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Treppo, E., L. Quartuccio, G. Ragab, and S. De Vita, "Rheumatologic manifestations of Hepatitis C Virus.", Minerva Medica, 2020. Abstract
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Goubran, H., J. Stakiw, J. Seghatchian, G. Ragab, and T. Burnouf, "SARS-CoV-2 and cancer: The intriguing and informative cross-talk", Transfusion and Apheresis Science: Elsevier Ltd, 2022. Abstracthttps://scholar.google.com.eg/citations?hl=en&user=7L5p7RYAAAAJ
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De Vita, S., L. Quartuccio, M. Isola, L. Corazza, M. Ramos-Casals, S. Retamozo, G. Ragab, N. Zoheir, M. M. El Menyawi, and M. Salem, "SAT0175 Results of the Classification Criteria for Cryoglobulinemic Vasculitis Validation Study", Annals of the Rheumatic Diseases, vol. 72, issue Suppl 3: BMJ Publishing Group Ltd, pp. A640-A641, 2013. Abstract
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Ragab, G., M. T. Hegazy, M. Ali, M. R. E. Abdel-Halim, and X. Puéchal, "Three Patterns of Cutaneous Involvement in Granulomatosis with Polyangiitis", Journal of Advanced Research, vol. 24: Elsevier, pp. 311-315, 2020. Abstract
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Ragab, G., M. T. Hegazy, M. Ali, M. R. E. Abdel-Halim, and X. Puéchal, "Three Patterns of Cutaneous Involvement in Granulomatosis with Polyangiitis", Journal of Advanced Research, vol. 24: Elsevier B.V., pp. 311 - 315, 2020. Abstracthttps://scholar.google.com.eg/citations?hl=en&user=7L5p7RYAAAAJ
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Elbendary, A., M. R. E. Abdel-Halim, and G. Ragab, "Updates in cutaneous manifestations of systemic vasculitis", Current opinion in rheumatology, vol. 34, issue 1: NLM (Medline), pp. 25 - 32, 2022. Abstracthttps://scholar.google.com.eg/citations?hl=en&user=7L5p7RYAAAAJ
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Quartuccio, L., M. Isola, L. Corazza, M. Ramos-Casals, S. Retamozo, G. M. Ragab, M. N. Zoheir, M. A. - M. El-Menyawi, M. N. Salem, and D. Sansonno, "Validation of the classification criteria for cryoglobulinaemic vasculitis", Rheumatology, vol. 53, issue 12: Oxford University Press, pp. 2209-2213, 2014. Abstract
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Quartuccio, L., M. Isola, L. Corazza, M. Ramos-Casals, S. Retamozo, G. M. Ragab, M. Naguib Zoheir, M. - M. El-Menyawi, M. N. Salem, D. Sansonno, et al., "Validation of the classification criteria for cryoglobulinaemic vasculitis", Rheumatology (United Kingdom), vol. 53, issue 12: Oxford University Press, pp. 2209 - 2213, 2014. Abstracthttps://scholar.google.com.eg/citations?hl=en&user=7L5p7RYAAAAJ
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Quartuccio, L., M. Isola, L. Corazza, M. Ramos-Casals, S. Retamozo, G. M. Ragab, M. N. Zoheir, M. A. - M. El-Menyawi, M. N. Salem, D. Sansonno, et al., "Validation of the classification criteria for cryoglobulinaemic vasculitis.", Rheumatology (Oxford, England), vol. 53, issue 12, pp. 2209-13, 2014 Dec. Abstract

OBJECTIVE: The aim of this study was to validate the classification criteria for cryoglobulinaemic vasculitis (CV).

METHODS: Twenty-three centres were involved. New patients with CV (group A) and controls, i.e. subjects with serum cryoglobulins but lacking CV based on the gold standard of clinical judgment (group B) and subjects without cryoglobulins but with clinical features that can be observed in the course of CV (group C), were studied. Positivity of serum cryoglobulins was necessary for CV classification. Sensitivity and specificity of the criteria were calculated by comparing group A vs group B. The group A vs group C comparison was done to demonstrate the possible diagnostic utility of the criteria.

RESULTS: The study included 268 patients in group A, 182 controls in group B and 193 controls in group C (small vessel vasculitis, 51.8%). The questionnaire (at least 2/3 positive answers) showed 89.0% sensitivity and 93.4% specificity; the clinical item (at least 3/4 clinical involvement) showed 75.7% sensitivity and 89.0% specificity and the laboratory item (at least 2/3 laboratory data) showed 80.2% sensitivity and 62.4% specificity. The sensitivity and specificity of the classification criteria (at least 2/3 positive items) were 89.9% and 93.5%, respectively. The comparison of group A with group C demonstrated the clinical utility of the criteria in differentiating CV from CV mimickers.

CONCLUSION: Classification criteria for CV were validated in a second, large, international study confirming good sensitivity and specificity in a complex systemic disease.

Ragab, G., and M. A. Hussein, "Vasculitic syndromes in hepatitis C virus: A review", Journal of Advanced Research, vol. 8, no. 2, pp. 99 - 111, 2017. Abstracthttps://scholar.google.com.eg/citations?hl=en&user=7L5p7RYAAAAJ
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Ragab, G., and M. A. Hussein, "Vasculitic syndromes in hepatitis C virus: A review", Journal of advanced research, vol. 8, issue 2: Elsevier, pp. 99-111, 2017. Abstract
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Ragab, G., and M. A. Hussein, "Vasculitic syndromes in hepatitis C virus: A review", Journal of Advanced Research, vol. 8, issue 2: Elsevier B.V., pp. 99 - 111, 2017. Abstracthttps://scholar.google.com.eg/citations?hl=en&user=7L5p7RYAAAAJ
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Miscellaneous
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Ragab, G., P. T. Atkinson, and M. L. Stoll, The Microbiome in Rheumatic Diseases and Infection, : Springer, 2018. Abstract
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Cacoub, P., S. Pol, D. Thabut, C. Hezode, L. Alric, C. Comarmond, G. Ragab, L. Quatuccio, M. Hegazy, and T. Poynard, OP0235 Interferon-free antivirals for hepatitis c virus-associated cryoglobulinemia vasculitis: a long-term follow-up study, : BMJ Publishing Group Ltd, 2018. Abstract
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Quartuccio, L., L. Corazza, M. Ramos-Casals, S. Retamozo, G. M. Ragab, G. Ferraccioli, E. Gremese, A. Tzioufas, M. Voulgarelis, and D. Vassilopoulos, OP0274 Cryoglobulinemic Vasculitis and Primary sjögren's Syndrome are Independent Risk Factors for Lymphoma in a Large Worldwide Population of Patients with Positive Serum Cryoglobulins, : BMJ Publishing Group Ltd, 2015. Abstract
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Goubran, H., G. Ragab, and S. Hassouna, Precision Anticoagulation Medicine: A Practical Guide, : Springer Nature, 2019. Abstract
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Al Saleh, J., G. Ragab, P. Nash, H. Halabi, A. Laatar, A. E. - S. M. Yousef, H. Ehsouna, and M. Hammoudeh, Rheumatoid arthritis in the Middle East and Africa: are we any closer to optimising its management?, : Springer London, 2015. Abstract
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Tourism