Publications

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2016
El-Gendy, H., R. M. El-Gohary, K. S. Shohdy, and G. Ragab, "Leprosy Masquerading as Systemic Rheumatic Diseases", Journal of Clinical Rheumatology, vol. 22, issue 5: Lippincott Williams and Wilkins, pp. 264 - 271, 2016. Abstracthttps://scholar.google.com.eg/citations?hl=en&user=7L5p7RYAAAAJ
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El-Fishawy, H., G. Saadi, M. Hassaballa, M. Hussein, W. Doss, G. Ragab, and R. Barsoum, "Antiviral treatment prioritization in HCV-infected patients with extrahepatic manifestations–An Egyptian perspective", Journal of advanced research, vol. 7, issue 3: Elsevier, pp. 391-402, 2016. Abstract
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Hegab, M. M., A. F. Abdelwahab, A. E. - S. M. Yousef, M. N. Salem, W. El-Baz, S. Abdelrhman, F. Elshabacy, A. Alhefny, W. Abouraya, and S. M. Ibrahim, "CD28 and PTPN22 are associated with susceptibility to rheumatoid arthritis in Egyptians", Human immunology, vol. 77, issue 6: Elsevier, pp. 522-526, 2016. Abstract
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M Fawzy, A Edrees, O. E. A. R. H. A. G., "Gastrointestinal manifestations in systemic lupus erythematosus", Lupus, 2016. Abstract
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Ferri, C., M. Ramos-Casals, A. L. Zignego, L. Arcaini, D. Roccatello, A. Antonelli, D. Saadoun, A. C. Desbois, M. Sebastiani, and M. Casato, "International diagnostic guidelines for patients with HCV-related extrahepatic manifestations. A multidisciplinary expert statement", Autoimmunity Reviews, vol. 15, issue 12: Elsevier, pp. 1145-1160, 2016. Abstract
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Hamza, M. M. E., T. A. Macky, M. K. Sidky, G. Ragab, and M. M. Soliman, "Intravitreal infliximab in refractory uveitis in Behçet's disease: a safety and efficacy clinical study", Retina, vol. 36, issue 12: LWW, pp. 2399-2408, 2016. Abstract
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El-Gendy, H., R. M. El-Gohary, K. S. Shohdy, and G. Ragab, "Leprosy masquerading as systemic rheumatic diseases", JCR: Journal of Clinical Rheumatology, vol. 22, issue 5: LWW, pp. 264-271, 2016. Abstract
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Hegazy, M. T., M. A. Hussein, L. Quartuccio, M. Fawzy, N. Zoheir, M. I. Ellawindi, M. Bond, C. Mazzaro, A. E. Ray, and M. E. S. El Raziky, "Treatment of cryoglobulinemic vasculitis with sofosbuvir in four combination protocols", ARTHRITIS & RHEUMATOLOGY, vol. 68: WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2016. Abstract
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2015
Quartuccio, L., L. Corazza, M. Ramos-Casals, S. Retamozo, G. M. Ragab, G. Ferraccioli, E. Gremese, A. Tzioufas, M. Voulgarelis, D. Vassilopoulos, et al., "OP0274 Cryoglobulinemic Vasculitis and Primary sjögren's Syndrome are Independent Risk Factors for Lymphoma in a Large Worldwide Population of Patients with Positive Serum Cryoglobulins", Annals of the Rheumatic Diseases, vol. 74, issue Suppl 2, pp. 175-176, June 1, 2015. Abstracthttps://scholar.google.com.eg/citations?hl=en&user=7L5p7RYAAAAJ

Background Serum cryoglobulins (SC) may be found in many diseases (1), and the presence of serum cryoglobulins is a known risk factor for lymphoma evolution in some non malignant diseases.Objectives The aim of this study was to distiguish the role of cryoglobulinemic vasculitis (CV), classified according to the recent validated criteria (1,2), and primary Sjögren's syndrome (pSS) as risk factors of lymphoma in patients positive serum cryoglobulins. Importantly, SC, CV and pSS may occur together.Methods 950 charts from consecutive patients with positive SC were evaluated. Patients carrying both pSS and HCV infection, as well as incomplete charts, were excluded.Results 657 patients with SC were selected, 374 with CV and 283 without CV, according to the published criteria (2,3). PSS, classified according to the American-European Group Criteria was present in 96 patients (44 with CV, 52 without). Lymphoma was reported in 61/657 (9.8%) patients with SC. Among them, CV was present in 44/61 (72,1%; 14 also with pSS), and pSS in 17/61 (27,9%; and 14/17 had CV). Patients with SC with CV showed an higher prevalence of lymphoma than patients with SC without CV (44/374, 11.5% vs.17/283, 6.3%; p=0.025, OR=1.93 [95%IC: 1.08-3.39]. Patients with pSS, SC and CV also showed a higher prevalence of lymphoma than patients with pSS, SC but without CV (14/44, 31.8% vs. 3/52, 7.4%; p=0.001, OR=7.62 [95%CI 2.02-28.74]. CV and pSS were confirmed as independent risk factor for lymphoma by multivariate analysis (OR 2,18 95%CI 1,18-3,83, p=0,012; OR 2,65 95%CI 1,04-6,76, p=0,042, respectively). Infection by the hepatitis C virus (HCV) was detected in 467/561 (83,2%) patients with SC without pSS, and did not statistically predispose to lymphoma when associated with CV in this subset (p=1,0).Conclusions Cryoglobulinemic vasculitis and pSS are independent risk factors for lymphoma in patients with evidence of SC. Patients with both the conditions (CV and pSS) have the highest risk. In the follow-up of SC positive patients, a very high attention should be deserved to pSS, in particular when CV is present.ReferencesDe Vita S, et al. Ann Rheum Dis. 2011; 2) Quartuccio L, et al. Rheumatology (Oxford). 2014Disclosure of Interest None declared

Al Saleh, J., G. Ragab, P. Nash, H. Halabi, A. Laatar, A. M. El-Sayed Yousef, H. Ehsouna, and M. Hammoudeh, "Rheumatoid arthritis in the Middle East and Africa: are we any closer to optimising its management?", Clinical rheumatology, vol. 34, issue 1, pp. 1-8, 2015 Jan. Abstract
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Al Saleh, J., G. Ragab, P. Nash, H. Halabi, A. Laatar, A. M. El-Sayed Yousef, H. Ehsouna, and M. Hammoudeh, "Rheumatoid arthritis in the Middle East and Africa: are we any closer to optimising its management?", Clinical Rheumatology, vol. 34, issue 1: Springer London, 2015. Abstracthttps://scholar.google.com.eg/citations?hl=en&user=7L5p7RYAAAAJ
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Quartuccio, L., L. Corazza, M. Ramos-Casals, S. Retamozo, G. M. Ragab, G. Ferraccioli, E. Gremese, A. Tzioufas, M. Voulgarelis, and D. Vassilopoulos, OP0274 Cryoglobulinemic Vasculitis and Primary sjögren's Syndrome are Independent Risk Factors for Lymphoma in a Large Worldwide Population of Patients with Positive Serum Cryoglobulins, : BMJ Publishing Group Ltd, 2015. Abstract
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Ragab, M., "Oral Direct Anticoagulants in Thrombosis Management in Anti-Phospholipid Syndrome: Unanswered Questions", J Hematol Thrombo Dis, vol. 3, issue 208: http://www.esciencecentral.org/journals/oral-direct-anticoagulants-in …, 2015. Abstract
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Al Saleh, J., G. Ragab, P. Nash, H. Halabi, A. Laatar, A. E. - S. M. Yousef, H. Ehsouna, and M. Hammoudeh, Rheumatoid arthritis in the Middle East and Africa: are we any closer to optimising its management?, : Springer London, 2015. Abstract
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2014
Quartuccio, L., M. Isola, L. Corazza, M. Ramos-Casals, S. Retamozo, G. M. Ragab, M. N. Zoheir, M. A. - M. El-Menyawi, M. N. Salem, D. Sansonno, et al., "Validation of the classification criteria for cryoglobulinaemic vasculitis.", Rheumatology (Oxford, England), vol. 53, issue 12, pp. 2209-13, 2014 Dec. Abstract

OBJECTIVE: The aim of this study was to validate the classification criteria for cryoglobulinaemic vasculitis (CV).

METHODS: Twenty-three centres were involved. New patients with CV (group A) and controls, i.e. subjects with serum cryoglobulins but lacking CV based on the gold standard of clinical judgment (group B) and subjects without cryoglobulins but with clinical features that can be observed in the course of CV (group C), were studied. Positivity of serum cryoglobulins was necessary for CV classification. Sensitivity and specificity of the criteria were calculated by comparing group A vs group B. The group A vs group C comparison was done to demonstrate the possible diagnostic utility of the criteria.

RESULTS: The study included 268 patients in group A, 182 controls in group B and 193 controls in group C (small vessel vasculitis, 51.8%). The questionnaire (at least 2/3 positive answers) showed 89.0% sensitivity and 93.4% specificity; the clinical item (at least 3/4 clinical involvement) showed 75.7% sensitivity and 89.0% specificity and the laboratory item (at least 2/3 laboratory data) showed 80.2% sensitivity and 62.4% specificity. The sensitivity and specificity of the classification criteria (at least 2/3 positive items) were 89.9% and 93.5%, respectively. The comparison of group A with group C demonstrated the clinical utility of the criteria in differentiating CV from CV mimickers.

CONCLUSION: Classification criteria for CV were validated in a second, large, international study confirming good sensitivity and specificity in a complex systemic disease.

Quartuccio, L., M. Isola, L. Corazza, M. Ramos-Casals, S. Retamozo, G. M. Ragab, M. Naguib Zoheir, M. - M. El-Menyawi, M. N. Salem, D. Sansonno, et al., "Validation of the classification criteria for cryoglobulinaemic vasculitis", Rheumatology (United Kingdom), vol. 53, issue 12: Oxford University Press, pp. 2209 - 2213, 2014. Abstracthttps://scholar.google.com.eg/citations?hl=en&user=7L5p7RYAAAAJ
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Ragab, G., "Vasculitic manifestations in the gastrointestinal tract", Oxford Textbook of Vasculitis: Oxford University Press, 2014.
Quartuccio, L., M. Isola, L. Corazza, M. Ramos-Casals, S. Retamozo, G. M. Ragab, M. N. Zoheir, M. A. - M. El-Menyawi, M. N. Salem, and D. Sansonno, "Validation of the classification criteria for cryoglobulinaemic vasculitis", Rheumatology, vol. 53, issue 12: Oxford University Press, pp. 2209-2213, 2014. Abstract
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Ragab, G., "Vasculitic manifestations in the gastrointestinal tract", Oxford Textbook of Vasculitis: Oxford University Press, pp. 179-195, 2014. Abstract
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2013
Hussein, M., A. El-Hindawi, and G. Ragab, "Everolimus in Erdheim–Chester disease", The Egyptian Journal of Internal Medicine, vol. 25, issue 3, pp. 159 - 163, 2013/9/1. Abstracthttps://scholar.google.com.eg/citations?hl=en&user=7L5p7RYAAAAJ

A 43-year-old man presented with bony pains, repeated pathological fractures with overlying skin ulcerations, and forearm and chest wall swellings. Investigations led to the diagnosis of Erdheim–Chester disease. Treatment with low-dose prednisolone, oral everolimus, and zoledronic acid was started, with a marked improvement in his condition.

Abdel Badaee, H., A. Edrees, S. Amin, M. Elamir, and G. Ragab, "Activated protein C resistance in Behcet's disease", Thrombosis Journal, vol. 11, issue 1, 2013. Abstracthttps://scholar.google.com.eg/citations?hl=en&user=7L5p7RYAAAAJ
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Abdel Badaee, H., A. Edrees, S. Amin, M. El Amir, and G. Ragab, "Activated protein C resistance in Behcet's disease.", Thrombosis journal, vol. 11, issue 1, pp. 17, 2013. Abstract

Behcet's disease is a chronic multi-system disorder of unknown etiology with protean manifestations. Venous thromboembolism is more common than arterial thrombosis, with deep vein thrombosis being the most frequent. Endothelial dysfunction resulting from vascular inflammation is considered to be an important factor of thrombosis, although the endothelial injury itself cannot completely explain the hypercoagulable state of the disease because other vasculitis syndromes do not increase the risk of thrombosis. The aim of this study is to evaluate the prevalence of activated protein C resistance (APC-R) in Egyptian patients with Behcet's disease. Also, to detect hyperhomocysteinemia in selected cases (with vascular complications) to assess their relationship with thromboembolic complications. The APC resistance ratio mean in the group of patients with vascular involvement was 2.6 ± 0.8 which was less than the group with no vascular involvement 2.8 ± 0.6, with non- significant P-value (0.5). There was more incidence of ocular lesions in the group of patients with high homocysteine level than the group of patients with normal homocytsteine level with significant P-value (0.08).

Abdel Badaee, H., A. Edrees, S. Amin, M. El Amir, and G. Ragab, "Activated protein C resistance in Behcet’s disease", Thrombosis journal, vol. 11, issue 1: BioMed Central, pp. 1-5, 2013. Abstract
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Hussein, M. A., A. El-Hindawi, and G. Ragab, "Everolimus in Erdheim–Chester disease", The Egyptian Journal of Internal Medicine, vol. 25, issue 3: SpringerOpen, pp. 159-163, 2013. Abstract
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De Vita, S., L. Quartuccio, M. Isola, L. Corazza, M. Ramos-Casals, S. Retamozo, G. Ragab, N. Zoheir, M. M. El Menyawi, M. Salem, et al., "RESULTS OF THE CLASSIFICATION CRITERIA FOR CRYOGLOBULINEMIC VASCULITIS VALIDATION STUDY", ANNALS OF THE RHEUMATIC DISEASES, vol. 72: BMJ PUBLISHING GROUP BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND, pp. 640–641, 2013. Abstract
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De Vita, S., L. Quartuccio, M. Isola, L. Corazza, M. Ramos-Casals, S. Retamozo, G. Ragab, N. Zoheir, M. M. El Menyawi, and M. Salem, "SAT0175 Results of the Classification Criteria for Cryoglobulinemic Vasculitis Validation Study", Annals of the Rheumatic Diseases, vol. 72, issue Suppl 3: BMJ Publishing Group Ltd, pp. A640-A641, 2013. Abstract
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Quartuccio, L., M. Isola, L. Corazza, S. Retamozo, M. A. - M. El-Menyawi, E. Gremese, M. Sebastiani, N. Pipitone, T. Urraro, V. Conteduca, et al., "Validation Study Of The International Classification Criteria For The Cryoglobulinemic Vasculitis", ARTHRITIS AND RHEUMATISM, vol. 65, pp. S1123–S1124, 2013. Abstract
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Luca, Q., I. Miriam, C. Laura, R. Soledad, M. A. M. El Menyawi, G. Elisa, M. Sebastiani, P. Nicolo, U. Teresa, and C. Vincenza, "Validation Study Of The International Classification Criteria For The Cryoglobulinemic Vasculitis", ACR 2013 ANNUAL MEETING, vol. 65, pp. S1123-S1124, 2013. Abstract
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2012
Ragab, G., M. A. El-Ghobary, R. M. Elgohary, and others, "The importance of using ultrasonography in knee osteoarthritis", The Egyptian Journal of Internal Medicine, vol. 24, no. 3: Medknow Publications, pp. 93, 2012. Abstract
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Ragab, G., M. A. El-Ghobary, and R. M. Elgohary, "The importance of using ultrasonography in knee osteoarthritis", The Egyptian Journal of Internal Medicine, vol. 24, issue 3: SpringerOpen, pp. 93-96, 2012. Abstract
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2008
Ragab, G., "Chapter 15: Vasculitic manifestations in the gastrointestinal tract", Vasculitis: Oxford University Press, pp. 181-198, 2008. Abstract
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2007
DeVore, A. E., J. L. Jorizzo, N. Vigneswaran, B. K. Rodu, S. Onal, S. C. Foster, S. K. Frankel, M. I. Schwarz, S. J. Oh, G. Ragab, et al., "Clinical manifestations common to vasculitis", Vasculitis: Oxford University Press, pp. 115, 2007. Abstract
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DeVore, A. E., J. L. Jorizzo, N. Vigneswaran, B. K. Rodu, S. Onal, S. C. Foster, S. K. Frankel, M. I. Schwarz, S. J. Oh, and G. Ragab, "Clinical manifestations common to vasculitis", Vasculitis: Oxford University Press, pp. 115, 2007. Abstract
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