Beneficial effects of capozide on carbohydrate and lipid metabolism

Gaafar, K. M., H. taha, and J. seid, "Beneficial effects of capozide on carbohydrate and lipid metabolism", Proceedings of the egyptian Academy of Sciences, vol. 46, pp. 41-56, 1996.


capozide was administered in a dose of 1.012 mg/200g rat body weight once a day for 4 weeks to normal and diabetic rats. It had no effects on serum potassium urea or creatinine. No increase in lipid concentration to negate its beneficial hypotensive effect, was noted. Form oral glucose tolerance test, it was calculated that the drug improved glucose tolerance concomitant with the increased beta cell function and peripheral insulin response.
The interaction between the two components of capozide, captopril an angiotensin converting enzyme inhibitor, and hydrochlorothiazide, a diuretic, is discussed in regards to carbohydrate and lipid homeostasis.

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