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Tebi, I. E., E. Baligh, H. Gamal, Z. Ashour, G. Youssef, A. Shehata, and M. Mokhtar, "Familial history of hypertension as a predictor of increased arterial stiffness", European Heart Journal, vol. 34, issue Suppl_1, 2013.
Ibrahim, M. M., W. El-Aroussy, H. Riz, H. Kandil, A. Farrag, K. Said, G. Youssef, A. Abdelwahab, O. Awwad, O. Elkhashab, et al., "The Egyptian Hypertension Society EGYPTIAN HYPERTENSION GUIDELINES", Egyptian Heart Journal, vol. 66, pp. 79-132, 2014. egyptian_htn_guidelines_publication.pdf
Shalaby, A., A. A. Ibrahim, H. Elghobary, and G. Youssef, "Detection of Micro RNA-499 In Acute Myocardial Infarction, Significance Of A New Marker.", Research Journal of Pharmaceutical, Biological and Chemical Sciences, vol. 8, issue 1, pp. 1480-1485, 2017. detection_of_mir_499_in_acute__myocardial_infarction_significance_of_a_new_marker_1.pdf
Youssef, G., I. Tebi, D. Osama, A. Shehahta, E. Baligh, Z. Ashour, and H. Gamal, "Familial history of hypertension as a predictor of increased arterial stiffness in normotensive offspring", Egyptian Heart Journal, vol. 69, pp. 37-44, 2017.
Youssef, G., B. Zayed, mohammed momtaz, A. Roshdy, and M. Shaaban, "Lung ultrasound and bioimpedance in assessment of volume status of hemodialysis patients", Kasr Al Ainy Medical Journal, vol. 23, issue 1, pp. 18-23, 2017. kamj_35_16r2_paper_1.pdf
Youssef, G., A. Kamal, R. Diab, and M. A. Hamid, "P5825Intravenous iron therapy in acute decompensated heart failure patients with iron deficiency anaemia", European Heart Journal, vol. 38, issue suppl_1, 2017.
Youssef, G., H. Kassem, O. Ameen, A. H. Taaban, and H. Rizk, "Pre-hospital and hospital delay in patients with non-ST elevation acute coronary syndromes in tertiary care", Egyptian Heart Journal, vol. 69, pp. 177-181, 2017. prehospital_and_hospital_delay_hossams.pdf
Youssef, G., Z. Saad, W. Ammar, and Yasser Sharaf, "Assessment of left ventricular regional wall motion abnormalities using regional time-volume curves obtained by real time three-dimensional echocardiography", The Egyptian heart journal, vol. 70, issue 3, pp. 189-194, 2018. 3d_assessment_of_swma.pdf
Youssef, G., N. T. Allam, W. Gaber, A. Afifi, and D. Hesham, "Increased arterial stiffness in rheumatoid arthritis and Its relation to disease activity: A cross sectional study", Egyptian Heart Journal, vol. 70, issue 1, pp. 35-40, 2018. arterial_stiffness_in_rheumatoid_arthritis.pdf
Youssef, G., S. Nagy, A. El-gengehe, A. Abdelaal, and M. A. Hamid, "Masked uncontrolled hypertension: Prevalence and predictors", Egyptian Heart Journal, vol. 70, issue 4, pp. 369-373, 2018. much.pdf
Youssef, G., "Mitral stenosis in pregnant patients", E-journal of Cardiology Practice, vol. 16, N° 18, 2018.
Youssef, G., S. Nagy, ahmed talaat, and M. A. Hamid, "P3804 Once vs twice daily anti-hypertensive medication: which is better in nighttime blood pressure control?", European Heart Journal, Suppl, vol. 39, issue 1, pp. 566, 2018.
Youssf, G., S. Nagy, ahmed talaat, and M. A. Hamid, "P6580 Pattern of 24 hours ambulatory blood pressure readings in hypertensive patients with controlled office blood pressure measurements", European Heart Journal, vol. 39, issue 1, 2018.
van Hagen, I. M., S. A. Thorne, N. Taha, G. Youssef, A. Elnagar, H. Gabriel, Y. ElRakshy, B. Iung, M. R. Johnson, R. Hall, et al., "Pregnancy Outcomes in Women With Rheumatic Mitral Valve Disease Results From the Registry of Pregnancy and Cardiac Disease", Circulation, vol. 137, pp. 806-816, 2018. Pregnancy outcome in mitral stenosis.pdf
ELFaramawy, A., W. ElAroussy, G. Youssef, D. El Remisy, H. El Deeb, A. Abdelaal, and M. Ibrahim, " PREVALENCE OF CARDIOVASCULAR RISK FACTORS AMONG HYPERTENSIVE EGYPTIANS, DATA FROM THE EGYPTIAN SPECIALIZED HYPERTENSION CLINICS", Journal of Hypertension, vol. 37, pp. e168, 2019. prevalence_of_cardiovascular_risk_factors_among.475.pdf
Rizk, H. H., A. A. Elamragy, G. S. Youssef, M. S. Meshaal, A. Samir, A. E. sharkawy, K. Said, H. H. Kassem, M. G. ElAnany, A. A. El-Kholy, et al., "Clinical features and outcomes of infective endocarditis in Egypt: an 11-year experience at a tertiary care facility.", The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology, vol. 71, issue 1, pp. 17, 2019. Abstract

BACKGROUND: Few data are available on the characteristics of infective endocarditis (IE) cases in Egypt. The aim of this work is to describe the characteristics and outcomes of IE patients and evaluate the temporal changes in IE diagnostic and therapeutic aspects over 11 years.

RESULTS: The IE registry included 398 patients referred to the Endocarditis Unit of a tertiary care facility with the diagnosis of possible or definite IE. Patients were recruited over two periods; period 1 (n = 237, 59.5%) from February 2005 to December 2011 and period 2 (n = 161, 40.5%) from January 2012 to September 2016. An electronic database was constructed to include information on patients' clinical and microbiological characteristics as well as complications and mortality. The median age was 30 years and rheumatic valvular heart disease was the commonest underlying cardiac disease (34.7%). Healthcare-associated IE affected 185 patients (46.5%) and 275 patients (69.1%) had negative blood cultures. The most common complications were heart failure (n = 148, 37.2%), peripheral embolization (n = 133, 33.4%), and severe sepsis (n = 100, 25.1%). In-hospital mortality occurred in 108 patients (27.1%). Period 2 was characterized by a higher prevalence of injection drug use-associated IE (15.5% vs. 7.2%, p = 0.008), a higher staphylococcal IE (50.0% vs. 35.7%, p = 0.038), lower complications (31.1% vs. 45.1%, p = 0.005), and a lower in-hospital mortality (19.9% vs. 32.1%, p = 0.007).

CONCLUSION: This Egyptian registry showed high rates of culture-negative IE, complications, and in-hospital mortality in a largely young population of patients. Improvements were noted in the rates of complications and mortality in the second half of the reporting period.

Youssef, G., "Hypertension in pregnancy", E-Journal of Cardiology Practice, vol. 17, issue N° 22, 2019.
Youssef, G. S., "Management of atrial fibrillation during pregnancy", E-journal of Cardiology Practice, vol. 17, issue N° 15, 2019.
Youssef, G., D. Mekkawy, N. E. Fayoumy, A. Abbass, and M. Allam, "P1817 Assessment of carotid stiffness indices in patients with ischemic stroke", European Heart Journal, vol. 40, 2019. abstract_esc.docx
Youssef, G., M. Mashaal, D. El Remaisy, K. Sorour, and H. Rizk, "Pericardial Effusion In Prosthetic and Native Valve Infective Endocarditis", Indian Heart Journal, vol. 71, pp. 80-84, 2019. pe_in_ie_paper.pdf
Youssef, G., "Aortic valve diseases in pregnancy", E-Journal of Cardiology Practice, vol. Vol. 18, issue N° 19, 2020. avd_during_pregnancy.pdf
Youssef, G., S. Nagy, A. El-gengehe, M. A. Hamid, and A. Abdelaal, "Once versus twice daily antihypertensive medications for the control of nocturnal blood pressure: a comparative study.", The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology, vol. 72, issue 1, pp. 9, 2020. Abstract

BACKGROUND: Blood pressure (BP) shows short-term variability within the 24 h, which can only be assessed with 24-h ambulatory blood pressure monitoring (ABPM). It is of utmost importance to control BP throughout the night to reduce incidence of hypertension complications. The purpose of this study is to evaluate the effect of timing and frequency of antihypertensive medications on the average nighttime and 24-h blood pressure control.

RESULTS: The study enrolled 199 hypertensive patients with controlled office blood pressure; 135 (67.8%) patients were on once daily antihypertensive medication (group 1) while 64 (32.2%) patients were on twice daily doses (group 2). The mean office SBP was 128.7 ± 7.8 mmHg in group 1 vs 129.6 ± 6.6 mmHg in group 2, (p = 0.421). ABPM readings for both groups were as follows: mean daytime SBP was 125.4 ± 11.6 mmHg vs 130.1 ± 12.9, p = 0.011; mean nighttime SBP was 117.0 ± 12.4 mmHg vs 123.1 ± 13.9 mmHg, p = 0.002, and mean 24-h SBP was 122.7 ± 10.6 mmHg vs 127.5 ± 12.0, p = 0.005. The prevalence of non-dipping was 68.9% in group 1 vs 70.3% in group 2 patients, p = 0.8 (the mean dipping ratio was 0.93 ± 0.08 in group 1 vs 0.95 ± 0.07 in group 2, p = 0.198). The prevalence of masked hypertension was higher in group 2 (28.1% vs 43.8%, p = 0.029).

CONCLUSION: Taking an extra antihypertensive pill at night did not show a decrease in the nighttime or the average 24H blood pressure in hypertensive patients with controlled office BP. On the contrary, patients who used twice daily antihypertensive medications seem to have higher nighttime and 24-h SBP, although the dipping ratio was comparable in both groups.

Sliwa, K., L. Baris, C. Sinning, E. Zengin-Sahm, L. Gumbiene, I. F. Yaseen, G. Youssef, M. Johnson, H. Al-Farhan, Malgorzata Lelonek, et al., "Pregnant Women With Uncorrected Congenital Heart Disease: Heart Failure and Mortality.", JACC. Heart failure, vol. 8, issue 2, pp. 100-110, 2020. Abstract

OBJECTIVES: The purpose of this work was to study maternal and fetal outcomes of women with uncorrected congenital heart disease (CHD).

BACKGROUND: Globally, CHD is an important cause of maternal morbidity and mortality in women reaching reproductive stage. Data are lacking from larger cohorts of women with uncorrected CHD.

METHODS: The 10-year data from the European Society of Cardiology EORP ROPAC (EURObservational Research Programme Registry of Pregnancy and Cardiac disease) registry of women with uncorrected CHD were analyzed.

RESULTS: Of 5,739 pregnancies in 53 countries, 3,295 women had CHD, 1,059 of which were uncorrected cases. Of these, 41.4% were from emerging countries. There were marked differences between the cardiac defects in uncorrected cases versus those in corrected CHD cases with primary shunt lesions (44.7% vs. 32.4%, respectively), valvular abnormalities (33.5% vs. 12.6%, respectively), and Tetralogy of Fallot and pulmonary atresia (0.8% vs. 20.3%, respectively; p < 0.001). In patients with uncorrected CHD, 6.8% were in modified World Health Organization risk class IV, approximately 10% had pulmonary hypertension (PH), and 3% were cyanotic prior to pregnancy. Maternal mortality and heart failure (HF) in the women with uncorrected CHD were 0.7% and 8.7%, respectively. Eisenmenger syndrome was associated with a very high risk of cardiac events (65.5%), maternal mortality (10.3%), and HF (48.3%). Coming from an emerging country was associated with higher pre-pregnancy signs of HF, PH, and cyanosis (p < 0.001) and worse maternal and fetal outcomes, with a 3-fold higher rate of hospital admissions for cardiac events and intrauterine growth retardation (p < 0.001).

CONCLUSIONS: Marked differences between cardiac conditions in pregnant women with uncorrected CHD and those in corrected CHD were found, with a markedly worse outcome, particularly in women with Eisenmenger syndrome and from emerging countries.

ELFaramawy, A., G. Youssef, W. ElAroussy, D. El Remisy, H. El Deeb, A. Abdelaal, and M. M. Ibrahim, "Registry of the Egyptian specialized hypertension clinics: patient risk profiles and geographical differences.", Journal of human hypertension, vol. 34, issue 7, pp. 520-527, 2020. Abstract

Data regarding the prevalence and characteristics of cardiovascular (CV) risk factors among Egyptian hypertensive patients are limited. Nationwide Specialized Hypertension Clinics (SHCs) were initiated for screening, investigating, and treating hypertensive patients. This study aimed to determine the clinical characteristics and the CV risk profile of hypertensive Egyptians attending SHCs. Data from 4701 hypertensive patients were collected from the SHCs of nine university hospitals representing the different geographical regions of Egypt. Data collection started in October 2014 and ended in September 2017. Data included blood pressure (BP) measurements, clinical data, socio-demographic characteristics, anthropometric measurements, and cardiovascular risk profiles. The patients' mean age was 51.8 ± 11.5 years, 58.7% were older than 50 years, and 58.5% were females. The mean office systolic and diastolic BP values were 145.2 ± 22.4 and 88.7 ± 12.9 mmHg, respectively. Regarding CV risk factors, 58.6% were obese, 23.4% were smokers, and 25.1% had diabetes mellitus. Obesity was more prevalent in females than males (65.7% vs. 53.0%, p < 0.001, respectively), while dyslipidaemia and smoking were significantly more common in male patients. The highest levels of BP and the highest global risk were observed in the inhabitants of the Delta region, despite their younger age. In conclusion, this study revealed a high prevalence of modifiable CV risk factors among a cohort of Egyptian hypertensive patients attending SHCs. The pattern of the risk factors across the different geographic regions may be attributed to rapid urbanization. Governmental and community-based approaches are needed for better control of hypertension and its associated CV risk factors.