Ghada Radwan

Citation:

Noaman, M. K., N. A. Labib, G. N. Radwan, O. M. Mansour, M. M. Moneer, and I. A. Elattar, Hepatic Cancer, , 2011.

Abstract:

Background: Hepatocellular carcinoma (HCC) is a major contributor to cancer incidence and mortality.
HCC is a highly fatal disease and is the third leading cause of death from malignancy worldwide. The aim of the study
was to determine long-term survival and prognostic factors predictive of the overall survival of HCC patients at the
National Cancer Institute (NCI), Cairo University. Patients and methods: A prospective study was conducted on a
cohort of 212 HCC patients attending to the medical oncology clinic at the National Cancer Institute (NCI) during the
period from July,1, 2007 till August, 31,2008 and they were followed up by phone till November 7th, 2010. Results:
The study revealed that 1-year, 2-year, 3-year survival rates of HCC patients were 26.9%, 9.4%, 5.0% respectively,
and median overall survival was 6.3 months (95% CI 5.4-7.2). Multivariate analysis revealed that independent
predictors of poor survival were pretreatment presence of extrahepatic metastasis and ascites, and not receiving
radiofrequency ablation (RFA) as a treatment modality. Conclusion: The study concludes that most HCC patients at
NCI presented at a late stage and their survival was poor. Preserved liver function, non-metastatic presentation of the
hepatic tumor and receiving RFA as a treatment modality are associated with good survival of HCC patients.
[Maissa K Noaman, Nargis A Labib, Ghada N Radwan, Othman M Mansour, Manar M Moneer and Inas A Elattar
Prognostic Factors for Survival of Patients with Hepatocellular Carcinoma in National Cancer Institute, Cairo
University. Journal of American Science 2011; 7(9):831-839]. (ISSN: 1545-1003).