Gehan shahin

Citation:

Shahin, R. M. H., N. H. M. Shaheen, G. H. Shahin, and R. M. E. Refai, "Association analysis of systemic lupus erythematosus and −1514 polymorphism of TBX21 gene in the Egyptian population", Comp Clin Pathol, vol. 21, issue 5, 2012.

Abstract:

The T-box21 (TBX21) gene encodes the transcription
factor T-bet (T-box expressed in T cells), which influences
naïve T lymphocyte development and has been implicated in
the pathogenesis of many diseases. We aimed to assess the
implication of the TBX21 gene promoter T-1514C polymorphism
in susceptibility to systemic lupus erythematosus (SLE)
in a cohort of Egyptian population and to study the association
between the genetic polymorphism of that gene and the clinical
and laboratory data of these patients. The study included 50
SLE patients. Sixty age, sex, and ethnically matched volunteers
were included in the current study as a control group. The
genotyping of T-1514C single nucleotide polymorphism was
performed by using a polymerase chain reaction–restriction
fragment length polymorphism assay. There was no statistically
significant difference in the distribution of the genotypes between
SLE patients and the control group in our study. No
association was detected between TBX21 genotypes and the
clinical features and laboratory data of the patients apart from
an association with the hematologic complications (anemia,
leucopenia, thrombocytopenia, or pancytopenia) with increased
frequency of hematological complications in the group carrying
the wild genotype (TT) (p00.016).