Fadi M. Awadallah

1) Post doctoral publications:

1- Fadi M. Awadallah, Franziska Mϋller, Jochen Lehmann, Ashraf H. Abadi

 “Synthesis of novel lactam derivatives and their evaluation as ligands for the dopamine receptors, leading to a D4-selective ligand.”

Bioorg. Med. Chem. 2007, 15, 5811-5818.

2- Fadi M. Awadallah “Synthesis, Pharmacophore modeling, and Biological Evaluation of Novel 5H-thiazolo[3,2-a]pyrimidin-5-one Derivatives as 5-HT2A Receptor Antagonists”

Sci. Pharm. 2008, 76, 415-438.

3- Safinaz E. Abbas, Fadi M.  Awadallah,   Nashwa A. Ibrahim and Ahmed M.  Gouda “Novel substituted and fused pyrrolizine derivatives: synthesis, anti-inflammatory and ulcerogenecity studies” Eur. J. Med. Chem. 45 (2010) 482-491.

4- Nehad A. El-Sayed, Fadi M. Awadallah, Nashwa A. Ibrahim, Mohammed T. El-Saadi, “Synthesis, anti-inflammatory and ulcerogenicity studies of some substituted pyrimido[1,6-a]azepine derivatives “ Eur. J.  Med. Chem., 45 (2010) 3147-3154.

5- Kamilia M. Amin, Hanan, H. Georgy, Fadi M. Awadallah, “EGRF tyrosine kinase targeted compounds: Synthesis, Docking study and In-vitro antitumor activity of some new quinazoline and benzo[d]isothiazole derivatives”  Med. Chem. Res. 20 (2010) 1042-1053.

6- Safinaz E. Abbas, Fadi M. Awadallah,   Nashwa A. Ibrahim, Ahmed M. Gouda and Bassem A. Shehata, “Design, Synthesis and Preliminary Evaluation of Some Novel [1,4]Diazepino [5,6-b]pyrrolizine and 6-(2-Oxopyrrolidino)-1H-pyrrolizine Derivatives as Anticonvulsant Agents.” Med. Chem. Res. 20 (2011) 1015-1023.

7- Nehad A. El-Sayed, Fadi M. Awadallah, Nashwa A. Ibrahim, Mohammed T. El-Saadi. "Potential anti-inflammatory activity and ulcerogenicity study of some novel pyrimido[4',5':4,5]pyrimido[1,6-a]azepine derivatives" Med. Chem. Res. 21 (2012) 395–405.

8- Kamilia M. Amin, Fadi M. Awadalla, Amal A.M. Eissa, Sahar M. Abou-Seri, Ghaneya S. Hassan. "Design, synthesis and vasorelaxant evaluation of novel coumarin–pyrimidine hybrids" Bioorg. Med. Chem. 19 (2011) 6087-6097.

9- Fadi M. Awadallah, Wafaa I. El-Eraky, Dalia O. Saleh. "Synthesis, vasorelaxant activity, and molecular modeling study of some new phthalazine derivatives" Eur. J. Med. Chem. 52 (2012) 14-21.

10- Safinaz E. Abbas, Fadi M. Awadallah, Nashwa A. Ibrahim, Eman G. Said, Gihan M. Kamel. "New quinazolinone-pyrimidine hybrids: Synthesis, anti-inflammatory,

and ulcerogenicity studies" Eur. J. Med. Chem. 53 (2012) 141-149.

11-  Kamilia M. Amin, Amal A.M. Eissa, Sahar M. Abou-Seri, Fadi M. Awadallah, Ghaneya S. Hassan. "Synthesis and biological evaluation of novel coumarin-pyrazoline hybrids endowed with phenylsulfonyl moiety as antitumor agents" Eur. J. Med. Chem. 60 (2013) 187-198.

12- Safinaz El-Sayed Abbas, Fadi Mohsen Awadallah, Nashwa Ahmed Ibrahim,Eman Gaber Said,and Gihan Kamel. “Design and Synthesis of Some 3-Substituted-2-[(2,4-dichlorophenoxy)methyl]quinazolin-4(3H)-one Derivatives as Potential Anticonvulsant Agents” Chem. Pharm. Bull. 61 (2013) 679–687.

13- Fadi M. Awadallah, Gary A. Piazza, Bernard D. Gary, Adam B. Keeton, Joshua C. Canzoneri. “Synthesis of some dihydropyrimidine-based compounds bearing pyrazoline moiety and evaluation of their antiproliferative activity” Eur. J. Med. Chem. 70 (2013) 273-279.

14- Safinaz E.-S. Abbas, Enayat I. Aly, Fadi M. Awadallah and Walaa R. Mahmoud.

"4-Substituted-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine Derivatives: Design, Synthesis, Antitumor and EGFR Tyrosine Kinase Inhibitory Activity" Chem. Biol. Drug Des, 85 (2015) 608-622.

15-  Kamilia M. Amin, Sahar M. Abou-Seri, Fadi M. Awadallah, Amal A.M. Eissa, Ghaneya S. Hassan, Mohamed M. Abdulla "Synthesis and anticancer activity of some 8-substituted-7-methoxy-2H-chromen-2-one derivatives toward hepatocellular carcinoma HepG2 cells"  Eur. J. Med. Chem. 90 (2015) 221-231.

16- Fadi M. Awadallah, Sahar M. Abou-Seri, Mohamed M. Abdulla, Hanan H. Georgey. "Design and synthesis of potent 1,2,4-trisubstituted imidazolinone derivatives with dual p38αMAPK and ERK1/2 inhibitory activity"  Eur. J. Med. Chem. 94 (2015) 397-404.

17- Fadi M. Awadallah, Tamer A. El-Waei, Mona M. Hanna, Safinaz E. Abbas, Mariangela Ceruso, Beyza Ecem Oz, Ozen Ozensoy Guler, Claudiu T. Supuran. "Synthesis, carbonic anhydrase inhibition and cytotoxic activity of novel chromone-based sulfonamide derivatives"  Eur. J. Med. Chem. 96 (2015) 425-435.

18- Ghaneya S. Hassan, Fadi M. Awdallah, Mohamed T. El-Saadi, Ahmed O. Elgendi and Loah R. Hemeda. "Synthesis of some benzothiazole derivatives evaluated as antimicrobials and antibiofilms" J. Chem. Pharm. Res. 7 (2015) 1125-1143.

19- Kamilia M. Amin, Flora F. Barsoum, Fadi M. Awadallah, Nehal E. Mohamed, “Identification of new potent phthalazine derivatives with VEGFR-2

and EGFR kinase inhibitory activity” Eur. J. Med. Chem. 123 (2016) 191-201.

20- Riham I. Ahmed, Essam Eldin A. Osman, Fadi M. Awadallah & Samir M. El-

Moghazy, “Design, synthesis and molecular docking of novel diarylcyclohexenone and diarylindazole derivatives as tubulin polymerization inhibitors” J. Enz. Inh. Med. Chem., 32 (2017) 176-188.

21- Heba A. Ibrahim, Fadi M. Awadallah, Hanan M. Refaat, Kamilia M. Amin, “Molecular docking simulation, synthesis and 3D pharmacophore studies of novel 2-substituted-5-nitro-benzimidazole derivatives as anticancer agents targeting VEGFR-2 and c-Met” Bioorg. Chem. 77 (2018) 457-470.

22- Heba A. Ibrahim, Fadi M. Awadallah, Hanan M. Refaat, Kamilia M. Amin, “Design, synthesis and molecular modeling study for some new 2-substituted benzimidazoles as dual inhibitors for VEGFR-2 and c-Met” Future Med. Chem. 10 (2018) 493-509.

23- Fadi M. Awadallah, Silvia Bua, Walaa R. Mahmoud, Hossam H. Nada, Alessio

Nocentini & Claudiu T. Supuran, “Inhibition studies on a panel of human carbonic anhydrases with N1-substituted secondary sulfonamides incorporating thiazolinone or imidazolone-indole tails”, J. Enz. Inh. Med. Chem., 33 (2018) 629-638.

2) Patents:

 Antiproliferative active fluoro-substituted spiro-alkaloids, number 1975/2013; 25/12/2013.

3) Projects:

- Co-worker in a project entitled:”Design, Synthesis and Evaluation of Cardiovascular Activity of Novel Substituted Coumarin Derivatives”, funded by Cairo university (1 Jan 2009- 31 Dec 2010).

4) Peer reviewer:

-         Reviewer for some international journals such as: European journal of Medicinal chemistry (Eur. J. Med. Chem.) and Letters in drug design and discovery (Lett. Drug Des. Discov.), Medicinal Chemistry Research (Med. Chem. Res.) Archiv der Pharmazie (Arch. Pharm), Molecules, International journal of medicinal chemistry (Intl. J. Med. Chem.), British Journal of Pharmacology (Br. J. Pharmacol.), Bulletin of Faculty of Pharmacy Cairo University (Bull. Fac. Pharm. Cairo Univ.), Journal of advanced research (J. Adv. Res.), Molecular Biodiversity (Mol. Biodiv.), Organic Communications (Org. Comm.), Medicinal Chemistry Communications(MedChemComm).

-         Reviewer for research proposals (Newton-Mosharafa, STDF,..)

5) Conferences:

1- The 1^st Scientific Conference of Faculty of Pharmacy Cairo University, under the theme of “Pharmacy role in Community Health Promotion”, March 29^th 2008.

Dissertation: “Synthesis, Pharmacophore modeling, and Biological Evaluation of Novel 5H-thiazolo[3,2-a]pyrimidin-5-one Derivatives as 5-HT_2A Receptor Antagonists”

2- The 2nd Conference of Egyptian Humboldtians, under the theme of "Humboldtians in Natural Sciences and Engeneering", German University in Cairo, September 8-9, 2007.

3- The 1st International Conference of the Quality Assurance and Accreditation Center Cairo University, under the theme of "Quality and Accreditation, The Present and The Prospective", April 15 2008.

4- The 2^nd Scientific Conference of Faculty of Pharmacy, Cairo University, April 26^th 2010.

Dissertation:”Synthesis, anti-inflammatory and ulcerogenicity studies of some substituted pyrimido[1,6-a] azepine derivatives”.

5- The 13^th  Assembly of Arab Universities (AARU) Conference of the Pan Arab colleges of Pharmacy, College of Pharmacy and Pharmaceutical Manufacture, Misr University for Science and Technology 25-27 May 2010.

Dissertation: “EGRF tyrosine kinase targeted compounds: Synthesis, Docking study and In-vitro antitumor activity of some new quinazoline and benzo[d]isothiazole derivatives”.

6- The 3^rd Scientific Conference of Faculty of Pharmacy, Cairo University, “Good Pharmacy Practice” April 25&26^th 2012.

Dissertation:” Design, synthesis and anticonvulsant activity of some 2,3-disubstituted quinazolinone and 3,4-annelated quinazoline derivatives”.

7- Future University International Conference on Pharmaceutical Technologies

February 6-9, 2012.

Dissertation:" Synthesis and molecular modeling study of some new phthalazine derivatives of potential vasorelaxant activity"; and " New quinazolinone-pyrimidine hybrids: synthesis, anti-inflammatory and ulcerogenecity studies".

8- The 4^th Scientific Conference of Faculty of Pharmacy, Cairo University, "Pharmacy Education and Community Expectations" April 24^th and 25^th, 2013.

Dissertation: ” Synthesis of some 8-substituted-7-methoxy-2H-chromen-2-one derivatives and their in vitro screening for antineoplastic activity”. 

9- The 5^th International Scientific Conference of Faculty of Pharmacy Cairo University, "Pharmacy at the cutting-edge: Facing future challenges" April 23^rd and 24^th, 2014.

Dissertation: "Synthesis of some dihydropyrimidine-based compounds bearing pyrazoline moiety and evaluation of their antiproliferative activity".

And,

Oral presentation: "Molecular modeling in Pharmaceutical R&D:Considerations for the design of Pharmaceuticals.

10- FUE International Conference of Pharmaceutical Sciences, February 9-11, 2015.

Dissertation: "Design and synthesis of potent 1,2,4-trisubstituted imidazolinone derivatives with dual p38αMAPK and ERK1/2 inhibitory activity".

11- 16^th Tetrahedron Symposium, "Challenges in Bioorganic and Organic Chemistry" June 16-19, 2015, Berlin, Germany.

Dissertation: "Design and synthesis of potent 1,2,4-trisubstituted imidazolinone derivatives with dual p38αMAPK and ERK1/2 inhibitory activity". 

12- 18^th Tetrahedron Symposium, “New developments in Organic Chemistry” Jume 27-30, 2017, Budapest, Hungary.

Dissertation: “Design, Synthesis, and Molecular Docking of Novel Diarylcyclohexenone and Diarylindazole Derivatives as Tubulin Polymerization Inhibitors”