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Mabrouk, Mahasen, Gamal Esmat, Ayman Yosry, Magdy El-Serafy, Wahid Doss, Naglaa Zayed, Medhat El-Sahhar, Sally Awny, and Ashraf Omar. "Health-related quality of life in Egyptian patients after liver transplantation." ANNALS OF HEPATOLOGY 11 (2012): 882-890. Abstract
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Mabrouk, Mahasen, Maissa El-Raziky, Naglaa Zayed, Rabab Salama, Wafaa El-Akel, Tahany Awad, Mohammad El Beshlawy, and Gamal Esmat. "Clinical, biochemical and pathological profiles of 5464 Egyptian chronic hepatitis C-infected patients." Hepato-gastroenterology 60, no. 127 (2013): 1731-5. Abstract

BACKGROUND/AIMS: In Egypt, hepatitis C virus (HC is highly endemic with at least 91% are genotype-4. However, HCV-specific burden data for Egypt are scarce. The study aims to identify clinical, biochemical and pathological features of chronic HCV population in Egypt.

METHODOLOGY: We analyzed retrospective data of 5,464 HCV-antibody and PCR positive patients attending pre-treatment assessment at one of the National Treatment Centers, Cairo, Egypt.

RESULTS: Chronic HCV patients were males (81.4%) in their productive age, mean body mass index (BMI): 28 kg/m2. Laboratory profile demonstrated mean platelet count 214 x 10(3)/µ L with only 14% having thrombocytopenia, amino-transferases were mildly elevated: mean AST, ALT were 56 and 63 respectively,low viraemia: 50% had viral load <100 (x 10(3)) IU/mL,and median AFP level 3.3 ng/mL. Liver biopsy revealed ≤A2 in 92% of patients; 80% had ≤F2 and 7.3 % had F4 according to the METAVIR score. Meta regression demonstrated that advanced stages of fibrosis were significantly correlated with platelet count, AST/ALT ratio, AFP levels and BMI (p <0.001). However there was no correlation with viral load.

CONCLUSIONS: To our knowledge, this is the first study on nationwide scale that provided the demographic, biochemical,and histological characteristics for this number of chronic HCV patients presumably genotype-4.

Maher, Mohsen M., Sayed M. Shalaby, Gamal Esmat, Mohamed Abd El Adl Al-Sawey, Manal Zaghloul Maharan, Tarek M. Yosef, Wesam A. Ibrahim, Naglaa Zayed, Nesrine A. Mohamed, and Sarah Abdel Kader El-Nakeep. "Light Chain Antigenic Determinants (kappa and gamma) Influence on the Treatment Outcome of Chronic Hepatitis C Infection in Egypt." LIFE SCIENCE JOURNAL-ACTA ZHENGZHOU UNIVERSITY OVERSEAS EDITION 9 (2012): 2329-2333. Abstract
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Mahmoud El-Bendary, Mustafa Neamatallah, Hatem Elalfy, Hend Mousa Tarek Besheer, Emily Kamel, Abdel-Hady El-Gilany Abdel-Hamid Eladl, Maged El-Setouhy, and Gamal Esmat Ahmed El-Waseef. "HLA Class II-DRB1 Alleles with Hepatitis C Virus Infection Outcome in Egypt: A Multicentre Family-based Study ." Annals of Hepatology 18, no. 1 (2019): 68-77 .1-s2.0-s1665268119303084-main.pdf_-_hla_class_ii-drb1_alleles_with_hcv_infection_outcome_in_egypt.pdf
Males, S., R. R. Gad, G. Esmat, M. Said, C. Rekacewicz, K. Zalata, M. Abdel-Hamid, P. Bedossa, S. Pol, M. K. Mohamed et al. "Serum alpha-fetoprotein (AFP) level predicts treatment outcome in chronic hepatitis C (ANRS 1211)." JOURNAL OF CLINICAL VIROLOGY 36 (2006): S133. Abstract
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Males, Sylvia, Rita Raafat Gad, Gamal Esmat, Hasan Abobakr, Mohamed Anwar, Claire Rekacewicz, Mostafo El Hoseiny, Khaled Zalata, Mohamed Abdel-Hamid, Pierre Bedossa et al. "Serum alpha-foetoprotein level predicts treatment outcome in chronic hepatitis C." ANTIVIRAL THERAPY 12 (2007): 797-803. Abstract
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Males, S., R. Raafat, G. Esmat, M. Said, M. Anwar, C. Rekacewicz, K. Zalata, M. Abdel-Hamid, P. Bedossa, S. Pol et al. "Serum alpha-fetoprotein (AFP) level predicts treatment outcome in chronic hepatitis C." LIVER INTERNATIONAL 26 (2006): 82. Abstract
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Mekky, Radwa Yehia, Nada Magdy El-Ekiaby, Mohammed Tarif Hamza, Noha Mousaad Elemam, Mohammed El-Sayed, Gamal Esmat, and Ahmed Ihab Abdelaziz. "Mir-194 is a hepatocyte gate keeper hindering HCV entry through targeting CD81 receptor." The Journal of infection (2014). Abstract

OBJECTIVE: The tetraspanin CD81 is one of the main receptors involved in hepatitis C virus entry. Herein, we aimed to explore the role of microRNAs in regulating CD81 receptor expression and function.

PATIENTS AND METHODS: Bioinformatics analysis was carried out to select potential mircroRNAs that binds CD81 3'untranslated region. Liver biopsies taken from 28 HCV genotype- 4 patients and 10 healthy donors were screened. Naïve, JFH1 and ED43/JFH1- infected- Huh7 cells were transfected with mimics and inhibitors followed by analyzing CD81 protein and mRNA expression. This was done using flow cytometry and Q-RT PCR, respectively. HCV entry into Huh7 cells was investigated post-transfection. Binding confirmation was done using luciferase reporter vector harboring wild/mutant target sites of microRNA. The impact of Epigallocatechin-gallate on modulating microRNA/CD81 expression was assessed.

RESULTS: Bioinformatics revealed that CD81 is a potential down-stream target for miR-194. A significant inverse correlation was found between miR-194 and CD81 expression in liver biopsies of HCV patients. Forcing the expression of miR-194 showed a down-regulation of CD81 protein, mRNA expression and significantly abrogated the HCV infectivity of Huh7 cells. Stimulation with EGCG enhanced mir-194 expression and down-regulated CD81 expression.

CONCLUSION: This study showed that mir-194 hinders HCV entry through targeting CD81 receptors.

Mekky, Radwa Y., Nabila Hamdi, Wafaa El-Akel, Gamal Esmat, and Ahmed I. Abdelaziz. "Estrogen-related MxA transcriptional variation in hepatitis C virus-infected patients." TRANSLATIONAL RESEARCH 159 (2012): 190-196. Abstract
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Metwally, M., G. Esmat, K. Zalata, M. K. Mohamed, H. Khattab, M. El Batanouni, M. El Daly, M. Anwar, A. Hassan, S. Ismail et al. "Histopathological characterization of genotype 4 chronic hepatitis C." LIVER INTERNATIONAL 26 (2006): 78. Abstract
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Metwally, M. A., A. Youssef, Abdel K. Qawi, I. Rageh, Abdel M. Hamid, A. Shaheen, and G. Esmat. "Prevalence and risk factors of hepatitis C among pregnant females in Egypt." JOURNAL OF CLINICAL VIROLOGY 36 (2006): S204. Abstract
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Metwally, M., A. Youssif, K. Qawi, I. Rageh, Abdel M. Hamid, A. Shaheen, and G. Esmat. "Prevalence and risk factors of hepatitis C among pregnant females in Egypt." LIVER INTERNATIONAL 26 (2006): 77. Abstract
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Mohamed, M. K., I. Bakr, M. El-Houssinie, N. Arafa, A. Hassan, S. Ismail, M. Anwar, M. Attala, C. Rekacewicz, K. Zalata et al. "Hepatitis C-related morbidity in a rural community of Egypt." LIVER INTERNATIONAL 26 (2006): 74-75. Abstract
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Mohamed, M. K., I. Bakr, M. El-Houssinie, N. Arafa, A. Hassan, S. Ismail, M. Anwar, M. Attala, C. Rekacewicz, K. Zalata et al. "HCV-related morbidity in a rural community of Egypt." JOURNAL OF CLINICAL VIROLOGY 36 (2006): S131. Abstract
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Mohamed, Mostafa K., Iman Bakr, Mostafa El-Hoseiny, Naglaa Arafa, Abubakr Hassan, Soheir Ismail, Mohamed Anwar, Mohamed Attala, Claire Rekacewicz, Khaled Zalata et al. "HCV-related morbidity in a rural community of Egypt." JOURNAL OF MEDICAL VIROLOGY 78 (2006): 1185-1189. Abstract
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Mohamed, Mostafa K., Sylvie Deuffic-Burban, Fabrice Carrat, Gamal Esmat, Alaa Ismail, Hesham El Makhzangy, Bernard Larouze, Ibrahim Abdelbar, Abdel-Rahman El-Zayadi, and Alain-Jacques Valleron. "Burden of hepatitis C-related HCC mortality in Egypt due to pre-2000 infections." JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 21 (2006): A184. Abstract
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Mohamed Gamil, Mohamed Alboraie, Noha Asem Mohammad El-Sayed, Aisha Elsharkawy, Bahaa Abbas Mai Mehrez Tamer Elbaz, Mohammad Mohey, and Gamal Esmat. "Novel scores combining AFP with non-invasive markers for prediction of liver fibrosis in chronic hepatitis C patients." Journal of Medical Virology 90 (2018): 1080-1086.gamil_et_al-2018-journal_of_medical_virology1.pdf
Mohammed, Reem Hamdy Abdellatif, Hesham Ibrahim ElMakhzangy, Amira Gamal, Fatma Mekky, Mohammed El Kassas, Nabil Mohammed, Mohammed Abdelhamid, and Gamal Esmat. "Prevalence of rheumatologic manifestations of chronic hepatitis C virus infection among Egyptians." CLINICAL RHEUMATOLOGY 29 (2010): 1373-1380. Abstract
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Mohammed, Reem Abdellatif H., Hesham I. Elmakhzangy, Gamal Esmat, Amira Gamal, Fatma Mekky, Nabil M. Ibrahim, and Mohammed A. Elhamid. "PREVALENCE OF EXTRAHEPATIC RHEUMATOLOGICAL MANIFESTATIONS IN EGYPTIAN PATIENTS WITH CHRONIC HEPATITIS C VIRUS INFECTION." RHEUMATOLOGY 49 (2010): I61-I62. Abstract
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Mohsen, A., E. M. Ibrahim, S. Al Aidi, S. El Mango, A. Bernier, M. El Daly, M. El Gafaary, Abdel M. Hamid, G. Esmat, M. Gadallah et al. "COMMUNITY TRANSMISSION OF HEPATITIS C VIRUS AMONG EGYPTIANS: ANALYSIS OF A 10 YEARS CASE-CONTROL STUDY." JOURNAL OF HEPATOLOGY 58 (2013): S398. Abstract
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Mostafa, Aya, Mostafa K. Mohamed, Mohamed Saeed, Abubakr Hasan, Arnaud Fontanet, Ian Godsland, Emma Coady, Gamal Esmat, Mostafa El-Hoseiny, Mohamed Abdul-Hamid et al. "Hepatitis C infection and clearance: impact on atherosclerosis and cardiometabolic risk factors." GUT 59 (2010): 1135-1140. Abstract
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