Publications

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A
Abbas, Emad, Olfat Shaker, Ghada Abd El Aziz, Huda Ramadan, and Gamal Esmat. "Epidermal growth factor gene polymorphism 61A/G in patients with chronic liver disease for early detection of hepatocellular carcinoma: a pilot study." EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 24 (2012): 458-463. Abstract
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Abdel-Hamid, Mohamed, Mai El-Daly, Vilma Molnegren, Sherif El-Kafrawy, Sohair Abdel-Latif, Gamal Esmat, Thomas G. Strickland, Christopher Loffredo, Jan Albert, and Anders Widell. "Genetic diversity in hepatitis C virus in Egypt and possible association with hepatocellular carcinoma." JOURNAL OF GENERAL VIROLOGY 88 (2007): 1526-1531. Abstract
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Abdel-Rahman, Mahasen, Mohammad El-Sayed, Maissa El Raziky, Aisha Elsharkawy, Wafaa El-Akel, Hossam Ghoneim, Hany Khattab, and Gamal Esmat. "Coinfection with hepatitis C virus and schistosomiasis: Fibrosis and treatment response." WORLD JOURNAL OF GASTROENTEROLOGY 19 (2013): 2691-2696. Abstract
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Abdel-Rahman, Mahasen, Yasmin Saad, Maissa El-Raziky, Naglaa Zayed, Wafaa El-Akel, Mohamed Said, Mohamed El-Beshlawy, and Gamal Esmat. "Hepatitis C genotype 4 with normal transaminases: Correlation with fibrosis and response to treatment, a cohort Egyptian study of 4277 patients." CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY 37 (2013): 479-484. Abstract
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Abdel-Rahman N Zekri, Somaya El Deeb, Abeer Bahnassy A., Mona Abdellateif S. Abeer M Badr, Marwa Mohanad Gamal Esmat, Hosny Salama, and Assmaa Abd Elkader Ahmed Esam El-dien, Shimaa Rabah. "Role of relevant immune-modulators and cytokines in hepatocellular carcinoma and premalignant hepatic lesions ." World Journal of Gastroenterology 24, no. 11 (2018): 1228-1238 .wjg-24-1228.pdf
Abdel-Razek, Wael, Mohamed Hassany, Manal Hamdy El-Sayed, Magdy El-Serafy, Wahid Doss, Gamal Esmat, and Imam Waked. "Hepatitis C Virus in Egypt: Interim Report From the World's Largest National Program." Clinical liver disease 14, no. 6 (2019): 203-206.
Abdel-Wahab, MF, G. Esmat, Y. El-Boraey, I. Ramzy, E. Medhat, and GT Strickland. "The epidemiology of schistosomiasis in Egypt: Methods, training, and quality control of clinical and ultrasound examinations." AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 62 (2000): 17-20. Abstract
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Abdel-Wahab, MF, G. Esmat, E. Medhat, S. Narooz, I. Ramzy, Y. El-Boraey, and GT Strickland. "The epidemiology of schistosomiasis in Egypt: Menofia Governorate." AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 62 (2000): 28-34. Abstract
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Abdel-Wahab, MF, G. Esmat, I. Ramzy, S. Narooz, E. Medhat, M. Ibrahim, Y. El-Boraey, and GT Strickland. "The epidemiology of schistosomiasis in Egypt: Fayoum Governorate." AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 62 (2000): 55-64. Abstract
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Abdelaziz, AO, AY Hamad, G. Esmat, M. A-Serafy, W. Doss, A. Hosny, A. Ansary, and K. Tanaka. "Tacrolimus (FK 506) toxicity in the early postoperative period following living donor liver transplantation (LDLT) among Egyptian adults: Limited experiance." LIVER TRANSPLANTATION 11 (2005): C44. Abstract
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AbdelRaouf, T., H. El Makhzangy, G. Esmat, A. Yousry, A. Amer, A. Abouzeid, and M. Tawfik. "Prevalence of liver disease in Cairo over a 10-year period." LIVER INTERNATIONAL 26 (2006): 88. Abstract
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ABDELWAHAB, MF, G. Esmat, A. FARRAG, Y. ELBORAEY, and GT Strickland. "ULTRASONOGRAPHIC PREDICTION OF ESOPHAGEAL-VARICES IN SCHISTOSOMIASIS-MANSONI." AMERICAN JOURNAL OF GASTROENTEROLOGY 88 (1993): 560-563. Abstract
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ABDELWAHAB, MF, S. Zakaria, M. Kamel, MK ABDELKHALIQ, MA MABROUK, H. SALAMA, G. Esmat, DL THOMAS, and GT Strickland. "HIGH SEROPREVALENCE OF HEPATITIS-C INFECTION AMONG RISK GROUPS IN EGYPT." AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 51 (1994): 563-567. Abstract
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ABDELWAHAB, MF, G. Esmat, M. Milad, S. ABDELRAZEK, and GT Strickland. "CHARACTERISTIC SONOGRAPHIC PATTERN OF SCHISTOSOMAL HEPATIC-FIBROSIS." AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 40 (1989): 72-76. Abstract
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ABDELWAHAB, MF, G. Esmat, A. FARRAG, YA ELBORAEY, and GT Strickland. "GRADING OF HEPATIC SCHISTOSOMIASIS BY THE USE OF ULTRASONOGRAPHY." AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 46 (1992): 403-408. Abstract
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ABDELWAHAB, MF, I. Ramzy, G. Esmat, H. ELKAFASS, and GT Strickland. "ULTRASOUND FOR DETECTING SCHISTOSOMA-HAEMATOBIUM URINARY-TRACT COMPLICATIONS - COMPARISON WITH RADIOGRAPHIC PROCEDURES." JOURNAL OF UROLOGY 148 (1992): 346-350. Abstract
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ABDELWAHAB, MF, A. YOSERY, S. Narooz, G. Esmat, S. ELHAK, S. NASIF, and GT Strickland. "IS SCHISTOSOMA-MANSONI REPLACING SCHISTOSOMA-HAEMATOBIUM IN THE FAYOUM." AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 49 (1993): 697-700. Abstract
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ABDELWAHAB, MF, G. Esmat, SI NAROOZ, A. YOSERY, JP STRUEWING, and GT Strickland. "SONOGRAPHIC STUDIES OF SCHOOLCHILDREN IN A VILLAGE ENDEMIC FOR SCHISTOSOMA-MANSONI." TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE 84 (1990): 69-73. Abstract
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ABDELWAHAB, MF, G. Esmat, I. Ramzy, R. Fouad, M. ABDELRAHMAN, A. YOSERY, S. Narooz, and GT Strickland. "SCHISTOSOMA-HAEMATOBIUM INFECTION IN EGYPTIAN SCHOOLCHILDREN - DEMONSTRATION OF BOTH HEPATIC AND URINARY-TRACT MORBIDITY BY ULTRASONOGRAPHY." TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE 86 (1992): 406-409. Abstract
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Alboraie, Mohamed, Marwa Khairy, Marwa Elsharkawy, Noha Asem, Aisha Elsharkawy, and Gamal Esmat. "Value of Egy-Score in diagnosis of significant, advanced hepatic fibrosis and cirrhosis compared to aspartate aminotransferase-to-platelet ratio index, FIB-4 and Forns' index in chronic hepatitis C virus." Hepatology research : the official journal of the Japan Society of Hepatology (2014). Abstract

AIM: Serum markers and developed scores are of rising importance in non-invasive diagnosis of hepatic fibrosis. Aspartate aminotransferase-to-platelet ratio index (APRI), FIB-4 and Forns' index are validated scores used for diagnosis of liver fibrosis. The Egy-Score is a newly developed score for detection of hepatic fibrosis with promising results. We aimed to assess the accuracy of the Egy-Score in the diagnosis of significant fibrosis, advanced fibrosis and cirrhosis compared to APRI, FIB-4 and Forns' in chronic hepatitis C virus (HCV) patients.

METHODS: A retrospective study including 100 chronic hepatitis C naïve Egyptian patients was performed. Patients were classified according to stages of fibrosis into three groups: significant fibrosis (≥ F2), advanced fibrosis (≥ F3) and cirrhosis (F4). Egy-Score, APRI, FIB-4 and Forns' index were calculated. Regression analysis and receiver-operator curves were plotted to assess the sensitivity, specificity and predictive values for the significant scores with the best cut-off for diagnosis.

RESULTS: An Egy-Score of 3.28 or more was superior to APRI, FIB-4 and Forns' index for detecting advanced fibrosis with a sensitivity of 91% and specificity of 78%. An Egy-Score of 3.67 or more was superior to APRI, FIB-4 and Forns' index for detecting cirrhosis with a sensitivity of 82% and specificity of 87%. Forns' index was superior to Egy-Score, FIB-4 and APRI for detecting significant fibrosis.

CONCLUSION: The Egy-Score is a promising, accurate, easily calculated, cost-effective score in the prediction of hepatic fibrosis in chronic HCV patients with superiority over APRI, FIB-4 and Forns' index in advanced hepatic fibrosis and cirrhosis.

Alboraie, Mohamed, Marwa Khairy, Aisha Elsharkawy, Marwa Elsharkawy, Noha Asem, Amany R. Abo El-Seoud, Fathy G. Elghamry, and Gamal Esmat. "Egy-score as a noninvasive score for the assessment of hepatic fibrosis in chronic hepatitis C: a preliminary approach." Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association 20, no. 3 (2014): 170-4. Abstract

BACKGROUND AND AIMS: Egy-Score is a new noninvasive score for prediction of severe hepatic fibrosis in patients with chronic liver diseases. The aim of this study was to validate Egy-Score as a noninvasive score for predicting stage of hepatic fibrosis in a group of Egyptian chronic hepatitis C patients.

PATIENTS AND METHODS: One hundred Egyptian patients with chronic hepatitis C were enrolled. Mean age was 40.25 ± 9.39 years. They were subjected to CA19-9, alpha-2-macroglobulin, total bilirubin, platelet count and albumin, liver biopsy, and histopathological staging of hepatic fibrosis according to METAVIR scoring system as part of their assessment for treatment. Egy-Score was calculated according to the following formula: Egy-Score = 3.52 + 0.0063 × CA19-9 + 0.0203 × age + 0.4485 × alpha-2-macroglobulin + 0.0303 × bilirubin - 0.0048 × platelet - 0.0462 × albumin. Egy-Score results were correlated to the stage of hepatic fibrosis.

RESULTS: Egy-Score correlates positively with the stage of hepatic fibrosis (F0-F4). Egy-Score was able to differentiate significant hepatic fibrosis, severe hepatic fibrosis, and cirrhosis accurately. Cutoff values of Egy-Score were 2.91850 (for significant fibrosis), 3.28624 (for severe fibrosis), and 3.67570 (for cirrhosis). Sensitivity, specificity, and areas-under-ROC curve (AUROCs) were 75.8%, 68.42%, and 0.776 (for significant fibrosis "≥F2"), 91.67%, 77.63%, and 0.875 (for severe fibrosis "≥F3"), and 81.82%, 86.52%, and 0.874 (for cirrhosis "F4"), respectively.

CONCLUSION: Egy-Score is a useful noninvasive panel of surrogate biomarkers that could accurately predict different stages of hepatic fibrosis in patients with chronic hepatitis C.

Ashour, Mohamed K., Maissa E. Elraziky, Wafaa A. ElAkel, Amr Eldeeb, Mohamed Abdel-Hamid, Sherif El Kafrawy, Hani M. Khattab, and Gamal E. Esmat. "SAFETY, DOSAGE AND EFFICACY OF A NOVEL Y SHAPED MOLECULE OF PEGYLATED INTERFERON ALPHA 2A FOR TREATMENT OF CHRONIC HCV." HEPATOLOGY 54 (2011): 1006A. Abstract
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Assal, R., Mohamed H. El Tayebi, Adel K. Hosny, G. Esmat, and Ihab A. Abdelaziz. "Failure of induction of the oncomiRic cluster miR-182/miR-96 in HCV-induced non-metastatic hepatocellular carcinoma tissues renders them as markers for metastasis." VIRCHOWS ARCHIV 463 (2013): 125. Abstract
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B
Bakr, I., C. Rekacewicz, M. El Hosseiny, S. Ismail, M. El Daly, S. El-Kafrawy, G. Esmat, MA Hamid, M. K. Mohamed, and A. Fontanet. "Higher clearance of hepatitis C virus infection in females compared with males." GUT 55 (2006): 1183-1187. Abstract
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BASSILY, S., GT Strickland, MF ABDELWAHAB, G. E. Esmat, S. Narooz, NA ELMASRY, NT CONSTANTINE, and JP STRUEWING. "EFFICACY OF HEPATITIS-B VACCINATION IN PRIMARY-SCHOOL CHILDREN FROM A VILLAGE ENDEMIC FOR SCHISTOSOMA-MANSONI." JOURNAL OF INFECTIOUS DISEASES 166 (1992): 265-268. Abstract
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