Publications

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2012
Hamdi, N., W. El-Akel, M. El-Serafy, G. Esmat, C. Sarrazin, and A. I. Abdelaziz. "Transcriptional Response of MxA, PKR and SOCS3 to Interferon-Based Therapy in HCV Genotype 4-Infected Patients and Contribution of p53 to Host Antiviral Response." INTERVIROLOGY 55 (2012): 210-218. Abstract
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Abbas, Emad, Olfat Shaker, Ghada Abd El Aziz, Huda Ramadan, and Gamal Esmat. "Epidermal growth factor gene polymorphism 61A/G in patients with chronic liver disease for early detection of hepatocellular carcinoma: a pilot study." EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 24 (2012): 458-463. Abstract
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Elsharkawy, A., G. Esmat, M. El Raziky, W. Elakel, M. Abdel-Rahman, and M. Elsayed. "HCV/SCHISTOSOMIASIS COINFECTION: IMPACT ON FIBROSIS AND RESPONSE TO PEGYLATED INTERFERON AND RIBAVIRIN THERAPY." JOURNAL OF HEPATOLOGY 56 (2012): S61. Abstract
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Yosry, Ayman, Mohamed Said, Gamal Esmat, Magdy Al-Serafy, Ashraf Omar, Wahid Doss, Dalia Omran, Yasmin Saad, Sanna Kamel, Akram Abdel-Bary et al. "HLA Tissue Typing Has No Effect on the Outcome of Patients Undergoing a Living-donor Liver Transplant: A Single-center Experience in Egypt." EXPERIMENTAL AND CLINICAL TRANSPLANTATION 10 (2012): 136-140. Abstract
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El Tayebi, H. M., K. A. Hosny, G. Esmat, K. Breuhahn, and A. I. Abdelaziz. "MIR-155 IS AN INDUCER FOR THE INSULIN-LIKE GROWTH FACTOR II MITOGENIC SIGNALING PATHWAY IN HCV-PROGRESSED HEPATOCELLULAR CARCINOMA." JOURNAL OF HEPATOLOGY 56 (2012): S112. Abstract
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El-Shamy, Ahmed, Ikuo Shoji, Wafaa El-Akel, Shymaa E. Bilasy, Lin Deng, Maissa El-Raziky, Da-peng Jiang, Gamal Esmat, and Hak Hotta. "NS5A Sequence Heterogeneity of Hepatitis C Virus Genotype 4a Predicts Clinical Outcome of Pegylated-Interferon-Ribavirin Therapy in Egyptian Patients." JOURNAL OF CLINICAL MICROBIOLOGY 50 (2012): 3886-3892. Abstract
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Fawzy, I. O., M. Negm, R. Ahmed, G. Esmat, N. Hamdi, and A. I. Abdelaziz. "Tamoxifen alleviates hepatitis C virus-induced inhibition of both toll-like receptor 7 and JAK-STAT signalling pathways in PBMCs of infected Egyptian females." JOURNAL OF VIRAL HEPATITIS 19 (2012): 854-861. Abstract
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Esmat, G., M. El Raziky, M. El Kassas, M. Hassany, and M. E. Gamil. "The future for the treatment of genotype 4 chronic hepatitis C." LIVER INTERNATIONAL 32 (2012): 146-150. Abstract
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Wiersma, S. T., B. McMahon, J. M. Pawlotsky, C. L. Thio, M. Thursz, S. G. Lim, P. Ocama, G. Esmat, M. Mendy, D. Bell et al. "Treatment of chronic hepatitis B virus infection in resource-constrained settings: expert panel consensus (vol 31, pg 755, 2011)." LIVER INTERNATIONAL 32 (2012): 174. Abstract
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Esmat, G., M. El-Bendary, S. Zakarya, M. A. Ela, and K. Zalata. "Role of Helicobacter pylori in patients with HCV-related chronic hepatitis and cirrhosis with or without hepatocellular carcinoma: possible association with disease progression." JOURNAL OF VIRAL HEPATITIS 19 (2012): 473-479. Abstract
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Mekky, Radwa Y., Nabila Hamdi, Wafaa El-Akel, Gamal Esmat, and Ahmed I. Abdelaziz. "Estrogen-related MxA transcriptional variation in hepatitis C virus-infected patients." TRANSLATIONAL RESEARCH 159 (2012): 190-196. Abstract
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Esmat, Gamal, Mohamed Hashem, Mona El-Raziky, Wafaa El-Akel, Suzan El-Naghy, Nehal El-Koofy, Rokaya El-Sayed, Rasha Ahmed, Mohamed Atta-Allah, Mohamed Abdel Hamid et al. "Risk factors for hepatitis C virus acquisition and predictors of persistence among Egyptian children." LIVER INTERNATIONAL 32 (2012): 449-456. Abstract
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Fathalla, Waleed, Wafaa El-Akel, Ahmad Salama, Gamal Esmat, and Mahasen Mabrouk. "The Effect of Peginterferon ALPHA-2A vs. Peginterferon alpha-2B in Treatment of NaiVE Chronic HCV Genotype-4 Patients: A Cohort Egyptian Study." GASTROENTEROLOGY 142 (2012): S939. Abstract
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Khairy, Marwa, Mahassen Abdel-Rahman, Maissa El-Raziky, Wafaa El-Akel, Naglaa Zayed, Hany Khatab, and Gamal Esmat. "Non-Invasive Prediction of Hepatic Fibrosis in Patients With Chronic HCV Based on the Routine Pre-Treatment Workup." HEPATITIS MONTHLY 12 (2012). Abstract
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Mabrouk, Mahasen, Gamal Esmat, Ayman Yosry, Magdy El-Serafy, Wahid Doss, Naglaa Zayed, Medhat El-Sahhar, Sally Awny, and Ashraf Omar. "Health-related quality of life in Egyptian patients after liver transplantation." ANNALS OF HEPATOLOGY 11 (2012): 882-890. Abstract
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Hezode, Christophe, Gideon M. Hirschfield, Wayne Ghesquiere, William Sievert, Maribel Rodriguez-Torres, Stephen D. Shafran, Paul J. Thuluvath, Harvey A. Tatum, Imam Waked, Gamal E. Esmat et al. "Daclatasvir, an NS5A Replication Complex Inhibitor, Combined With Peginterferon Alfa-2a and Ribavirin in Treatment-Naive HCV-Genotype 1 or 4 Subjects: Phase 2b COMMAND-1 SVR12 Results." HEPATOLOGY 56 (2012): 553A-554A. Abstract
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Obach, Dorothee, Yazdan Yazdanpanah, Gamal E. Esmat, Valerie Canva-Delcambre, Sahar Dewedar, Wagida A. Anwar, Wahid H. Doss, Aya Mostafa, Stanislas Pol, Maria Buti et al. "Impact of different treatment scale-up and eligibility scenarios on HCV mortality in egypt in the next five years." HEPATOLOGY 56 (2012): 1012A. Abstract
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Saad, Yasmin, Mohamed Said, Yasser Nassar, Gamal E. Esmat, and Olfat G. Shaker. "Microsomal Triglyceride Transfer Protein (MTP) polymorphism as marker for prediction of response to antiviral therapy in Egyptian patients with chronic HCV genotype 4." HEPATOLOGY 56 (2012): 1005A. Abstract
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Zayed, Naglaa, Gamal Esmat, Wafaa A. ElAkel, Tahany Awad, and Mahasen Mabrouk. "Therapeutic Outcome in 6198 Interferon-Naive Egyptian Patients with Chronic Hepatitis C genotype-4: A Real Experience." HEPATOLOGY 56 (2012): 1016A. Abstract
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Yosry, Ayman, Rabab F. Omar, Mohamed Ezz Al Arab, Hanan Abdel-Hafez, Mohamed Gohar, and Gamal Esmat. "Transient Elastography Can Predict the Risk of Hepatocellular Carcinoma in Patients with Chronic Hepatitis C." HEPATOLOGY 56 (2012): 844A. Abstract
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Fathy, A., L. Metwally, M. Abdel-Rehim, G. Essmat, M. Eida, and Mohy M. Eldeen. "Interferon therapy shifts natural killer subsets among Egyptian patients with chronic hepatitis C." JOURNAL OF VIRAL HEPATITIS 19 (2012): 12. Abstract
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El Tayebi, H. M., K. A. Hosny, G. Esmat, K. Breuhahn, and Ahmed Ihab Abdelaziz. "miR-615-5p is restrictedly expressed in cirrhotic and cancerous liver tissues and its overexpression alleviates the tumorigenic effects in hepatocellular carcinoma." FEBS LETTERS 586 (2012): 3309-3316. Abstract
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2013
Shaker, Olfat, Heba Bassiony, Maissa El Raziky, Samer S. El-Kamary, Gamal Esmat, Akmal M. El-Ghor, and Mona M. Mohamed. "Human Leukocyte Antigen Class II Alleles (DQB1 and DRB1) as Predictors for Response to Interferon Therapy in HCV Genotype 4." MEDIATORS OF INFLAMMATION (2013). Abstract
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Mabrouk, Mahasen, Maissa El-Raziky, Naglaa Zayed, Rabab Salama, Wafaa El-Akel, Tahany Awad, Mohammad El Beshlawy, and Gamal Esmat. "Clinical, biochemical and pathological profiles of 5464 Egyptian chronic hepatitis C-infected patients." Hepato-gastroenterology 60, no. 127 (2013): 1731-5. Abstract

BACKGROUND/AIMS: In Egypt, hepatitis C virus (HC is highly endemic with at least 91% are genotype-4. However, HCV-specific burden data for Egypt are scarce. The study aims to identify clinical, biochemical and pathological features of chronic HCV population in Egypt.

METHODOLOGY: We analyzed retrospective data of 5,464 HCV-antibody and PCR positive patients attending pre-treatment assessment at one of the National Treatment Centers, Cairo, Egypt.

RESULTS: Chronic HCV patients were males (81.4%) in their productive age, mean body mass index (BMI): 28 kg/m2. Laboratory profile demonstrated mean platelet count 214 x 10(3)/µ L with only 14% having thrombocytopenia, amino-transferases were mildly elevated: mean AST, ALT were 56 and 63 respectively,low viraemia: 50% had viral load <100 (x 10(3)) IU/mL,and median AFP level 3.3 ng/mL. Liver biopsy revealed ≤A2 in 92% of patients; 80% had ≤F2 and 7.3 % had F4 according to the METAVIR score. Meta regression demonstrated that advanced stages of fibrosis were significantly correlated with platelet count, AST/ALT ratio, AFP levels and BMI (p <0.001). However there was no correlation with viral load.

CONCLUSIONS: To our knowledge, this is the first study on nationwide scale that provided the demographic, biochemical,and histological characteristics for this number of chronic HCV patients presumably genotype-4.

Mohsen, A., E. M. Ibrahim, S. Al Aidi, S. El Mango, A. Bernier, M. El Daly, M. El Gafaary, Abdel M. Hamid, G. Esmat, M. Gadallah et al. "COMMUNITY TRANSMISSION OF HEPATITIS C VIRUS AMONG EGYPTIANS: ANALYSIS OF A 10 YEARS CASE-CONTROL STUDY." JOURNAL OF HEPATOLOGY 58 (2013): S398. Abstract
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