Publications

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2012
Hamdi, N., W. El-Akel, M. El-Serafy, G. Esmat, C. Sarrazin, and A. I. Abdelaziz. "Transcriptional Response of MxA, PKR and SOCS3 to Interferon-Based Therapy in HCV Genotype 4-Infected Patients and Contribution of p53 to Host Antiviral Response." INTERVIROLOGY 55 (2012): 210-218. Abstract
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Abbas, Emad, Olfat Shaker, Ghada Abd El Aziz, Huda Ramadan, and Gamal Esmat. "Epidermal growth factor gene polymorphism 61A/G in patients with chronic liver disease for early detection of hepatocellular carcinoma: a pilot study." EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 24 (2012): 458-463. Abstract
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Elsharkawy, A., G. Esmat, M. El Raziky, W. Elakel, M. Abdel-Rahman, and M. Elsayed. "HCV/SCHISTOSOMIASIS COINFECTION: IMPACT ON FIBROSIS AND RESPONSE TO PEGYLATED INTERFERON AND RIBAVIRIN THERAPY." JOURNAL OF HEPATOLOGY 56 (2012): S61. Abstract
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Yosry, Ayman, Mohamed Said, Gamal Esmat, Magdy Al-Serafy, Ashraf Omar, Wahid Doss, Dalia Omran, Yasmin Saad, Sanna Kamel, Akram Abdel-Bary et al. "HLA Tissue Typing Has No Effect on the Outcome of Patients Undergoing a Living-donor Liver Transplant: A Single-center Experience in Egypt." EXPERIMENTAL AND CLINICAL TRANSPLANTATION 10 (2012): 136-140. Abstract
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El Tayebi, H. M., K. A. Hosny, G. Esmat, K. Breuhahn, and A. I. Abdelaziz. "MIR-155 IS AN INDUCER FOR THE INSULIN-LIKE GROWTH FACTOR II MITOGENIC SIGNALING PATHWAY IN HCV-PROGRESSED HEPATOCELLULAR CARCINOMA." JOURNAL OF HEPATOLOGY 56 (2012): S112. Abstract
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El-Shamy, Ahmed, Ikuo Shoji, Wafaa El-Akel, Shymaa E. Bilasy, Lin Deng, Maissa El-Raziky, Da-peng Jiang, Gamal Esmat, and Hak Hotta. "NS5A Sequence Heterogeneity of Hepatitis C Virus Genotype 4a Predicts Clinical Outcome of Pegylated-Interferon-Ribavirin Therapy in Egyptian Patients." JOURNAL OF CLINICAL MICROBIOLOGY 50 (2012): 3886-3892. Abstract
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Fawzy, I. O., M. Negm, R. Ahmed, G. Esmat, N. Hamdi, and A. I. Abdelaziz. "Tamoxifen alleviates hepatitis C virus-induced inhibition of both toll-like receptor 7 and JAK-STAT signalling pathways in PBMCs of infected Egyptian females." JOURNAL OF VIRAL HEPATITIS 19 (2012): 854-861. Abstract
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Esmat, G., M. El Raziky, M. El Kassas, M. Hassany, and M. E. Gamil. "The future for the treatment of genotype 4 chronic hepatitis C." LIVER INTERNATIONAL 32 (2012): 146-150. Abstract
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Wiersma, S. T., B. McMahon, J. M. Pawlotsky, C. L. Thio, M. Thursz, S. G. Lim, P. Ocama, G. Esmat, M. Mendy, D. Bell et al. "Treatment of chronic hepatitis B virus infection in resource-constrained settings: expert panel consensus (vol 31, pg 755, 2011)." LIVER INTERNATIONAL 32 (2012): 174. Abstract
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Mekky, Radwa Y., Nabila Hamdi, Wafaa El-Akel, Gamal Esmat, and Ahmed I. Abdelaziz. "Estrogen-related MxA transcriptional variation in hepatitis C virus-infected patients." TRANSLATIONAL RESEARCH 159 (2012): 190-196. Abstract
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Esmat, Gamal, Mohamed Hashem, Mona El-Raziky, Wafaa El-Akel, Suzan El-Naghy, Nehal El-Koofy, Rokaya El-Sayed, Rasha Ahmed, Mohamed Atta-Allah, Mohamed Abdel Hamid et al. "Risk factors for hepatitis C virus acquisition and predictors of persistence among Egyptian children." LIVER INTERNATIONAL 32 (2012): 449-456. Abstract
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Fathalla, Waleed, Wafaa El-Akel, Ahmad Salama, Gamal Esmat, and Mahasen Mabrouk. "The Effect of Peginterferon ALPHA-2A vs. Peginterferon alpha-2B in Treatment of NaiVE Chronic HCV Genotype-4 Patients: A Cohort Egyptian Study." GASTROENTEROLOGY 142 (2012): S939. Abstract
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Khairy, Marwa, Mahassen Abdel-Rahman, Maissa El-Raziky, Wafaa El-Akel, Naglaa Zayed, Hany Khatab, and Gamal Esmat. "Non-Invasive Prediction of Hepatic Fibrosis in Patients With Chronic HCV Based on the Routine Pre-Treatment Workup." HEPATITIS MONTHLY 12 (2012). Abstract
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Mabrouk, Mahasen, Gamal Esmat, Ayman Yosry, Magdy El-Serafy, Wahid Doss, Naglaa Zayed, Medhat El-Sahhar, Sally Awny, and Ashraf Omar. "Health-related quality of life in Egyptian patients after liver transplantation." ANNALS OF HEPATOLOGY 11 (2012): 882-890. Abstract
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Hezode, Christophe, Gideon M. Hirschfield, Wayne Ghesquiere, William Sievert, Maribel Rodriguez-Torres, Stephen D. Shafran, Paul J. Thuluvath, Harvey A. Tatum, Imam Waked, Gamal E. Esmat et al. "Daclatasvir, an NS5A Replication Complex Inhibitor, Combined With Peginterferon Alfa-2a and Ribavirin in Treatment-Naive HCV-Genotype 1 or 4 Subjects: Phase 2b COMMAND-1 SVR12 Results." HEPATOLOGY 56 (2012): 553A-554A. Abstract
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Obach, Dorothee, Yazdan Yazdanpanah, Gamal E. Esmat, Valerie Canva-Delcambre, Sahar Dewedar, Wagida A. Anwar, Wahid H. Doss, Aya Mostafa, Stanislas Pol, Maria Buti et al. "Impact of different treatment scale-up and eligibility scenarios on HCV mortality in egypt in the next five years." HEPATOLOGY 56 (2012): 1012A. Abstract
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Zayed, Naglaa, Gamal Esmat, Wafaa A. ElAkel, Tahany Awad, and Mahasen Mabrouk. "Therapeutic Outcome in 6198 Interferon-Naive Egyptian Patients with Chronic Hepatitis C genotype-4: A Real Experience." HEPATOLOGY 56 (2012): 1016A. Abstract
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Yosry, Ayman, Rabab F. Omar, Mohamed Ezz Al Arab, Hanan Abdel-Hafez, Mohamed Gohar, and Gamal Esmat. "Transient Elastography Can Predict the Risk of Hepatocellular Carcinoma in Patients with Chronic Hepatitis C." HEPATOLOGY 56 (2012): 844A. Abstract
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Fathy, A., L. Metwally, M. Abdel-Rehim, G. Essmat, M. Eida, and Mohy M. Eldeen. "Interferon therapy shifts natural killer subsets among Egyptian patients with chronic hepatitis C." JOURNAL OF VIRAL HEPATITIS 19 (2012): 12. Abstract
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El Tayebi, H. M., K. A. Hosny, G. Esmat, K. Breuhahn, and Ahmed Ihab Abdelaziz. "miR-615-5p is restrictedly expressed in cirrhotic and cancerous liver tissues and its overexpression alleviates the tumorigenic effects in hepatocellular carcinoma." FEBS LETTERS 586 (2012): 3309-3316. Abstract
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2013
Shaker, Olfat, Heba Bassiony, Maissa El Raziky, Samer S. El-Kamary, Gamal Esmat, Akmal M. El-Ghor, and Mona M. Mohamed. "Human Leukocyte Antigen Class II Alleles (DQB1 and DRB1) as Predictors for Response to Interferon Therapy in HCV Genotype 4." MEDIATORS OF INFLAMMATION (2013). Abstract
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Mabrouk, Mahasen, Maissa El-Raziky, Naglaa Zayed, Rabab Salama, Wafaa El-Akel, Tahany Awad, Mohammad El Beshlawy, and Gamal Esmat. "Clinical, biochemical and pathological profiles of 5464 Egyptian chronic hepatitis C-infected patients." Hepato-gastroenterology 60, no. 127 (2013): 1731-5. Abstract

BACKGROUND/AIMS: In Egypt, hepatitis C virus (HC is highly endemic with at least 91% are genotype-4. However, HCV-specific burden data for Egypt are scarce. The study aims to identify clinical, biochemical and pathological features of chronic HCV population in Egypt.

METHODOLOGY: We analyzed retrospective data of 5,464 HCV-antibody and PCR positive patients attending pre-treatment assessment at one of the National Treatment Centers, Cairo, Egypt.

RESULTS: Chronic HCV patients were males (81.4%) in their productive age, mean body mass index (BMI): 28 kg/m2. Laboratory profile demonstrated mean platelet count 214 x 10(3)/µ L with only 14% having thrombocytopenia, amino-transferases were mildly elevated: mean AST, ALT were 56 and 63 respectively,low viraemia: 50% had viral load <100 (x 10(3)) IU/mL,and median AFP level 3.3 ng/mL. Liver biopsy revealed ≤A2 in 92% of patients; 80% had ≤F2 and 7.3 % had F4 according to the METAVIR score. Meta regression demonstrated that advanced stages of fibrosis were significantly correlated with platelet count, AST/ALT ratio, AFP levels and BMI (p <0.001). However there was no correlation with viral load.

CONCLUSIONS: To our knowledge, this is the first study on nationwide scale that provided the demographic, biochemical,and histological characteristics for this number of chronic HCV patients presumably genotype-4.

Mohsen, A., E. M. Ibrahim, S. Al Aidi, S. El Mango, A. Bernier, M. El Daly, M. El Gafaary, Abdel M. Hamid, G. Esmat, M. Gadallah et al. "COMMUNITY TRANSMISSION OF HEPATITIS C VIRUS AMONG EGYPTIANS: ANALYSIS OF A 10 YEARS CASE-CONTROL STUDY." JOURNAL OF HEPATOLOGY 58 (2013): S398. Abstract
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