Publications

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2013
Esmat, Gamal, Mohamed El Kassas, Mohamed Hassany, Mohamed Esmat Gamil, and Maisa El Raziky. "How to optimize HCV therapy in genotype 4 patients." LIVER INTERNATIONAL 33 (2013): 41-45. Abstract
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Ragab, Dina, Melissa Laird, Darragh Duffy, Armanda Casrouge, Rasha Mamdouh, Amal Abass, Dina El Shenawy, Abdelhadi M. Shebl, Wagdi F. Elkashef, Khaled R. Zalata et al. "CXCL10 antagonism and plasma sDPPIV correlate with increasing liver disease in chronic HCV genotype 4 infected patients." CYTOKINE 63 (2013): 105-112. Abstract
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Assal, R., Mohamed H. El Tayebi, Adel K. Hosny, G. Esmat, and Ihab A. Abdelaziz. "Failure of induction of the oncomiRic cluster miR-182/miR-96 in HCV-induced non-metastatic hepatocellular carcinoma tissues renders them as markers for metastasis." VIRCHOWS ARCHIV 463 (2013): 125. Abstract
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El-Kamary, Samer S., Mona M. Mohamed, Maissa El-Raziky, Michelle D. Shardell, Olfat G. Shaker, Wafaa A. ElAkel, and Gamal Esmat. "Liver fibrosis staging through a stepwise analysis of non-invasive markers (FibroSteps) in patients with chronic hepatitis C infection." LIVER INTERNATIONAL 33 (2013): 982-990. Abstract
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Habashy, D., Mohamed H. El Tayebi, Adel K. Hosny, G. Esmat, and Ihab A. Abdelaziz. "MicroRNA-17-5p promotes tumorgenesis through the repression of IGFBP-3 and enhancement of insulin like growth factor signaling." VIRCHOWS ARCHIV 463 (2013): 322. Abstract
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Tayel, Sara S., Amal A. Helmy, Rasha Ahmed, Gamal Esmat, Nabila Hamdi, and Ahmed Ihab Abdelaziz. "Progesterone suppresses interferon signaling by repressing TLR-7 and MxA expression in peripheral blood mononuclear cells of patients infected with hepatitis C virus." ARCHIVES OF VIROLOGY 158 (2013): 1755-1764. Abstract
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Hatzakis, A., P. Van Damme, K. Alcorn, C. Gore, M. Benazzouz, S. Berkane, M. Buti, M. Carballo, H. Cortes Martins, S. Deuffic-Burban et al. "The State of Hepatitis B and C in the Mediterranean and Balkan Countries: Report from a Summit Conference." JOURNAL OF VIRAL HEPATITIS 20 (2013): 1-20. Abstract
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Mohsen, A., E. M. Ibrahim, S. Al Aidi, S. El Mango, A. Bernier, M. El Daly, M. El Gafaary, Abdel M. Hamid, G. Esmat, M. Gadallah et al. "COMMUNITY TRANSMISSION OF HEPATITIS C VIRUS AMONG EGYPTIANS: ANALYSIS OF A 10 YEARS CASE-CONTROL STUDY." JOURNAL OF HEPATOLOGY 58 (2013): S398. Abstract
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El-Sayed, M., M. El-Raziky, A. Elsharkawy, H. Khattab, A. H. K. Abdelmaksoud, M. K. Ashour, and G. Esmat. "COMPARISON BETWEEN DIFFUSION-WEIGHTED MRI, FIBROSCAN AND HISTOPATHOLOGY FOR ASSESSMENT OF LIVER FIBROSIS IN CHRONIC HCV PATIENTS." JOURNAL OF HEPATOLOGY 58 (2013): S185. Abstract
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Bonnard, P., M. El-Kassas, M. Gamal, A. B. Hassan, L. Le Fouler, A. Elsharkawy, E. Delarocque-Astagneau, M. El-Sayed, A. Abd El Hay, M. Abdel-Hamid et al. "COMPARISON OF LIVER BIOPSY, ELASTOMETRY AND SERUM MARKERS FOR LIVER FIBROSIS ASSESSMENT IN GENOTYPE 4 HCV-INFECTED PATIENTS IN EGYPT. RESULTS OF THE ANRS12184 STUDY." JOURNAL OF HEPATOLOGY 58 (2013): S287. Abstract
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Zekri, A. - R., H. Shousha, A. Nassar, N. Zayed, G. Esmat, A. Abdel-Aziz, and A. Kaseb. "GENE METHYLATION MARKERS FOR EGYPTIAN PATIENTS WITH HEPATOCELLULAR CARCINOMA." JOURNAL OF HEPATOLOGY 58 (2013): S256. Abstract
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Waly, A., H. M. El Tayebi, K. A. Hosny, G. Esmat, and A. I. Abdelaziz. "HYPERMETHYLATION OF THE microRNA LET-7A-3 GENE REPRESSES THE PRIMARY AND MATURE LET-7A-3 WITH AN INVERSE CORRELATION TO IGF-II mRNA IN HCV-INDUCED HEPATOCELLULAR CARCINOMA." JOURNAL OF HEPATOLOGY 58 (2013): S448-S449. Abstract
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Obach, D., S. Deuffic-Burban, G. Esmat, W. A. Anwar, S. Dewedar, V. Canva, A. Cousien, W. Doss, A. Mostafa, S. Pol et al. "IMMEDIATE vs. DELAYED TREATMENT IN GENOTYPE 4-HCV INFECTED PATIENTS IN A LIMITED RESOURCES COUNTRY: A COST-EFFECTIVENESS ANALYSIS IN EGYPT (ANRS 12215)." JOURNAL OF HEPATOLOGY 58 (2013): S364. Abstract
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Breban, R., N. Arafa, S. Leroy, A. Mostafa, I. Bakr, M. Adbel-Hamid, G. Esmat, M. K. Mohamed, and A. Fontanet. "IMPACT OF MASS ANTIVIRAL TREATMENT ON HCV TRANSMISSION IN RURAL EGYPT." JOURNAL OF HEPATOLOGY 58 (2013): S23. Abstract
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El Raziky, M., A. B. Awad, M. Youssef, A. Awad, A. Elsharkawi, G. Esmat, M. Mustafa, and M. Mabrouk. "A NOVEL PREDICTION MODEL FOR LIVER FIBROSIS IN PATIENTS WITH CHRONIC HEPATITIS C VIRUS USING FIBROSCAN AND ROUTINE LABORATORY DATA." JOURNAL OF HEPATOLOGY 58 (2013): S184. Abstract
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Breban, R., W. Doss, G. Esmat, M. Elsayed, M. Hellard, P. Ayscue, M. Albert, A. Fontanet, and M. K. Mohamed. "Towards realistic estimates of HCV incidence in Egypt." JOURNAL OF VIRAL HEPATITIS 20 (2013): 294-296. Abstract
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Mabrouk, Mahasen, Maissa El-Raziky, Naglaa Zayed, Rabab Salama, Wafaa El-Akel, Tahany Awad, Mohammad El Beshlawy, and Gamal Esmat. "Clinical, biochemical and pathological profiles of 5464 Egyptian chronic hepatitis C-infected patients." Hepato-gastroenterology 60, no. 127 (2013): 1731-5. Abstract

BACKGROUND/AIMS: In Egypt, hepatitis C virus (HC is highly endemic with at least 91% are genotype-4. However, HCV-specific burden data for Egypt are scarce. The study aims to identify clinical, biochemical and pathological features of chronic HCV population in Egypt.

METHODOLOGY: We analyzed retrospective data of 5,464 HCV-antibody and PCR positive patients attending pre-treatment assessment at one of the National Treatment Centers, Cairo, Egypt.

RESULTS: Chronic HCV patients were males (81.4%) in their productive age, mean body mass index (BMI): 28 kg/m2. Laboratory profile demonstrated mean platelet count 214 x 10(3)/µ L with only 14% having thrombocytopenia, amino-transferases were mildly elevated: mean AST, ALT were 56 and 63 respectively,low viraemia: 50% had viral load <100 (x 10(3)) IU/mL,and median AFP level 3.3 ng/mL. Liver biopsy revealed ≤A2 in 92% of patients; 80% had ≤F2 and 7.3 % had F4 according to the METAVIR score. Meta regression demonstrated that advanced stages of fibrosis were significantly correlated with platelet count, AST/ALT ratio, AFP levels and BMI (p <0.001). However there was no correlation with viral load.

CONCLUSIONS: To our knowledge, this is the first study on nationwide scale that provided the demographic, biochemical,and histological characteristics for this number of chronic HCV patients presumably genotype-4.

Shaker, Olfat, Heba Bassiony, Maissa El Raziky, Samer S. El-Kamary, Gamal Esmat, Akmal M. El-Ghor, and Mona M. Mohamed. "Human Leukocyte Antigen Class II Alleles (DQB1 and DRB1) as Predictors for Response to Interferon Therapy in HCV Genotype 4." MEDIATORS OF INFLAMMATION (2013). Abstract
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2012
El Tayebi, H. M., K. A. Hosny, G. Esmat, K. Breuhahn, and Ahmed Ihab Abdelaziz. "miR-615-5p is restrictedly expressed in cirrhotic and cancerous liver tissues and its overexpression alleviates the tumorigenic effects in hepatocellular carcinoma." FEBS LETTERS 586 (2012): 3309-3316. Abstract
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Fathy, A., L. Metwally, M. Abdel-Rehim, G. Essmat, M. Eida, and Mohy M. Eldeen. "Interferon therapy shifts natural killer subsets among Egyptian patients with chronic hepatitis C." JOURNAL OF VIRAL HEPATITIS 19 (2012): 12. Abstract
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Hezode, Christophe, Gideon M. Hirschfield, Wayne Ghesquiere, William Sievert, Maribel Rodriguez-Torres, Stephen D. Shafran, Paul J. Thuluvath, Harvey A. Tatum, Imam Waked, Gamal E. Esmat et al. "Daclatasvir, an NS5A Replication Complex Inhibitor, Combined With Peginterferon Alfa-2a and Ribavirin in Treatment-Naive HCV-Genotype 1 or 4 Subjects: Phase 2b COMMAND-1 SVR12 Results." HEPATOLOGY 56 (2012): 553A-554A. Abstract
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Obach, Dorothee, Yazdan Yazdanpanah, Gamal E. Esmat, Valerie Canva-Delcambre, Sahar Dewedar, Wagida A. Anwar, Wahid H. Doss, Aya Mostafa, Stanislas Pol, Maria Buti et al. "Impact of different treatment scale-up and eligibility scenarios on HCV mortality in egypt in the next five years." HEPATOLOGY 56 (2012): 1012A. Abstract
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Saad, Yasmin, Mohamed Said, Yasser Nassar, Gamal E. Esmat, and Olfat G. Shaker. "Microsomal Triglyceride Transfer Protein (MTP) polymorphism as marker for prediction of response to antiviral therapy in Egyptian patients with chronic HCV genotype 4." HEPATOLOGY 56 (2012): 1005A. Abstract
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Zayed, Naglaa, Gamal Esmat, Wafaa A. ElAkel, Tahany Awad, and Mahasen Mabrouk. "Therapeutic Outcome in 6198 Interferon-Naive Egyptian Patients with Chronic Hepatitis C genotype-4: A Real Experience." HEPATOLOGY 56 (2012): 1016A. Abstract
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Yosry, Ayman, Rabab F. Omar, Mohamed Ezz Al Arab, Hanan Abdel-Hafez, Mohamed Gohar, and Gamal Esmat. "Transient Elastography Can Predict the Risk of Hepatocellular Carcinoma in Patients with Chronic Hepatitis C." HEPATOLOGY 56 (2012): 844A. Abstract
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