Publications

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2021
Saber, F. R., E. Mohsen, S. El-Hawary, B. M. Eltanany, H. Elimam, M. Sobeh, and A. K. Elmotayam, "Chemometric-enhanced metabolic profiling of five Pinus species using HPLC-MS/MS spectrometry: Correlation to in vitro anti-aging, anti-Alzheimer and antidiabetic activities.", Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, vol. 1177, pp. 122759, 2021. Abstract

Detailed metabolic profiling of needles of five Pinus species was investigated using complementary HPLC-MS/MS techniques together with supervised and unsupervised chemometric tools. This resulted in putative identification of 44 compounds belonging to flavonoids, phenolics, lignans, diterpenes and fatty acids. Unsupervised principal component analysis showed that differences were maintained across the metabolites characteristic of each Pinus species, are mainly related to di-O-p-coumaroyltrifolin, p-coumaroyl quinic acid derivative, arachidonic acid, hydroxypalmitic acid, isopimaric acid and its derivative. A supervised Partial Least Squares regression analysis was performed to correlate HPLC-MS/MS profiles with the variation observed in the in vitro anticholinesterase, antiaging and anti-diabetic potential. All investigated Pinus extracts exerted their antiaging activity via increasing telomerase and TERT levels in normal human melanocytes cells compared to the control (untreated cells). Profound inhibition activities of acetylcholinesterase and dipeptidyl peptidase-4 were also observed with P. pinea and P. canariensis extracts having comparable antidiabetic activities to sitagliptin as a standard antidiabetic drug. Our findings suggested that pine needles are a good source of phenolics and diterpenoids that have possible health promoting activities in management and alleviation of diabetic conditions and Alzheimer disease.

2020
Abouseadaa, H. H., M. A. M. Atia, I. Y. Younis, M. Y. Issa, H. A. Ashour, I. SALEH, G. H. Osman, I. A. Arif, and E. Mohsen, "Gene-targeted molecular phylogeny, phytochemical profiling, and antioxidant activity of nine species belonging to family Cactaceae.", Saudi journal of biological sciences, vol. 27, issue 6, pp. 1649-1658, 2020. Abstract

Cactaceae plant family comprises over 130 genera and 2000 species of succulent flowering plants. The genera and (), which have medicinal and nutritional applications as well as aesthetic appeal, are considered to be among the major genera of the family. Several species of both genera show morphological and chemical similarities and diversities according to environmental conditions and genotypes. Here, we assessed the genetic relationships of nine species belonging to two major genera and under the family Cactaceae, using two modern gene-targeting marker techniques, the Start Codon Targeted (SCoT) Polymorphism and the Conserved DNA-Derived Polymorphism (CDDP). Besides, we screened the various phytochemicals and evaluated the antioxidant activities of the nine species of cacti. Five out of the 10 SCoT and eight CDDP primers used to screen genetic variations within the nine species yielded species-specific reproducible bands. The entire 156 loci were detected, of which 107 were polymorphic, 26 were monomorphic, and 23 were unique loci. The nine species were categorized into two groups based on the dendrogram and similarity matrix. Phytochemical profiling revealed that sterols, triterpenes, flavonoids, and tannins were found in all the tested species. Additionally, two species ( and ) and one species () revealed a considerable antioxidant activity. Our results demonstrated that gene-targeting marker techniques were highly powerful tools for the classification and characterization of the nine investigated species, despite displaying high similarities at both morphological and phytochemical levels.

Issa, M. Y., E. Mohsen, I. Y. Younis, E. S. Nofal, and M. A. Farag, "Volatiles distribution in jasmine flowers taxa grown in Egypt and its commercial products as analyzed via solid-phase microextraction (SPME) coupled to chemometrics", Industrial Crops & Products, vol. 144, pp. 1-10, 2020.
2018
A.Farag, M., E. Mohsen, and A. E. N. G.El-Gendy, "Sensory metabolites profiling in Myristica fragrans (Nutmeg) organs and in response to roasting as analyzed via chemometric tools", LWT, vol. Volume 97, pp. Pages 684-692, 2018.
2015
Mohsen, E., Z. A. Kandil, R. A. Sallam, S. H.Tadros, and M. A. A. Kawy, "BOTANICAL CHARACTERIZATION OF PARKIA ROXBURGHII G. DON AND PARKIA BIGLOBOSA (JACQ.) BENTH CULTIVATED IN EGYPT", World Journal of Pharmaceutical Research, vol. 4, issue 5, pp. 159-190, 2015.