Publications

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1998
El-Bardicy, M. G., M. F. El-Tarras, and E. S. Elzanfaly, "Determination of phenytoin, phenobarbitone and methylphenobarbitone in combination.", Spectroscopy Letters, vol. 30, issue 2, pp. 267-287, 1998. Abstract

This work is concerned with the determination of a mixture of phenytoin, phenobarbitone and methylphenobarbitone by two Werent techniques. The first one depends on the simultaneous quantitative densitometric evaluation of thin layer chromatograms of the three drugs. The second is the application of quantitative 'H-NMR spectrometry for the simultaneous determination of phenobarbitone and methylphenobahiione in the presence of phenytoin, while phenytoin was determined in this
mixture by modifying the benzophenone spectrophotometric procedure

2002
Salem, M. Y., A. M. El-Kosasy, E. S. Elzanfaly, M. F. El-Tarras, and M. G. El-Bardicy, "Determination of chlorphenoxamine hydrochloride in the presence of caffeine and 8-chlorotheophylline by ion selective electrodes", Bull. Fac. Pharm. Cairo University, vol. 40, issue 3, pp. 1-10, 2002.
Salem, M. Y., E. S. Elzanfaly, M. G. El-Bardicy, and M. F. El-Tarras, "Simultaneous determination of domperidone maleate and cinnarizin in a binary mixture form by derivative ratio spectrophotometry and classical least squares calibration. ", Journal of Pharmaceutical and Biomedical Analysis, vol. 30, issue 1, pp. 21-33, 2002.
Salem, M. Y., E. S. Elzanfaly, M. F. El-Tarras, and M. G. El-Bardicy, "Simultaneous determination of domperidone maleate and cinnarizin in a binary mixture form by derivative spectrophotometry, partial least squares and principal component regression", Journal of Analytical and Bioanalytical Chem, vol. 30, issue 1, pp. 21-33, 2002.
2003
A., E., E. S. Elzanfaly, and N. N. Salama, "Ratio derivative spectrophotometic methods for the determination of some oxicams in the presence of their alkaline degradation products", Scientia Pharmaceutica , vol. 71, issue 4, pp. 303-320, 2003.
Salem, M. Y., E. S. El-zanfaly, M. F. El-Tarras, and M. G. El-Bardicy, "Stability indicating methods for the determination of metoclopramide and vitamin B6 simultaneously in a mixture form", Bull. Fac. Pharm. Cairo University , vol. 41, issue 1, pp. 1-10, 2003.
2010
Elzanfaly, E. S., M. N. Morkos, and N. K. Ramadan, "Development and validation of PCR, PLS and TLC densitometric methods for the determination of vitamins B1, B6 and B12 in pharmaceutical formulations", Pakistanian Journal of Pharmaceutical Sciences, vol. 23 , issue 4, pp. 409 - 415, 2010.
Ramadan, N. K., M. N. Morkos, and E. S. Elzanfaly, "Membrane electrodes for the simultaneous determination of vitamins B1, B6 and B12", Research & Reviews in ElectroChemistry, vol. 2 , issue 2, pp. 78-87, 2010.
2012
ElHamid, G. A., M. R. Elghobashy, E. S. ElZanfaly, S. M. Amer, and S. Z. ElKhateeb, "Ion selective membrane electrodes for stability-indicating determination of amisulpride", Anal Bioanal Electrochem, vol. 4, pp. 579–592, 2012. Abstract
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Elzanfaly, E. S., A. S. Saad, and A. - E. B. Abd-Elaleem, "Combining the isoabsorptive point in the ratio spectrum and the smart ratio difference methods for a single step determination of compounds with overlapped spectra", Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 95, pp. 188–192, 2012.
AbdElHamid, G., M. R. Elghobashy, E. S. Elzanfaly, S. M. Amer, and S. Z. ElKhateeb, "Ion Selective Membrane Electrodes for Stability Indicating Determination of Amisulpride", Anal. Bioanal. Electrochem. , vol. 4, issue 6, pp. 579 – 592, 2012.
Elzanfaly, E. S., A. S. Saad, and A. - E. B. Abd-Elaleem, "A Novel Simple Method for Resolving Overlapped Spectral Data with A Wide Range of Applicability, and Its Application as a Stability Indicating Method for Determination of Tazarotene ", Pharmaceutica Anaytical Acta, , vol. 3, issue 3, pp. 153, 2012.
Elzanfaly, E. S., A. S. Saad, and A. - E. B. Abd-Elaleem, "Simultaneous determination of retinoic acid and hydroquinone in skin ointment using spectrophotometric technique (ratio difference method)", Saudi Pharmaceutical Journal, vol. 20, pp. 249–253, 2012.
Elzanfaly, E. S., A. S.Saad, and A. E. B. A. Elaleem, "A smart simple spectrophotometric method for simultaneous determination of binary mixtures", Journal of Pharmceutical Analysis, vol. 2 , issue 5, 2012.
2013
, "Ion Selective Membrane Electrodes for Stability Indicating Determination of Benoxinate Hydrochloride in Pure form and in Drug Product", Anal. Bioanal. Electrochem. , vol. 5, issue 2, pp. 166 - 177, 2013. Abstract

This paper presents a comparative study between four sensors
constructed to determine benoxinate hydrochloride (BX) in the presence of its hydrolysis
induced degradation product using different ion association complexes and plasticizers.
Precipitation based technique was used for sensors fabrication. The BX complexes with the
cationic exchangers; BX- reinikate, BX-tetraphenylborate, BX-phosphotungestate, and BXtetrakis
were obtained in situ by soaking the PVC membranes in 1×10-2 BX solution.
Dioctylphthalate and nitrophenyl octyl ether were used as solvent mediators. The proposed
sensors showed fast, stable Nernstian responses across a relatively wide BX concentration
range (5×10-5 to 10-1 M) in the pH range of 4-6. The suggested sensors could be used for
several weeks without any measurable change in sensitivity. They displayed good selectivity
for BX in presence of its degradation product, common inorganic and organic species. The
proposed sensors were successfully applied for the determination of BX in pure powder form
and eye drops where good recoveries were obtained.

Elzanfaly, E. S., H. E. Zaazaa, and H. A. Merey, "Ion Selective Phosphotungestate and β-cyclodextrin Based Membrane Electrodes for Stability-Indicating Determination of Midodrine Hydrochloride", Acta Chim. Slov., vol. 60 , issue 2, pp. 256–262, 2013. Abstract

This paper reports the construction and evaluation of two ion selective electrodes for the determination midodrine hydrochloride (MD) by direct potentiometry in pure drug substance and in tablet formulations. Precipitation based technique was used for fabrication of the first membrane sensor (sensor 1) using phosphotungestate (PT) and dioctylphthalate (DOP) as cation exchanger and solvent mediator, respectively. β-cyclodextrin (β-CD)-based technique with PT as a fixed anionic site in PVC matrix was used for fabrication of the second membrane sensor (sensor 2). The proposed sensors showed fast, stable Nernstian responses of 54 and 56 mV/decade for sensors 1 and 2, respectively, across a relatively wide MD concentration range (1 × 10–4 to 1 × 10–1 mol/L and 5 × 10–5 to 1 × 10–1 mol/L for sensor 1 and 2, respectively) in the pH range of 5–7. Sensor 1 and sensor 2 can be used for three and two weeks, respectively without any measurable change in sensitivity. The suggested electrodes succeeded to determine intact MD in the presence of up to 10% of its degradation product and displayed good selectivity in presence of common inorganic and organic species.

2015
Zaazaa, H. E., E. S. Elzanfaly, A. T. Soudi, and M. Y. Salem, "Application of the ratio difference spectrophotometry to the determination of ibuprofen and famotidine in their combined dosage form; Comparison with previously published spectrophotometric methods", Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 143: Elsevier, pp. 251–255, 2015. Abstract
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Saad, A. S., A. K. Attia, M. S. Alaraki, and E. S. Elzanfaly, "Comparative study on the selectivity of various spectrophotometric techniques for the determination of binary mixture of fenbendazole and rafoxanide", Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 150: Elsevier, pp. 682–690, 2015. Abstract
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Zaazaa, H. E., E. S. Elzanfaly, A. T. Soudi, and M. Y. Salem, "Application of the ratio difference spectrophotometry to the determination of ibuprofen and famotidine in their combined dosage form; Comparison with previously published spectrophotometric methods", Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , vol. 143, pp. 251–255, 2015.
Saad, A. S., A. K. Attia, M. S. Alaraki, and E. S. Elzanfaly, "Comparative study on the selectivity of various spectrophotometric techniques for the determination of binary mixture of fenbendazole and rafoxanide", Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , vol. 150, pp. 682–690, 2015.
Elzanfaly, E. S., S. A. Hassan, M. Y. Salem, and B. A. El-Zeany, "Continuous Wavelet Transform, a powerful alternative to Derivative Spectrophotometry in analysis of binary and ternary mixtures: A comparative study", Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , vol. 151, pp. 945–955, 2015.