Chapter 19 - Bauhinia vahlii and antioxidant potential in diabetes
- Citation:
- Mahrous, E. A., and M. M. Nooh, "Chapter 19 - Bauhinia vahlii and antioxidant potential in diabetes", Diabetes (Second Edition): Academic Press, pp. 195 - 202, 2020.
Abstract:
Powerful antioxidants can delay progression of diabetes and protect vital organs for tissue damage caused by high concentration of free radicals and reactive oxygen species generated by a sustained state of hyperglycemia. Preliminary studies point to the positive effect of the alcoholic extract of Bauhinia vahlii leaves, a plant traditionally used for treatment of diabetes, in controlling oxidative stress associated with diabetes. Evidence indicates that B. vahlii exerts its effect through moderate antihyperglycemic effect and strong antioxidant activity. B. vahlii extract when given to diabetic Wister rats for 4 weeks was able to reduce fasting blood glucose and glycated hemoglobin by up to 43% and 37%, respectively, indicating moderate antihyperglycemic effect, which may be mediated by strong inhibition of α-glucosidase enzyme (IC50=30.7µg/mL). On the other hand, the antioxidant activity of B. vahlii allowed a full restoration of serum total antioxidant capacity, hepatic malonyldialdehyde, and reduced glutathione to their basal levels in normal nondiabetic animals after treatment with a daily dose of 300mg/kg b.w. Moreover, normal histological features and liver functions were observed in diabetic animals receiving the same dose of B. vahlii extract but not with the standard antidiabetic metformin.
Notes:
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