Gamal Soliman

Citation:

Soliman, G. A., and M. Abd El Raheim, "Antihyperglycemic, Antihyperlipidemic and Antioxidant effect of Atriplex farinosa and Atriplex nummularia in Streptozotocin-induced Diabetes in rats", Bull. Env. Pharmacol. Life Sci, vol. 4, pp. 10–18, 2015.

Abstract:

The present study was designed to investigate the antihyperglycemic effect of Atriplex farinosa (A. farinosa) and Atriplex nummularia (A. nummularia) extracts in streptozotocin (STZ)-diabetic rats. Glibenclamide was taken as the standard drug. Diabetes was induced in adult male albino rats, weighing 160-175 g, by administration of STZ (45 mg/kg of body weight) intraperitoneally. Diabetic rats showed an increase in levels of fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c) in addition to serum levels of triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL-C) and malondialdehyde (MDA) in their pancreas homogenates. They showed a decrease in levels of plasma insulin, hemoglobin (Hb), and serum level of high density lipoprotein (HDL-C)and activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and glutathione (GSH) in pancreas homogenates. Oral administration of A. farinosa and A. nummularia (200 and 400mg/kg) extracts and glibenclamide (0.6 mg/kg) decreased the FBG and elevated insulin levels after 4 and 8 weeks of treatment in STZ-diabetic rats in a dose-dependent manner. A meaningful reduction in the concentrations of HbA1c, TG, TC, LDL-C in serum and elevations in the activities of SOD, GPx, CAT and GSH in pancreas homogenates were observed in diabetic animals medicated with A. farinosa and A. nummularia extracts. Levels of HDL-Cin serum and MDA in pancreas homogenates were recovered significantly in A. farinosa and A. nummularia-medicated diabetic rats. Thus, our results show that A. farinosa and A. nummularia (200 and 400 mg/kg) possesses a promising antihyperglycemic effect that is comparable with glibenclamide.

Notes:

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