Gamal Soliman

Citation:

Yusufoglu, H. S., G. A. Soliman, R. F. Abdel-Rahman, M. S. Abdel-Kader, M. A. Ganaie, E. Bedir, S. B. Erel, and B. Öztürk, "Antihyperglycemic and Antihyperlipidemic Effects of Ferula assa-foetida and Ferula tenuissima Extracts in Diabetic Rats", Pakistan Journal of Biological Sciences, vol. 18, no. 7: Asian Network for Scientific Information (ANSINET), pp. 314, 2015.

Abstract:

The present study was carried to explore the potential antihyperglycemic and antihyperlipidemic activity of Ferula assa-foetida L. and Ferula tenuissima Hub-Mor & Pesmen extracts in streptozotocin (STZ) induced diabetic rats. Furthermore, phytochemical screening, in vitro antioxidant activity and acute toxicity study of both plants were performed. Both extracts showed considerable antioxidant potential in vitro. In diabetic rats, F. assa-foetida (200 and 400 mg/kg) and F. tenuissima (400 mg/kg) showed significant elevation in plasma insulin level, total hemoglobin (Hb) and decrease in Fasting Blood Glucose (FBG) and glycosylated hemoglobin (HbA1c) levels. Significant elevations in the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and level of reduced glutathione (GSH) in liver and pancreas homogenates were observed in diabetic animals following F. assa-foetida (200 and 400 mg kgG1) and F. tenuissima (400 mg kgG1) treatments. The antihyperlipidemic effect of F. assa-foetida extract was demonstrated by a significant reduction in plasma triglycerides (TG), Total Cholesterol (TC), Low Density Lipoprotein Cholesterol (LDL-C) and the increase of High Density Lipoprotein Cholesterol (HDL-C). Plasma activities of alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) and levels of Total Protein (TP) and bilirubin (BIL) in diabetic rats were recovered significantly after F. assa-foetida and F. tenuissima treatment in comparison with diabetic controls. The present data suggest that F. assa-foetida have both antihyperglycemic and antihyperlipidemic effects with enhancement of insulin-secreting activity.

Notes:

n/a