@article {160398, title = {Patterns of renal involvement in a cohort of patients with inflammatory bowel disease in Egypt.}, journal = {Acta gastro-enterologica Belgica}, volume = {81}, year = {2018}, month = {2018 Jul-Sep}, pages = {381-385}, abstract = {

BACKGROUND AND STUDY AIM: Renal complications are frequent extraintestinal manifestations in inflammatory bowel disease (IBD). We aimed in our study to describe the spectrum of renal affection in our IBD patients.

PATIENTS AND METHODS: This study is a retrospective analysis of renal biopsies done for IBD patients who developed renal diseases, at Cairo University Hospital, from June 2005 to Jan. 2016. Results : Among 896 IBD patients, 218 patients (24.3\%) developed renal affection. The onset of renal disease mandated renal biopsy at 5.6 {\textpm} 7.4 years after IBD diagnosis. Nephrotic range proteinuria was the most common indication for a renal biopsy [81 (37.15\%) patients]. Amyloidosis was the most common renal pathological diagnosis [56 patients (25.7\%)] followed by immunoglobulin A (IgA) nephropathy [35 patients (16.1\%)], focal segmental glome- rulosclerosis (FSGS) [32patients (14.7\%)], crescentic glomerulonephritis (CGN) [32 patients (14.7\%)], membranous nephropathy (MN) [18 patients (8.25\%)], minimal change disease [17 patients (7.7\%)], chronic interstitial nephritis (CIN) [10 patients (4.6\%)], acute tubular necrosis (ATN) [8 patients (3.7\%)], thrombotic microangiopathy (TMA) [6 patients (2.75\%)], and acute interstitial nephritis (AIN)[4 patients (1.8\%)]. Variable renal histopathology diagnoses did not correlate with age, duration of IBD diagnosis, or drugs used for IBD treatment. Crescentic GN was significantly correlating with ASCA, ANCA-p, and ANCA-c in serum.

CONCLUSION: Amyloidosis is a common renal pathological diagnosis in our patients, and is followed by IgA nephropathy, and FSGS.

}, issn = {1784-3227}, author = {Elaziz, M M A and A. Fayed} }