Maha, W., M H., Doaa A., & Shirin E. (2021).  Sexual Dysfunction and Psychopathological Variables Among Tramadol Abusers. Addictive Disorders & Their Treatment. 20,
Khoweiled, A., Gaafar Y., Kamel R., & Ayoub D. R. (2021).  Neurological soft signs correlation with symptom severity in borderline personality disorder.. Middle East Current Psychiatry.
Medhat, B. M., Abu-Zaid M. H., Dorgham D., NehalEl-Ghobashy, Afifi A. Y., El-Makawi S., et al. (2021).  Prevalence of Anti-Nuclear Antibodies and Anti-Phospholipid Antibodies in an Egyptian Cohort with Schizophrenia: A Case-Control Study.. Current rheumatology reviews. Abstract

BACKGROUND: Psychiatric disorders, including schizophrenia could herald other manifestation(s) of systemic lupus erythematosus (SLE) potentially hindering timely and optimal management. Moreover, schizophrenia is among the described 'extra-criteria' manifestations of anti-phospholipid syndrome (APS). Hence, screening schizophrenia patients for SLE and APS may pose diagnostic and therapeutic implications.

OBJECTIVES: Examine schizophrenia patients with no overt connective tissue disease(s) manifestation(s) for clinical and/or serologic evidence of SLE and/or APS.

METHODS: The study included 92 schizophrenia patients [61 (66.3%) males] and 100 age- and gender-matched healthy controls. Both groups were tested for anti-nuclear antibodies (ANAs), anti-double stranded deoxyribonucleic acid (anti-dsDNA) antibodies, complement 3 (C3) and C4, and criteria anti-phospholipid antibodies (aPL) [anticardiolipin Immunoglobulin (Ig) G and IgM, anti-beta-2-glycoprotein I IgG and IgM, and lupus anticoagulant (LAC)].

RESULTS: The patients' mean age and disease duration were 28.8 ± 8.1 and 5.7 ± 2.2 years, respectively. The prevalence of ANA positivity, height of titre, and pattern was comparable between patients and controls (p = 0.9, p = 0.8 and p = 0.1, respectively). Anti-dsDNA antibodies and hypocomplementemia were absent in both groups. A significantly higher frequency of positive LAC was observed among patients compared with controls (7.6 % vs. 1 %, p = 0.02), whereas other aPL were comparable between both groups. None of the patients or controls demonstrated clinically meaningful (medium or high) aPL titres.

CONCLUSION: In our study, schizophrenia was solely associated with LAC. Thus, in the absence of findings suggestive of SLE or APS, routine screening for both diseases is questionable.

Abdel Mawella, S. M., Hussein H. A., Zyada F., Abdelaal A., Ayoub D. R., & Naguy A. (2021).  Psychoendocrinology: arginine vasopressin and resilience in patients with major depressive disorder.. CNS spectrums. Abstract

BACKGROUND: There is a burgeoning body of evidence suggesting that arginine vasopressin (AVP) acts as a neuromodulator of the stress response. AVP stimulates the release of adrenocorticotropic hormone, synergistic to corticotropin-releasing hormone, which might explain AVP's role in resilience. Personal hardiness is the bedrock of resilience. Numerous studies have demonstrated elevated plasma levels of AVP in patients with major depressive disorder (MDD), suggesting an etiopathogenetic role as well as a novel therapeutic target.

OBJECTIVE: The aim of this study was to examine the relationship between AVP and resilience in patients with MDD and to determine AVP levels in serum of patients with MDD.

METHODS: Forty patients with MDD and 40 healthy control subjects were studied using the Dispositional Resilience (Hardiness) Scale by Barton, the Quality of Life Scale, the Social Readjustment Rating Scale, and the Beck Depression Inventory. Biochemical analysis of plasma levels of AVP, using the enzyme-linked immunosorbent assay (ELISA), was performed for all participants.

RESULTS: Levels of AVP were statistically significantly elevated in patients with MDD compared with healthy controls. Psychological hardiness was decreased in patients with MDD compared with healthy controls, a finding also statistically significant. There was a negative correlation between plasma AVP level and psychological hardiness.

CONCLUSION: AVP and psychological hardiness are negatively correlated, reflecting lower stress resilience. AVP levels are indeed higher in patients struggling with MDD.

El-Shinnawy, H., Sayed R. H., Khalil M. A., & Ayoub D. R. (2020).  Substance Dependence Comorbidity With Mental Disorders in Egyptian Young Adults. Addictive disorders and their treatment.
Moussa, S. S., Kamel R. M., Ayoub D. R., & elseesy S. W. (2016).  RPT O20. 3 Relational Play Therapy (RPT) from a Cross Cultural Perspective: An Egyptian Experience. IACAPAP Executive Committee.
AA, E. - B., AA M., DR A., & RM K. (2018).  Disordered eating behaviors among adolescent patients with patients with type I diabetes mellitus. Egyptian Journal of Psychiatry, 2018, Volume 39, Issue 3 [p. 127-132].. 39(3), 127-.