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Zoheir, N. M., M. S. Hamdy, M. M. Khorshied, N. N. Abulata, M. E. Sobky, A. M. Saleh, and H. M. Khairy, "Association of C46T genetic polymorphism of coagulation factor XII with deep venous thrombosis: a cohort study on Egyptian patients", Comparative Clinical Pathology, vol. 22, issue 2, pp. 203–207, 2013.
Zayed, S. A., N. M. Zahran, M. M. Khorshied, A. O. A. El-Aziz, O. Mahmoud, S. A. Morsy, H. I. Shousha, T. M. Elbaz, M. M. Nabeel, and A. R. K. Harb, "Genetic variations in death receptor domain 4 gene and the susceptibility to hepatitis C related hepatocellular carcinoma.", Journal of medical virology, vol. 91, issue 8, pp. 1537-1544, 2019. Abstract

BACKGROUND: Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality worldwide, particularly in Egypt. The role of apoptosis in tumorigenesis has been well-documented and resistance to apoptosis is a hallmark of cancer. Several studies discussed the association between death receptor 4 (DR4) genetic variants and HCC risk.

AIM: To study the possible link between DR4 gene polymorphisms and the susceptibility to HCC.

METHODS: Genotyping of DR4-C626G, -A683C, and DR4-A1322G single nucleotide polymorphisms (SNP) was determined by polymerase chain reaction assay for 100 de novo HCV-related HCC patients, 100 chronic hepatitis C-related liver cirrhosis patients, and 150 healthy controls.

RESULTS: DR4-A1322G polymorphic genotypes (AG and GG) were significantly higher in HCC and cirrhotic patients than controls. The AG genotype conferred two-fold increased risk of HCC (odds ratio [OR], 2.34; 95% confidence interval [CI], 1.56-3.51) and the risk increased to three-fold for the GG genotype (OR, 3.51; 95%CI, 2.33-5.28). The frequency of DR4-C626G and -A683C SNPs in HCC and cirrhotic patients were not significantly different from the controls. Combined genotype analysis showed that coinheritance of the polymorphic genotypes of DR4-C626G and -A1322G conferred nine-fold increased risk of HCC (OR, 9.34; 95%CI, 3.76-23.12). The risk increased to be 12-fold when DR4-A683C and -A1322G variants were coinherited (OR, 11.9; 95%CI, 4.82-29.39). Coexistence of the variant genotypes of the three SNPs conferred almost 10-fold increased risk of HCC (OR, 9.75; 95%CI, 1.86-51.19).

CONCLUSIONS: The G allele of DR4 -A1322G could be considered as a novel independent molecular predictor for HCV-related HCC in the Egyptian population.

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T, E., E. N, Gouda H, K. M, M. D, and O. D, "Prognostic implication of BAALC gene expression in de novo acute myeloid leukemia patients", Egyptian Journal of Internal Medicine, vol. Jan-April, 2009.
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hala Shiba, M. M. Khorshied, H. M. Gouda, S. A. Mousa, and M. K. El-Ghamarawy, "Prevalence of Hepatitis C among Egyptian Children with Sickle Cell Disease and the Role of IL28b Gene Polymorphisms in Spontaneous Viral Clearance.", Mediterr J Hematol Infect Dis, vol. 1;8(1):e2016007, 2016. il-28-hcv-scd-egypt.pdf
Shaheen, I., M. Khorshied, Rasha Abdel-Raouf, H. Gouda, D. Kamal, N. Abulata, R. Aboukhalil, and B. Meligy, "L-Selectin P213S and Integrin Alpha 2 C807T Genetic Polymorphisms in Pediatric Sickle Cell Disease Patients.", Journal of pediatric hematology/oncology, vol. 42, issue 8, pp. e707-e711, 2020. Abstract

Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy characterized by increased cellular adhesiveness. Vaso-occlusion (VOC) is the most prevalent disease complication of SCD that could be altered by genetic factors. L-Selectin and integrin alpha 2 (ITGA2) are 2 adhesion molecules linked to vasculopathy and inflammation. The current study aimed at detecting the prevalence of genetic variants of L-selectin and ITGA2 as possible molecular modulators and novel therapeutic targets in a cohort of pediatric SCD patients. Genotyping was performed by polymerase chain reaction restriction fragment length polymorphism technique for 100 SCD patients and 100 age and gender-matched unrelated healthy controls. The homomutant genotype of ITGA2 C807T was significantly higher in SCD patients compared with controls (P=0.001) and confirmed almost a 3-fold increased risk of moderate and severe attacks of VOC. There are significant adverse effects caused by the polymorphisms of ITGA2, and hence Egyptian SCD patients could benefit from the targeted therapies specifically against ITGA2 to ameliorate the severe course of the disease and improve the quality of life. However, further studies of genotypes and expression levels of these adhesion molecules during the attacks of VOC are recommended.

Shaheen, H. A., M. Khorshied, M. A. El-Sayed, M. A., and M. A. Taha, "Post Stroke Infection Frequency and Immunosuppression Contribution", Egyptian Journal of Neurology, Psychiatry & Neurosurgery, vol. 49, issue 3, pp. 239-244, 2012.
Shaarawy, E., R. A. N. I. A. A. B. D. EL-HAY, nesrine samir, and M. Khorshied, "Lack of Association between Interleukin-1 β Gene Polymorphisms and Alopecia Areata; A Case-Control Study ", Med. J. Cairo Univ., vol. 84, issue 2, pp. 197-201, 2016. il1b-vitiligo-2016-ours.pdf
Saleh, N. F., N. Nabil, D. A. Bassiouny, and M. M. Khorshied, "Tumor necrosis factor α promotor polymorphism and nonsegmental vitiligo: a molecular susceptibility marker in Egyptian women ", Journal of The Egyptian Women's Dermatologic Society, vol. 11, issue 2, pp. 109-112, 2014.
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Rahman, H. A. A., M. M. Khorshied, O. M. Khorshid, and S. M. Mahgoub, "Toll-like receptor 2 and 9 genetic polymorphisms and the susceptibility to B cell Non-Hodgkin Lymphoma in Egypt.", Ann Hematol. , vol. 93, issue 11, pp. 1859-65, 2014.
Raafat, I. I., N. A. Azab, M. M. Khorshied, M. H. Yacoub, and L. A. Samy, "Signal transducer and activator of transcription 4 (STAT4) G/T gene polymorphism in Egyptian systemic lupus erythematosus female patients ", The Egyptian Rheumatologist , vol. 37, pp. 75-80, 2015.
R, Y., A. - H. MRE, K. M, K. M, and F. A, "Effect of polymorphisms in IL-12B p40, IL-17A and IL-23 A/G genes on the response of psoriatic patients to narrowband UVB", Photodermatol Photoimmunol Photomed. , vol. 34, issue 5, pp. 347-349, 2018.
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N., E. S., S. E. D. M., L. N., S. N., K. M., and E. M. L., "Expression of vascular endothelial growth factor and its receptors FLT-1 and KDR in acute leukemia: Clinical relevance and future prospects. ", The Medical Journal of Cairo University, vol. 75, issue 2, pp. 43–50, 2007.
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Mostafa, A., M. Khorshied, H. Gouda, and M. Sroor, "Expresasion and clinical implication of Cyclic adenosine monophosphate response element binding protein (CREB) in de novo AML. ", Egypt. J. Lab. Med. , vol. 20, 2008.
Mostafa, W. Z., M. F. Hussein, E. F. Aly, M. M. Khorshied, E. B. Eweis, A. M. Abdelmeged, M. S. El-Hawary, and V. G. Hafez, "Circulating T regulatory cells in patients with psoriasis with and without atherosclerosis: A pilot comparative study before and after photochemotherapy.", Photodermatology, photoimmunology & photomedicine, 2021.
M., E. K., E. F. T., E. S. G., T. A., A. M., A. F. H., E. K. O., K. M., and A. R. S. Gouda H., "Effect of Uremia on polymorphnuclear leucocytes activity and apoptosis", The Egyptian Journal of internal Medicine, vol. 19, issue 1, pp. 57-69, 2007.
M, E. L. - G. N., K. MM, Gouda H, S. IA, A. K. RE, S. M. Y, and A. L. - B. TN, "The Clinical Relevance of Cyclin A1 over Expression in Acute Myeloid Leukemia", The Egyptian Journal of Haematology , vol. 33, issue 4, pp. 362-369, 2008.
M, K., Gouda H, M. I. A, S. M, and A. L. - B. TN, "Expression and Clinical Implication of ZAP-70 in Acute Lymphoblastic Leukemia ", Journal of Medical Science , vol. 8, issue 5, pp. 461-468, 2008.
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Khorshied MM, Said WA, S. H. A., "Nucleophosmin gene mutation in acute myeloid leukemia patients.", Saudi Med J. , vol. 31, issue 5, pp. 582-4., 2010.
Khorshied, M. M., A. A. Zayed, and M. F. Hussein, "Inducible nitric oxide synthase promoter polymorphism: a molecular susceptibility marker for vitiligo in Egyptians.", Int J Dermatol. , vol. 54(6), pp. 675-9, 2015.
Khorshied, M. M., M. El-Ghamrawy, M. E. Yassa, A. M. S. Tosson, and M. A. El-Hady, "Association between BCL11A, HSB1L-MYB, and XmnI γG-158 (C/T) gene polymorphism and hemoglobin F level in Egyptian sickle cell disease patients", Annals of Hematology, vol. 99, issue 10, pp. 2279-2288, 2020.
Khorshied, M. M., W. A. Said, and H. M. Shaaban, "Clinical implication of nucleophosmin gene mutation and Flt-3 internal tandem duplication in a cohort of Egyptian AML patients", Comparative Clinical Pathology, vol. 22, issue 3, pp. 497–506, 2013.