Publications

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2013
Khorshied, M. M., W. A. Said, and H. M. Shaaban, "Clinical implication of nucleophosmin gene mutation and Flt-3 internal tandem duplication in a cohort of Egyptian AML patients", Comparative Clinical Pathology, vol. 22, issue 3, pp. 497–506, 2013.
A.M.Khattab, R., M. M.A.Khorshied, S. S. A. Shafy, M. S. E. Ansary, and S. M. Moukhtar., "In vitro transdifferentiation of umbilical cord stem cells into cardiac myocytes: Role of growth factors", The Egyptian Journal of Critical Care Medicine , vol. 1, pp. 43–50, 2013.
Deen, M. A. K. E., M. M. Khorshied, Z. A. E. Sadani, Y. M. Amrousy, and N. M. Galal, "Mannose-binding lectin (MBL2) gene polymorphism in sickle cell anemia: an Egyptian study", Comparative Clinical Pathology , vol. 22, issue 3, pp. 387-394, 2013.
Hamdy, M. S. E. D., H. M. Gouda, I. A. M. Shaheen, M. M. Khorshied, and R. H. Tomerak, "Prevalence of factor V Leiden (G1619A) and prothrombin gene (G20210A) mutation in Egyptian children with sickle cell disease", Comparative Clinical Pathology , vol. 22, issue 4, pp. 697-702, 2013.
BM, E. - Z., A. OA, Z. NS, A. - R. HM, B. DA, and K. MM, "PTPN22 gene polymorphism in Egyptian alopecia areata patients and its impact on response to diphencyprone immunotherapy.", Gene, vol. Epub ahead of print, 2013. Abstract

PTPN22 1858C>T gene polymorphism has been associated with several autoimmune disorders including alopecia areata. The aim of the current study was to investigate the effect of the inherited genetic polymorphism 1858C>T of PTPN22 gene on the predisposition to severe forms of alopecia areata and its effect on the response to DPC treatment. To achieve our aim, PTPN22 1858C>T genotyping was performed by PCR-based restricted fragment length polymorphism (PCR-RFLP) analysis. The study included 103 Egyptian patients with extensive alopecia areata treated by DPC. Hundred healthy age and sex matched blood donors were included in the current study as a control group. Results of genotyping showed that PTPN22 CT and TT mutant genotypes were significantly higher in AA patients compared to controls and conferred increase risk of AA (OR = 2.601, 95% CI = 1.081–6.255). Statistical comparison between AA patients with wild and mutant genotypes revealed that the duration of the illness was significantly longer in those harboring the mutant genotypes. Moreover, the association of other autoimmune diseases as atopy and diabetes mellitus was higher in patients with mutant genotypes. Furthermore, PTPN22 1858C>T genetic polymorphism did not affect the patients' response to DPC immunotherapy.

2014
Gouda, H. M., M. M. Khorshied, I. A. Shaheen, M. E. H. Sissy, and M. A. Mohsen, "Association between matrix metalloproteinase 2 (MMP2) promoter polymorphisms and the susceptibility to non-Hodgkin's lymphoma in Egyptians.", Ann Hematol. , vol. 93, issue 8, pp. 1313-8, 2014.
Farawela, H. M., M. M. Khorshied, H. M. Zawam, N. M. Kassem, and H. A. Kassem, "The clinical relevance and prognostic significance of adenosine triphosphate ATP-binding cassette (ABCB5) and multidrug resistance (MDR1) genes expression in acute leukemia: an Egyptian study.", J Cancer Res Clin Oncol. , vol. 140, issue 8, pp. 1323-30, 2014.
Khorshied, M. M., I. A. Shaheen, R. A. E. Khalil, and R. E. Sheir, "Methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms in chronic myeloid leukemia: an Egyptian study.", Med Oncol, vol. 31, issue 1, pp. 794, 2014.
Rahman, H. A. A., M. M. Khorshied, O. M. Khorshid, and S. M. Mahgoub, "Toll-like receptor 2 and 9 genetic polymorphisms and the susceptibility to B cell Non-Hodgkin Lymphoma in Egypt.", Ann Hematol. , vol. 93, issue 11, pp. 1859-65, 2014.
Saleh, N. F., N. Nabil, D. A. Bassiouny, and M. M. Khorshied, "Tumor necrosis factor α promotor polymorphism and nonsegmental vitiligo: a molecular susceptibility marker in Egyptian women ", Journal of The Egyptian Women's Dermatologic Society, vol. 11, issue 2, pp. 109-112, 2014.
2015
Khorshied, M. M., A. A. Zayed, and M. F. Hussein, "Inducible nitric oxide synthase promoter polymorphism: a molecular susceptibility marker for vitiligo in Egyptians.", Int J Dermatol. , vol. 54(6), pp. 675-9, 2015.
Raafat, I. I., N. A. Azab, M. M. Khorshied, M. H. Yacoub, and L. A. Samy, "Signal transducer and activator of transcription 4 (STAT4) G/T gene polymorphism in Egyptian systemic lupus erythematosus female patients ", The Egyptian Rheumatologist , vol. 37, pp. 75-80, 2015.
2016
Khorshied, M. M., and H. M. Gouda, "Diagnostic values of CD64, C-reactive protein and procalcitonin in ventilator-associated pneumonia in adult trauma patients: a pilot study.", Clin Chem Lab Med., vol. pii: /j/cclm.ahead-of-print/cclm-2015-0656/cclm-2015-0656.xml. doi: 10.1515/cclm-2015-0656. [Epub ahead of print], 2016.
Shaarawy, E., R. A. N. I. A. A. B. D. EL-HAY, nesrine samir, and M. Khorshied, "Lack of Association between Interleukin-1 β Gene Polymorphisms and Alopecia Areata; A Case-Control Study ", Med. J. Cairo Univ., vol. 84, issue 2, pp. 197-201, 2016. il1b-vitiligo-2016-ours.pdf
hala Shiba, M. M. Khorshied, H. M. Gouda, S. A. Mousa, and M. K. El-Ghamarawy, "Prevalence of Hepatitis C among Egyptian Children with Sickle Cell Disease and the Role of IL28b Gene Polymorphisms in Spontaneous Viral Clearance.", Mediterr J Hematol Infect Dis, vol. 1;8(1):e2016007, 2016. il-28-hcv-scd-egypt.pdf
2017
BM, E. - Z., E. S, B. D, Z. NS, Z. NS, S. R, S. MA, A. - H. D, G. H, H. R, et al., "Effect of Procedural-Related Variables on Melanocyte-Keratinocyte Suspension Transplantation in Nonsegmental Stable Vitiligo: A Clinical and Immunocytochemical Study.", Dermatol Surg., vol. 43, issue 2, pp. 226-235, 2017.
B, E. - Z., B. D, H. R, G. H, S. S, K. MM, and S. MA, "Rituximab treatment in pemphigus vulgaris: effect on circulating Tregs.", Arch Dermatol Res. 2017, 2017.
2018
Khorshied, M., O. Ibrahim, A. Gad, and M. El-Ghamrawy, "The effect of interleukin-1β and interleukin-6 genetic polymorphisms on sickle cell disease course in childhood: an Egyptian study", Archives of Medical Science-Civilization Diseases , vol. 3, issue 1, pp. 57-63, 2018.
R, Y., A. - H. MRE, K. M, K. M, and F. A, "Effect of polymorphisms in IL-12B p40, IL-17A and IL-23 A/G genes on the response of psoriatic patients to narrowband UVB", Photodermatol Photoimmunol Photomed. , vol. 34, issue 5, pp. 347-349, 2018.
Ghobrial, E. E., H. M. Marzouk, M. M. Khorshied, and M. G. Sayed, "Level of Interleukin 37 (IL-37) in Children with Systemic Lupus Erythematosus and Its Correlation with Disease Activity", Iranian Journal of Pediatrics 28 , vol. 28, issue 1, 2018.