Association Between {CagA} {EPIYA} Motifs with Diverse Gastroduodenal Outcomes in Egyptian Patients Infected with Helicobacter pylori
- Citation:
- Elhossary, W., R. Fouad, W. F. Fathallah, doaa ghaith, and M. Saif Elnasr, "Association Between {CagA} {EPIYA} Motifs with Diverse Gastroduodenal Outcomes in Egyptian Patients Infected with Helicobacter pylori", Global Gastroenterology, vol. 2, no. 1, 2024.
Abstract:
Abstract Background and Aim: Helicobacter pylori {CagA} gene is a major virulence factor that undergoes tyrosine phosphorylation in a region holding differing numbers of repeat sequences ({EPIYAs}) resulting in modulation of the inflammatory response. The aim of this cross-sectional study is to determine the correlation between {CagA} {EPIYA} motifs with diverse gastroduodenal outcomes. Methods: Gastric biopsies were collected from 54 Egyptian patients (11 patients with {PUD} and 43 chronic non atrophic gastritis). Molecular detection of H. pylori, {CagA} gene with determination of the {EPIYA} motifs in {CagA} positive cases were done. Results: Out of the 54 H. pylori positive cases, {CagA} gene was detected in 31 patients. {EPIYA}-{ABC} was the most presented pattern in 22 cases (71 %) and the least common pattern was {EPIYA}-{ABCCC}, which was positive only in one case (3.2%). Both {EPIYA}-{AB} and {EPIYA}-{ABCC} were presented in 4 cases for each (12.9% for each). Conclusion: There was a significant statistical correlation between the presence of {CagA} gene and both {PUD} and {GU}. Furthermore, the structure of the variable region of the {CagA} gene in Egyptian strains was Western type with a variable number of {EPIYA}‑C.
Notes:
Publisher: Egyptian Foundation for Helicobacter and Microbiota ({EFHM}).