@article {Elhossary2024,
	title = {Association Between {CagA} {EPIYA} Motifs with Diverse Gastroduodenal Outcomes in Egyptian Patients Infected with Helicobacter pylori},
	journal = {Global Gastroenterology},
	volume = {2},
	number = {1},
	year = {2024},
	note = {<p>Publisher: Egyptian Foundation for Helicobacter and Microbiota ({EFHM}).</p>
},
	abstract = {<p>Abstract Background and Aim: Helicobacter pylori {CagA} gene is a major virulence factor that undergoes tyrosine phosphorylation in a region holding differing numbers of repeat sequences ({EPIYAs}) resulting in modulation of the inflammatory response. The aim of this cross-sectional study is to determine the correlation between {CagA} {EPIYA} motifs with diverse gastroduodenal outcomes. Methods: Gastric biopsies were collected from 54 Egyptian patients (11 patients with {PUD} and 43 chronic non atrophic gastritis). Molecular detection of H. pylori, {CagA} gene with determination of the {EPIYA} motifs in {CagA} positive cases were done. Results: Out of the 54 H. pylori positive cases, {CagA} gene was detected in 31 patients. {EPIYA}-{ABC} was the most presented pattern in 22 cases (71 \%) and the least common pattern was {EPIYA}-{ABCCC}, which was positive only in one case (3.2\%). Both {EPIYA}-{AB} and {EPIYA}-{ABCC} were presented in 4 cases for each (12.9\% for each). Conclusion: There was a significant statistical correlation between the presence of {CagA} gene and both {PUD} and {GU}. Furthermore, the structure of the variable region of the {CagA} gene in Egyptian strains was Western type with a variable number of {EPIYA}-C.</p>
},
	issn = {2974-4245},
	doi = {10.21608/gg.2024.252140.1024},
	url = {https://gg.journals.ekb.eg/article_362460.html},
	author = {Elhossary, Walied and Fouad, Rabab and Fathallah, Waleed Fouad and doaa ghaith and Saif Elnasr, Mohamed}
}
