Fouad, M. M., N. H. Zawilla, A. A. Abdelsamie, M. Manawil, R. S. A. Shehata, R. S. Mohammed, E. M. Khalifa, M. A. Ramadan, and B. H. Mourad, "Successful Management of Severe Unresponsive Snake Bite Envenomation Using Plasmapheresis and Corticosteroid at Egyptian National Environmental and Clinical Toxicology Research Center: A Case Report.", Wilderness & environmental medicine, vol. 35, issue 1, pp. 82-87, 2024. Abstract

Snakebite is a significant public health issue in which venom-induced consumption coagulopathy is a common and serious complication that results from the activation of the coagulation pathway by snake toxins. We report a male patient, 56 y old, who was thought to have been bitten by a snake on his left foot. He was transported to a nearby hospital where he received analgesics and 3 snake polyvalent antivenom vials, and then he was transported to our hospital after 12 h. He presented with 2 small puncture wounds, pain, blistering, and edema of the left foot. On the 2nd day, the patient developed gingival bleeding and hematuria. Laboratory investigations upon admission revealed prothrombin time (PT) of more than 3 min, prothrombin concentration (PC) of less than 2.5%, and an international normalized ratio (INR) of 23.43. Further investigation of urine showed more than 100 RBCs. Despite receiving 16 packs of plasma and 40 snake polyvalent antivenom vials manufactured by VACSERA over 3 days, hemoglobin concentration and platelet count decreased with the appearance of jaundice, lactate dehydrogenase was 520, and reticulocytes were 3.5%. PT was more than 300 s, and INR was still over range. Plasmapheresis and corticosteroids were provided, which improved the patient's general condition, PT, PC, and INR, and the patient was discharged after 6 days of hospital stay. This case report indicated that plasmapheresis and corticosteroids were clinically efficient approaches in the management of snake envenomation unresponsive to antivenom.

Ramadan, M. A., and B. H. Mourad, "IMPACT OF CLIMATE CHANGE ON OCCUPATIONAL HEALTH AND ITS POSSIBLE PREVENTIVE STRATEGIES (REVIEW ARTICLE) ", Egyptian Journal of Occupational Medicine, vol. 46, issue 3, pp. 47-62, 2022.
Mourad, B. H., "BIOMONITORING IN OCCUPATIONAL MEDICINE (REVIEW ARTICLE)", Egyptian Journal of Occupational Medicine, vol. 48, issue 1, pp. 47-61, 2024.
Shaker, D. A. H., R. A. Kader, S. T. Salem, and B. H. Mourad, "PULMONARY FUNCTIONS AND IMMUNOLOGICAL RESPONSE AMONG HEALTH CARE WORKERS RECOVERED FROM COVID-19 INFECTION COMPARED TO THEIR COUNTERPARTS WITHOUT PREVIOUS INFECTIO", Egyptian Journal of Occupational Medicine, vol. 47, issue 1, pp. 79-95, 2023.
Mourad, B. H., and H. S. Teleb, "ALTERATION OF THE IMMUNE FUNCTIONS AMONG WORKERS OF SECONDARY ALUMINUM SMELTING", Egyptian Journal of Occupational Medicine, vol. 47, issue 1, pp. 19-34, 2023.
Mourad, B. H., and I. F. Gaballah, "Studying the Association Between Occupational Stress and Urinary Levels of Oxidative Stress Biomarkers (8-OHdG and Biopyrrins) in Brickfield Workers.", Journal of occupational and environmental medicine, vol. 65, issue 1, pp. 60-66, 2023. Abstract

OBJECTIVES: The aims of the study are to measure the prevalence and level of occupational stress (OS) and to explore its association with oxidative stress among some brickfield workers.

METHODS: Eighty-six brickfield workers and 90 administrative controls were assessed using the Arabic validated version of the Occupational Stress Index. The urinary levels of oxidative biomarkers; 8-hydroxy-2'-deoxyguanosine and biopyrrins were also measured.

RESULTS: The prevalence of moderate and severe OS in addition to the urinary levels of both oxidative biomarkers was significantly higher among the brickfield workers compared with their controls. Both biomarkers levels were significantly and positively correlated with scores of Occupational Stress Index, duration of employment, and with each other. The receiver operating characteristic analysis showed significant specificity and sensitivity of both biomarkers for determining the level of OS.

CONCLUSIONS: A significant association between occupational and oxidative stresses was detected in brickfield workers.

Mourad, B. H., and G. H. El-Sherif, "Exploring the Link Between the Serum/Blood Levels of Heavy Metals (Pb, As, Cd, and Cu) and 2 Novel Biomarkers of Cardiovascular Stress (Growth Differentiation Factor 15 and Soluble Suppression of Tumorigenicity 2) in Copper Smelter Workers.", Journal of occupational and environmental medicine, vol. 64, issue 11, pp. 976-984, 2022. Abstract

OBJECTIVE: Studying the association between the occupational exposure to Pb, As, Cd, and Cu with the serum levels of 2 novel biomarkers of cardiovascular stress; growth differentiation factor 15 and soluble suppression of tumorigenicity 2, in some Egyptian Cu smelter workers.

METHODS: Forty-one exposed workers and 41 administrative controls were clinically evaluated. Serum/blood levels of heavy metals and biomarkers were measured for both groups.

RESULTS: The smelter workers showed significantly elevated levels of heavy metals and biomarkers compared with controls. The elevated serum levels of both biomarkers were significantly and positively correlated with each other, the levels of heavy metals, and the duration of employment of the exposed workers.

CONCLUSIONS: There was a significant association between the levels of heavy metals and both biomarkers among the smelter workers. Further prospective studies should be performed.

Mourad, B. H., "DETECTION OF INSULIN RESISTANCE AND RISK OF TYPE 2 DIABETES MELLITUS AMONG BISPHENOL A EXPOSED WORKERS.", Egyptian Journal of Occupational Medicine, vol. 45, issue 2, pp. 1-16, 2021.
Mourad, B. H., and Y. A. Ashour, "Demonstration of Subclinical Early Nephrotoxicity Induced by Occupational Exposure to Silica among Workers in Pottery Industry", International Journal of Occupational and Environmental medicine, vol. 11, issue 2, pp. 85-94, 2020.