El Zawahry, B., N. Zaki, V. Hafez, R. Abdel Hay, and A. Fahim, "Efficacy and safety of fractional carbon dioxide laser for treatment of unwanted facial freckles in phototypes II-IV: a pilot study", Lasers Med Sci., vol. 29, issue 6, pp. 1937-1942, 2014.
El-Zawahry, B. M., O. A. Azzam, N. S. Zaki, H. M. Abdel-Raheem, D. A. Bassiouny, and M. M. Kh, "PTPN22 gene polymorphism in Egyptian alopecia areata patients and its impact on response to diphencyprone immunotherap", Gene, vol. 523, pp. 147–151, 2013. Abstract

PTPN221858C>Tgenepolymorphismhasbeenassociatedwithseveralautoimmunedisordersincludingalopecia areata.Theaimofthecurrentstudywastoinvestigatetheeffectoftheinheritedgeneticpolymorphism1858C>T ofPTPN22geneonthepredispositiontosevereformsofalopeciaareataanditseffectontheresponsetoDPCtreat- ment.Toachieveouraim,PTPN221858C>TgenotypingwasperformedbyPCR-basedrestrictedfragmentlength polymorphism (PCR-RFLP) analysis. The study included 103 Egyptian patients with extensive alopecia areata treatedbyDPC.Hundredhealthyageandsexmatchedblooddonorswereincludedinthecurrentstudyasacon- trol group. Results of genotyping showed that PTPN22 CT and TTmutant genotypesweresignificantlyhigher in AApatientscomparedtocontrolsandconferredincreaseriskofAA(OR = 2.601,95%CI = 1.081–6.255).Statis- tical comparison between AA patients with wild and mutant genotypes revealed that the duration of the illness wassignificantlylongerinthoseharboringthemutantgenotypes.Moreover,theassociationofotherautoimmune diseases as atopy and diabetes mellitus was higher in patients with mutant genotypes. Furthermore, PTPN22 1858C>T genetic polymorphism did not affectthe patients' response to DPC immunotherapy

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