Ayman Goudah Abouzeid
Professor of Pharmacology
Cairo University, Faculty of Veterinary Medicine, Pharmacology Department, Giza 12211 (email)
A Goudah
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Phone: +1-(514)-449-1592
E-mail:aymangouda@yahoo.com, aymangouda@hotmail.com
https://www.scopus.com/authid/detail.uri?authorId=6602935088
https://www.ncbi.nlm.nih.gov/pubmed/?term=GOUDAH+A
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PROFILE
Pharmacologist with 20 years of pharmacokinetic (ADME), pharmacodynamics (PD), bioavailability (BA), bioequivalence (BE) experience in pharmaceutical research and development and over 15 years of experience in Toxicology, molecular genetics and screening the pharmacological action of new compounds looking for a challenging position studies that I have acquired over the past few years at Cairo University and The Ohio State University. Experienced with working with interdisciplinary, international, multiple site teams to deliver results. Well versed in the critical thinking, decision making, creative problem solving, and computer skills required for scientific research. Enthusiastic interest for acquiring and applying new knowledge and expertise to overcome challenges. Excellent organizational, interpersonal, and communication skills. Awareness of practices required in industrial research to protect intellectual property rights. I Have many publications in excellent journals and also have extensive teaching experience in general and advanced Pharmacology classes and laboratories, for under-graduate, graduate and post-graduate level.
Teaching HLSC 4310U ‐Altered Physiology IV‐Pharmacological Interactions. How pharmacotherapy influences physiology, and how side effects and drug interactions related to pharmacotherapy may also influence the course of complex chronic conditions.
An overview of the mechanism of action of drugs and toxins that affect the human body in normal and altered states.
I'm not only work with veterinary practices that deliver veterinary care directly to large animal (beef cattle, Dairy cattle) farmer, but also with the broader animal health industry, including manufacturers and distributors of animal pharmaceuticals and other medical products, as well as providers of business products and services designed for veterinarians and veterinary practices.
I was a member of the research team for several major studies of the veterinary profession (Pfizer Animal Health, Egypt, Medical Professions For Veterinary Products & Fodders Additions Company (MUVCO, Egypt) and Newpharma research center AB (Sweden) (Pharmaswede, Egypt), as well as several studies involving aspects of veterinary practice operations prepared on the behalf of companies in the animal health industry.
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● Carried out independent and collaborative research projects.
- Pharmacokinetics and Pharmacodynamics of different anti-microbial agents in different animal species.
- Bioavailability (BA), bioequivalence study (BE).
- Pharmacokinetics of endectocide (ivermectin alone and a novel formulation of ivermectin and rafoxanide) in calves and sheep.
- Drug residues of anti-microbial agents in tissues
- Biotransformation of new drugs
- Screening of new chemical compounds using animal techniques
- Screening the toxicological effects of new compounds.
- Tested the biological activity of different chemical compounds.
- Toxicological study.
● Worked on a project titled “Development of new pharmaceutical preparations with insecticidal activity from Egyptian plants” funded from Cairo University, Giza, Egypt.
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy. .
Participated in all laboratory and group functions, gaining experience in Analytical work and related areas.
Contributed to an NIH funded research projects.
Worked on two projects “Synthesis and evaluation of amino acid prodrugs of 3-Carboranyl Thymidine Analogues (3-CTAs) for Boron Neutron Capture Therapy (BNCT)” and “Synthesis of N5 and N5-2OH Phosphates”.
My primary focus was to conduct analytical studies for the synthesized compounds and calculate the half-lives for the synthesized compounds in Phosphate Buffer Saline (PBS), Bovine Serum and Bovine Cerebrospinal Fluid (CSF), also investigate the water solubility’s of the amino acid ester pro-drugs, evaluated in Phosphate Buffered Saline at pH 5, pH 6 and pH 7.4.
Pharmacology Department, College of Medicine
Participated in all laboratory and group functions, gaining experience in pharmacogenomics and related areas. Specifically, contributed to a research project focusing on the genetics of cholesterol ester transfer protein (CETP), an important shuttle for cholesterol form HDL to LDL. CETP has long been considered a key factor in risk for coronary artery disease, but the genetics of this complex gene have remained enigmatic. I completed a series of genotyping assays in a cohort of 1,500 coronary artery disease subjects, contributing substantively to this research project. The results have helped determine the key defect in CETP, and regulatory variants as potential risk factors for CAD, or response to lipid lowering drugs.
Facultad de Ciencias Veterinarias, Universidad Nacional del Centro, Campus Universitario, Tandil,
Participated in all laboratory and group functions, gaining experience in pharmacokinetics and related areas. Specifically, contributed to a research project focusing on the pharmacokinetics of anthelmintic medication (Albendazole Sulphoxide) in sheep.
Cairo University, Egypt, 1996-1999
Cairo University, Egypt, 1993- 1996
Cairo University, Egypt, 1986-1992
ANALYTICALANDR&D SKILLS
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Working under GLP Conditions.
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Excellent communication skills (written and verbal in English & Arabic) and Basic French.
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- Provide scientific and strategic leadership on new approaches to diagnostic imaging agent development in line with current guidance.
- Work with other functions to produce fit for purpose documentation.
- Communicate strategy/progress updates to project team and key stakeholders.
- Attend external site visits for project meetings and to monitor key phases of studies.
- Provide leadership, develop research strategy, and coordinate pharmacology activities as the Pharmacology representative to drug discovery teams.
- Design and interpret pharmacology studies to evaluate the activities of drug candidates, investigate their mechanisms of action, and explore novel therapeutic hypotheses.
- Be responsible for communication between the drug discovery team and the pharmacology function and between R&D Leadership and drug the discovery team.
- Formulate data-driven decisions by designing and executing experiments that inform thinking and critical decision making for program teams.
- Focus on developing and executing disease-relevant, in vitro and in vivo experiments to evaluate the efficacy and mode of action of novel drug candidates.
- Prepare, review and deliver scientific presentations for internal/external audience.
- Proven record of scientific achievements demonstrated by publications and presentations.
- Knowledge in pharmacokinetics and pharmacodynamics concepts and data analysis is a plus.
- Independently analyze, interpret data, and present data in internal (lab meetings, journal clubs; leadership meetings) and external settings (collaborator meetings, conferences).
- Maintain accurate, complete, and timely data in laboratory notebooks.
- Strong publication record in peer-reviewed journals.
♦ Perform literature, data searches/reviews as necessary to obtain background information for review and preparation of study-related documents.
♦ (e.g., abstract, journal and review article), poster board construction and presentation.
♦ Microsoft Office package (Microsoft Word, Excel, Access, Publisher, PowerPoint, and Outlook).
♦ Internet and e-mail.
♦ Scientific data retrieval from various Internet portals like Google, Sciencedirect, Pubmed, , Scirus…etc
♦ Graphics (Adobe Photoshop, Adobe Illustrator and CorelDraw), EndNote.
♦ Prism, GraphPad InStat, Micocal Origin, SPSS.
♦ PK modeling software (WinNonlin, R Strip, PK Solutions).
♦ Toxicological Study TK.
♦ PK Modeling (Physiologically Based Pharmacokinetic (PBPK) modeling, Pharmacokinetic/Pharmacodynamic (PK/PD) Model, bioavailability, bioequivalence, Compartmental Pharmacokinetic Models, Individual and Population PK.
♦Working under GLP Conditions.
♦Basic Lab Skills
♦Literature screening
♦Develop analytical HPLC techniques for drug analysis, sample extraction.
♦Molecular/biochemical assays:DNAand RNA extraction, agarose and polyacrylamide gel electrophoresis, gel extractions,DNAsequencing analysis, standard and real-time RT-PCRandDNAmethylation studies, epigenetics, prepare solutions and reagents, detailed recording of events, organized and thorough data analysis
♦Expertise in animals (rodents, Rabbits……etc) in performing pharmacological evaluation of new therapeutic candidates including surgical and anesthesia methods as well as other routine animal handling and procedural skills (drug administration (e.g. Oral, i.p., s.c., i.v.), locomotor activity, drinking suppression, measurements of anti-nociception (e.g. hot plate tail flick), Anti-inflammatory, diuretic activity, anti-gastric ulcer, anti-pyretic, anticonvulsant ….etc).
♦Perform clinical sign assessment of well-being (weight monitoring, visual inspection……etc).
♦Collection of biological samples:
- Blood and/or biological fluids collection.
- Organ harvesting (with or without perfusion).
♦Set up a study and follow the experimental protocols requirements. Perform technical activities and collect any relevant data sets. Follow Standard Operating Procedures (SOP) and Good Laboratory Practices (GLP) regulations in order to maintain the high quality standards of the enterprise.
Dealing with (Rodents (Rats & Mice), Dogs, Pigs, Rabbits, Guinea pigs, Monkey……etc). Blood sampling, Drug Administration, Clinical Observation, Body weight measurement, food/water intake, Animal Husbandry….etc.
♦Design and conduct of bioavailability and bioequivalence studies.
♦Working knowledge of pharmacokinetic and statistical software.
♦ Bioavailability (BA), bioequivalence study (BE).
♦ Toxicological study.
(Last updated: Wed, 2020-12-30 00:19)