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2022
Ebrahim, H. A., S. S. Kamar, M. A. Haidara, N. A. S. Latif, M. Abd Ellatif, A. M. Shams Eldeen, B. Al-Ani, and A. F. Dawood, "Association of resveratrol with the suppression of TNF-α/NF-kB/iNOS/HIF-1α axis-mediated fibrosis and systemic hypertension in thioacetamide-induced liver injury.", Naunyn-Schmiedeberg's archives of pharmacology, 2022. Abstract

Chronic liver injury can lead to hepatic failure and the only available method of treatment would be liver transplantation. The link between inflammation (TNF-α), nuclear factor-kappa B (NF-kB), nitrosative stress (iNOS) and hypoxia-inducible factor-1α (HIF-1α) in thioacetamide (TAA) induced liver fibrosis, and hypertension with and without the incorporation of the anti-inflammatory and antioxidant resveratrol (RES) has not been investigated before. Consequently, we injected rats with either 200 mg/kg TAA for 8 weeks starting at week 2 (model group) or pretreated them before TAA injections with RES (20 mg/kg) for 2 weeks and continued them on RES and TAA until being culled at week 10 (protective group). In the model group, we documented the induction of hepatic fibrosis and upregulation of tumor necrosis factor-α (TNF-α), NF-kB, inducible nitric oxide synthase (iNOS), HIF-1α and the profibrotic biomarkers alpha-smooth muscle actin (α-SMA) and matrix metalloproteinase-9 (MMP-9) that was significantly (p ≤ 0.0014) ameliorated by RES. RES also significantly (p ≤ 0.0232) reduced triglycerides (TG), cholesterol (CHOL), very low-density lipoprotein (vLDL-C), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure, and heart rate (HR) induction by TAA. Also, a significant (p < 0.0001) positive correlation between TNF-α/NF-kB/iNOS/HIF-1α axis-mediated fibrosis and hypertension and liver injury biomarkers was observed. These findings suggest that in the hepatotoxic compound, TAA is associated with TNF-α/NF-kB/iNOS/HIF-1α-mediated fibrosis and hypertension, whilst being inhibited by RES.

Shams Eldeen, A. M., A. Fawzy, saeed soliman, E. A. Hegazy, L. Rashed, H. Hosny, W. A. Anwar, ahmed y ali, and A. A. Abdel Khalik, "Inflammatory biomarkers and severity of COVID-19: Cross sectional study among Egyptian patients.", The Egyptian journal of immunology, vol. 29, issue 2, pp. 96-105, 2022. Abstract

The newly emerging coronavirus disease 2019 (COVID-19) is characterized by multisystem inflammatory syndrome. The development of SARS-CoV-2 complications usually starts within few days following infection, and the severity of the disease determines its outcome. Vitamin D insufficiency is associated with risk of lung infections, also cell-based studies reported the ability of vitamin D to control enveloped virus growth. We aimed to investigate the relationship between the most eminent inflammatory biomarkers and the level of vitamin D aiming to provide a tool for early diagnosis and prediction of disease progression. The current study was approved by Research Ethics Committee (REC), Kasr Al-Ainy. After confirmation of being COVID-19 by PCR, the admitted patients were categorized as mild-moderate, and severe-critically ill based on clinical and radiologic data. The total levels of serum 25(OH)D, as well as other pro-inflammatory biomarkers were measured and were analyzed by receiver operating characteristic curve (ROC) analysis for detection of their association with COVID-19 disease severity and to determine their sensitivity and specificity at optimum cutoff points. The area under the curve (AUC) ROC for predicting COVID-19 disease severity was the highest (of 0.97) for vitamin D, inflammatory cytokines, liver enzymes, ferritin, and D-Dimer. In addition, high serum levels of creatinine, and elevated liver enzymes associated with severe-critical COVID-19. The low 25(OH)D was associated with the disease severity.

Al-Ani, B., Asmaa M. ShamsEldeen, Samaa S. Kamar, Mohamed A. Haidara, F. Al-Hashem, Mohammad Y. Alshahrani, Ahmed M. Al-Hakami, and A. Maarouf, "Lipopolysaccharide induces acute lung injury and alveolar haemorrhage in association with the cytokine storm, coagulopathy and AT1R/JAK/STAT augmentation in a rat model that mimics moderate and severe Covid-19 pathology", Clinical and Experimental Pharmacology and Physiology ., 2022.
2021
Estaphan Suzanne, S. E., Curpăn Alexandrina-Stefania, Khalifa Dalia, R. Laila, Ciobica Alin, Trus Constantin, Ali Mahmoud, and S. E. Asmaa, "Combined Low Dose of Ketamine and Social Isolation: A Possible Model of Induced Chronic Schizophrenia-Like Symptoms in Male Albino Rats", Brain sciences, 2021.
Aboulhoda, B. E., L. A. Rashed, H. A. Ahmed, Eman MM Obaya, W. Ibrahim, Marwa AL Alkafass, Sarah A Abd El‐Aal, and A. M. Shams Eldeen, "Hydrogen sulfide and mesenchymal stem cells‐extracted microvesicles attenuate LPS‐induced Alzheimer's disease", Journal of Cellular Physiology, vol. 236, issue 8, pp. 5994-6010, 2021.
Fares, A. E., H. Gabr, A. M. Shamseldeen, Haithem A. M. Farghali, Mazen Mohamed Salem Mohamed Rizk, Bassem Essam Mahmoud, Ahmed Bakr Ahmed Tammam, Ayman Magdy Ahmed Mahmoud, Alaa Abdulfattah Mahmoud Suliman, Mohamed Abdelhamid Ali Ayyad, et al., "Implanted subcutaneous versus intraperitoneal bioscaffold seeded with hepatocyte-like cells: functional evaluation", Stem Cell Research and Therapy, 2021.
Shamseldeen, A. M., M. Hamzawy, N. A. Mahmoud, L. Rashed, S. S. Kamar, L. A. Harb, and N. Sharawy, "Inhibition of endoplasmic reticulum stress and activation of autophagy-protect intestinal and renal tissues from western diet-induced dysbiosis and abrogate inflammatory response to LPS: role of vitamin E.", Journal of Biological Regulators and Homeostatic Agents, vol. 35, issue 2, pp. 457-471, 2021.
Ammar, H. I., A. M. Shamseldeen, H. S. Shoukry, H. Ashour, S. S. Kamar, L. A. Rashed, M. Fadel, A. Srivastava, and S. Dhingra, "Metformin impairs homing ability and efficacy of mesenchymal stem cells for cardiac repair in streptozotocin-induced diabetic cardiomyopathy in rats", American Journal of Physiology-Heart and Circulatory Physiology, vol. 320, issue 4, pp. H1290-H1302, 2021.
ShamsEldeen Asmaa M, Marwa Nagi, Mehesen, Aboulhoda Basma Emad, Rashed Laila Ahmed, Elsebaie Mohamed Mahmoud, mohamedenas ahmed, and G. M. Mohammed, "Prenatal intake of omega-3 promotes Wnt/β-catenin signaling pathway, and preserves integrity of the blood–brain barrier in preeclamptic rats", Physiological Reports, vol. 9, issue 12, 2021.
ShamsEldeen Asmaa M, H., Al-Ani Bahjat, Ebrahim Hasnaa A, R. Laila, Badr Amul M, Attia Abeer, Farag Ayman M, S. S. Kamar, Haidara Mohamed A, Al Humayed Suliman, et al., "Resveratrol suppresses cholestasis-induced liver injury and fibrosis in rats associated with the inhibition of TGFβ1–Smad3–miR21 axis and profibrogenic and hepatic injury biomarkers", Clinical and Experimental Pharmacology and Physiology ., 2021.
Hussein, R. E., E. d Laila Ahmed RASHED, B. E. Aboulhoda, G. M. A. Aziz, E. G. Abdelhady, Sarah A Ab-AAL, A. Shamseldeen, M. M. Khalifa, and H. Morsi, "The Role of Thymoquinone in Mitigating Carbon Tetrachloride-Induced Hepatocellular Carcinoma in Rats: Targeting the CHOP-1/JNK/P38 MAPK, NFêB/TNF-á/IL-10, and Bax/Bcl-2/Caspase-3 Signalling Pathways", Folia Biologica, vol. 69, issue 1, pp. 1-9, 2021.
Mohammad Dallak, B., D. H. Abdel Kader, A. F. Dawood, M. A. Haidara, R. A. Eid, S. S. Kamar, A. M. Shams Eldeen, and B. Al-Ani, "Suppression of glomerular damage and apoptosis and biomarkers of acute kidney injury induced by acetaminophen toxicity using a combination of resveratrol and quercetin", Drug and chemical toxicology , 2021.
Ashour Hend, M., Gamal Sara Mahmoud, Sadek Nermeen Bakr, R. Laila, Hussein Rania Elsayed, Kamar Samaa Samir, Ateyya Hayam, Mehesen Marwa Nagi, and S. E. A. Mohammed, "Vitamin D Supplementation Improves Uterine Receptivity in a Rat Model of Vitamin D Deficiency: A Possible Role of HOXA-10/FKBP52 Axis", Frontiers in Physiology, 2021.
2020
El-Dina, S. S., L. Rashed, E. Medhat, B. E. Aboulhoda, A. D. Badawy, A. M. Shamseldeen, and M. Abdelgwad, "Active form of vitamin D analogue mitigates neurodegenerative changes in Alzheimer’s disease in rats by targeting Keap1/Nrf2 and MAPK-38p/ERK signaling pathways", Steroids, vol. 156, pp. 108586, 2020.
Ibrahim Ismail Dalia, Mohammed ShamsEldeen Asmaa, Ahmed Rashed Laila, Aly El Desoky Shama Ashraf, Salama Ashour Sara, and G. A. Alshaymaa, "Cardioprotective Potential of Zinc and Vitamin E Against Isoprenaline-Induced Myocardial Infarction in Albino Rats by Targeting Autophagy: A Histological and Biochemical Study", Egyptian Journal of Histology, 2020.
El-sayed, L. A., eman osama, M. N. Mehesen, L. A. Rashed, A. G. Aboulkhair, A. I. Omar, and A. M. Shamseldeen, "Contribution of angiotensin II in hepatic ischemia /reperfusion induced lung injury: Acute versus chronic usage of captopril", Pulmonary Pharmacology & Therapeutics, vol. 60, pp. 101888, 2020.
Dhingra, S., N. Sareen, Ejlal Abu‐El‐Rub, Hania I. Ammar, Weiang Yan, G. L. Sequiera, Asmaa M. ShamsEldeen, M. Moudgil, Rimpy Dhingra, Heba S. Shokry, et al., "Hypoxia‐induced downregulation of cyclooxygenase 2 leads to the loss of immunoprivilege of allogeneic mesenchymal stem cells", The FASEB Journal, 2020.
Abu‐El‐Rub Ejlal, Sareen Niketa, Lester Sequiera Glen, I. Ammar Hania, Yan Weiang, M. ShamsEldeen Asmaa, Rubinchik Ilan, Moudgil Meenal, S. Shokry Heba, A. Rashed Laila, et al., "Hypoxia‐induced increase in Sug1 leads to poor post‐transplantation survival of allogeneic mesenchymal stem cells", The FASEB Journal, 2020.
Dallak, M., F. Al-Hashem, M. A. Haidara, M. Abd Ellatif, S. S. Kamar;, A. M. ShamsEldeeen, A. F. Dawood, Hasnaa A. Ebrahim, and B. Al-Ani, "Suppression of thioacetamide-induced hepatic injury in rats by resveratrol: role of mammalian target of rapamycin (mtor) cell signaling. ", int. J. Morphol. . , vol. 38, issue (3), pp. 558-564, 2020.
Al-Hashem, F., M. Abd Ellatif, A. M. Shams Eldeen, S. S. Kamar, B. Al-Ani, and M. A. Haidara, "Vitamin E protects against the modulation of TNF-α-AMPK axis and inhibits pancreas injury in a rat model of L-arginine-induced acute necrotising pancreatitis", Archives of Physiology and Biochemistry, 2020.
2019
Shamseldeen, A., H. Ashour, H. S. Shoukry, M. Fadel, S. S. Kamar, M. Aabdelbaset, L. A. Rashed, and H. I. Ammar, "Combined treatment with systemic resveratrol and resveratrol preconditioned mesenchymal stem cells, maximizes antifibrotic action in diabetic cardiomyopathy", J Cell Physiol, 2019.
Shamseldeen, A. M., M. A. Eshra, L. A. Rashed, M. F. Amer, A. E. Fares, and S. S. Kamar, "Omega-3 attenuates high fat diet-induced kidney injury of female rats and renal programming of their offsprings.", archives of physiology and biochemistry, vol. 125, issue 4, pp. 367-377, 2019.
Eshra, M. A., L. A. Rashed, R. F. A. Eltelbany, H. Omar, and A. M. Shamseldeen, "Omega-3 Modulates Anxiety and Improves Autistic like Features Induced by High Fat Diet but not Valproate", Neurology, Psychiatry and Brain research, vol. 33, pp. 11-21, 2019.
Ashour, H., M SHAMSELDEEN ASMAA, R. Laila, H. S. Shoukry, H ELSAYED MOHAMED, M. Mohamed, SAFINAZ SALAH-ELDIN, S. H. E. R. E. E. N. ABD, and H. I. Ammar, "Resveratrol Improves Cardiac Functions of the Diabetic Cardiomyopathy Rats Via Modulation of AMP-Activated Protein Kinase and the Phosphorylated Glycogen Synthase Kinase-3 (3", The Medical Journal of Cairo University, vol. 87, 2019.
Haidara, M. A., B. Al-Ani, I. Bin-Jaliah, A. M. Shams Eldeen, and M. D. Morsy, "Vanadyl sulphate ameliorates biomarkers of endothelial injury and coagulation and thrombosis in a rat model of hyperglycaemia", Archives of Physiology and Biochemistry, 2019.
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