Hussein, R. E., E. d Laila Ahmed RASHED, B. E. Aboulhoda, G. M. A. Aziz, E. G. Abdelhady, Sarah A Ab-AAL, A. Shamseldeen, M. M. Khalifa, and H. Morsi, "The Role of Thymoquinone in Mitigating Carbon Tetrachloride-Induced Hepatocellular Carcinoma in Rats: Targeting the CHOP-1/JNK/P38 MAPK, NFêB/TNF-á/IL-10, and Bax/Bcl-2/Caspase-3 Signalling Pathways", Folia Biologica, vol. 69, issue 1, pp. 1-9, 2021.
Ebrahim, H. A., S. S. Kamar, M. A. Haidara, N. A. S. Latif, M. Abd Ellatif, A. M. Shams Eldeen, B. Al-Ani, and A. F. Dawood, "Association of resveratrol with the suppression of TNF-α/NF-kB/iNOS/HIF-1α axis-mediated fibrosis and systemic hypertension in thioacetamide-induced liver injury.", Naunyn-Schmiedeberg's archives of pharmacology, 2022. Abstract

Chronic liver injury can lead to hepatic failure and the only available method of treatment would be liver transplantation. The link between inflammation (TNF-α), nuclear factor-kappa B (NF-kB), nitrosative stress (iNOS) and hypoxia-inducible factor-1α (HIF-1α) in thioacetamide (TAA) induced liver fibrosis, and hypertension with and without the incorporation of the anti-inflammatory and antioxidant resveratrol (RES) has not been investigated before. Consequently, we injected rats with either 200 mg/kg TAA for 8 weeks starting at week 2 (model group) or pretreated them before TAA injections with RES (20 mg/kg) for 2 weeks and continued them on RES and TAA until being culled at week 10 (protective group). In the model group, we documented the induction of hepatic fibrosis and upregulation of tumor necrosis factor-α (TNF-α), NF-kB, inducible nitric oxide synthase (iNOS), HIF-1α and the profibrotic biomarkers alpha-smooth muscle actin (α-SMA) and matrix metalloproteinase-9 (MMP-9) that was significantly (p ≤ 0.0014) ameliorated by RES. RES also significantly (p ≤ 0.0232) reduced triglycerides (TG), cholesterol (CHOL), very low-density lipoprotein (vLDL-C), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure, and heart rate (HR) induction by TAA. Also, a significant (p < 0.0001) positive correlation between TNF-α/NF-kB/iNOS/HIF-1α axis-mediated fibrosis and hypertension and liver injury biomarkers was observed. These findings suggest that in the hepatotoxic compound, TAA is associated with TNF-α/NF-kB/iNOS/HIF-1α-mediated fibrosis and hypertension, whilst being inhibited by RES.

Shams Eldeen, A. M., A. Fawzy, saeed soliman, E. A. Hegazy, L. Rashed, H. Hosny, W. A. Anwar, ahmed y ali, and A. A. Abdel Khalik, "Inflammatory biomarkers and severity of COVID-19: Cross sectional study among Egyptian patients.", The Egyptian journal of immunology, vol. 29, issue 2, pp. 96-105, 2022. Abstract

The newly emerging coronavirus disease 2019 (COVID-19) is characterized by multisystem inflammatory syndrome. The development of SARS-CoV-2 complications usually starts within few days following infection, and the severity of the disease determines its outcome. Vitamin D insufficiency is associated with risk of lung infections, also cell-based studies reported the ability of vitamin D to control enveloped virus growth. We aimed to investigate the relationship between the most eminent inflammatory biomarkers and the level of vitamin D aiming to provide a tool for early diagnosis and prediction of disease progression. The current study was approved by Research Ethics Committee (REC), Kasr Al-Ainy. After confirmation of being COVID-19 by PCR, the admitted patients were categorized as mild-moderate, and severe-critically ill based on clinical and radiologic data. The total levels of serum 25(OH)D, as well as other pro-inflammatory biomarkers were measured and were analyzed by receiver operating characteristic curve (ROC) analysis for detection of their association with COVID-19 disease severity and to determine their sensitivity and specificity at optimum cutoff points. The area under the curve (AUC) ROC for predicting COVID-19 disease severity was the highest (of 0.97) for vitamin D, inflammatory cytokines, liver enzymes, ferritin, and D-Dimer. In addition, high serum levels of creatinine, and elevated liver enzymes associated with severe-critical COVID-19. The low 25(OH)D was associated with the disease severity.

Ashour, H., M SHAMSELDEEN ASMAA, R. Laila, H. S. Shoukry, H ELSAYED MOHAMED, M. Mohamed, SAFINAZ SALAH-ELDIN, S. H. E. R. E. E. N. ABD, and H. I. Ammar, "Resveratrol Improves Cardiac Functions of the Diabetic Cardiomyopathy Rats Via Modulation of AMP-Activated Protein Kinase and the Phosphorylated Glycogen Synthase Kinase-3 (3", The Medical Journal of Cairo University, vol. 87, 2019.
Shamseldeen, A., H. Ashour, H. S. Shoukry, M. Fadel, S. S. Kamar, M. Aabdelbaset, L. A. Rashed, and H. I. Ammar, "Combined treatment with systemic resveratrol and resveratrol preconditioned mesenchymal stem cells, maximizes antifibrotic action in diabetic cardiomyopathy", J Cell Physiol, 2019.
Asmaa, M., M. Moustafa, N MORCOS GEORGE, F MARWA, and M. D. Abdallah, "Vitamin D Supports (3-Cell Remodeling Capacity and Could Reduce High Fat Diet-induced Insulinitis in Pups Born to Diabetic Mothers", The Medical Journal of Cairo University, vol. 86, 2018.
Haidara, M. A., B. Al-Ani, I. Bin-Jaliah, A. M. Shams Eldeen, and M. D. Morsy, "Vanadyl sulphate ameliorates biomarkers of endothelial injury and coagulation and thrombosis in a rat model of hyperglycaemia", Archives of Physiology and Biochemistry, 2019.
Shamseldeen, A. M., M. Hamzawy, N. A. Mahmoud, L. Rashed, S. S. Kamar, L. A. Harb, and N. Sharawy, "Inhibition of endoplasmic reticulum stress and activation of autophagy-protect intestinal and renal tissues from western diet-induced dysbiosis and abrogate inflammatory response to LPS: role of vitamin E.", Journal of Biological Regulators and Homeostatic Agents, vol. 35, issue 2, pp. 457-471, 2021.
ShamsEldeen Asmaa M, Marwa Nagi, Mehesen, Aboulhoda Basma Emad, Rashed Laila Ahmed, Elsebaie Mohamed Mahmoud, mohamedenas ahmed, and G. M. Mohammed, "Prenatal intake of omega-3 promotes Wnt/β-catenin signaling pathway, and preserves integrity of the blood–brain barrier in preeclamptic rats", Physiological Reports, vol. 9, issue 12, 2021.
Estaphan Suzanne, S. E., Curpăn Alexandrina-Stefania, Khalifa Dalia, R. Laila, Ciobica Alin, Trus Constantin, Ali Mahmoud, and S. E. Asmaa, "Combined Low Dose of Ketamine and Social Isolation: A Possible Model of Induced Chronic Schizophrenia-Like Symptoms in Male Albino Rats", Brain sciences, 2021.
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