Publications

Export 23 results:
Sort by: Author Title Type [ Year  (Desc)]
Submitted
Al-Mokaddem, A. K., K. A. Ahmed, S. S. Abd El-Rahman, and E. Abdel-mawla, The Potential Protective Impact of Spirulina platensis Against Thioacetamide-Induced Liver Fibrosis in Rats, , Submitted. Abstract
n/a
2022
Hassan, B. B., A. K. Al-Mokaddem, H. A. Abdelrahman, A. Samir, and M. R. Mousa, "Cutaneous Tumors in Dogs: A Retrospective Epidemiological and Histological Study of 112 Cases", Advances in Animal and Veterinary Sciences, vol. 10, issue 1, pp. 170-182, 2022.
Al-Mokaddem, A. K., D. A. Abdel-moneam, R. A. Ibrahim, M. Saleh, and M. Shaalan, "Molecular identification, histopathological analysis and immunohistochemical characterization of non- pigmented Aeromonas salmonicida subsp. salmonicida in Mugil carinatus (Valenciennes, 1836)", Aquaculture Reports, vol. 24, pp. 101103, 2022.
2021
Gendy, A. M., M. M. Amin, A. K. Al-Mokaddem, and M. F. Abd Ellah, "Cilostazol mitigates mesenteric ischemia/reperfusion-induced lung lesion: contribution of PPAR-gamma, NF-kąppaB, and STAT3 crosstalk", Life Sciences, vol. 266: Pergamon, pp. 118882, 2021. Abstract

n/a

Gendy, A., A. Soubh, A. Al-Mokaddem, and M. K. El-Sayed, "Dimethyl fumarate protects against intestinal ischemia/reperfusion lesion: Participation of Nrf2/HO-1, GSK-3beta and Wnt/beta-catenin pathway", Biomedicine & Pharmacotherapy, vol. 134: Elsevier Masson, pp. 111130, 2021. Abstract

n/a

El-Shiekh, R. A., A. Salama, A. K. Al-Mokaddem, and E. A. Abdel-Sattar, "Gastroprotective effect of mucilage fraction from Solenostemma argel via cytoprotection and attenuation of oxidative stress, inflammation and apoptosis", Journal of Herbmed Pharmacology, vol. 10, no. 2: Shahrekord University of Medical Sciences, pp. 232–240, 2021. Abstract
n/a
Bakr, R. O., R. I. Amer, D. Attia, M. M. Abdelhafez, A. K. Al-Mokaddem, A. E. - N. G. El-Gendy, A. M. El-Fishawy, M. A. A. Fayed, and S. S. Gad, "In-vivo wound healing activity of a novel composite sponge loaded with mucilage and lipoidal matter of Hibiscus species", Biomedicine & Pharmacotherapy, vol. 135: Elsevier Masson, pp. 111225, 2021. Abstract
n/a
Gendy, A., M. R. Elnagar, A. Soubh, A. Al-Mokaddem, A. El-Haddad, and M. K. El-Sayed, "Morin alleviates hepatic ischemia/reperfusion-induced mischief: In vivo and in silico contribution of Nrf2, TLR4, and NLRP3", Biomedicine & Pharmacotherapy, vol. 138, pp. 111539, 2021. morin_liver.pdf
Mesalam, N. M., S. A. Aldhumri, S. A. Gabr, Marwa A Ibrahim, A. K. Al‑Mokaddem, and A. ‑M. E. Abdel‑Moneim, "Putative abrogation impacts of Ajwa seeds on oxidative damage, liver dysfunction and associated complications in rats exposed to carbon tetrachloride", Molecular Biology Reports, vol. 48, pp. 5305–5318, 2021. mesalam2021_article_putativeabrogationimpactsofajw.pdf
2020
Mahmoud, A. H., N. S. Metwally, E. R. Youness, S. E. E. - Toukhy, H. A. Elmalt, and A. K. Al-Mokaddem, "Antiproliferative Activity of Bombax ceiba Flower Extract against Mammary Gland Carcinoma in Rats", Sys Rev Pharm, vol. 11, issue 11, pp. 1406-1415, 2020.
Abdellatif, M. M., I. A. Khalil, Y. E. Elakkad, H. A. Eliwa, T. M. Samir, and A. K. Al-Mokaddem, "Formulation and characterization of sertaconazole nitrate mucoadhesive liposomes for vaginal candidiasis", International Journal of Nanomedicine, vol. 15: Dove Press, pp. 4079, 2020. Abstract
n/a
Abdellatif, M. M., I. A. Khalil, Y. E. Elakkad, H. A. Eliwa, T. M. Samir, and A. K. Al-Mokaddem, "Formulation and characterization of sertaconazole nitrate mucoadhesive liposomes for vaginal candidiasis", International Journal of Nanomedicine, vol. 15: Dove Press, pp. 4079, 2020. Abstract
n/a
Abdellatif, M. M., I. A. Khalil, Y. E. Elakkad, H. A. Eliwa, T. M. Samir, and A. K. Al-Mokaddem, "Formulation and characterization of sertaconazole nitrate mucoadhesive liposomes for vaginal candidiasis", International Journal of Nanomedicine, vol. 15: Dove Press, pp. 4079, 2020. Abstract
n/a
El-Emam, S. Z., A. A. Soubh, A. K. Al-Mokaddem, and D. M. Abo El-Ella, "Geraniol activates Nrf-2/HO-1 signaling pathway mediating protection against oxidative stress-induced apoptosis in hepatic ischemia-reperfusion injury.", Naunyn-Schmiedeberg's archives of pharmacology, 2020. Abstract

Geraniol (GOH) is a natural essential oil that possesses antioxidant, anti-inflammatory, and antiapoptotic properties by various signaling pathways. Liver ischemia-reperfusion injury (IRI) is a serious event that triggers liver dysfunction or even failure. Nuclear factor erythroid 2-related factor 2 (Nrf2), a transcriptional factor, maintains cellular defense mechanism through antioxidant and anti-inflammatory properties. To detect GOH effect against liver IRI through the activation of the Nrf2/HO-1 antioxidant pathway, five groups of rats were randomized to normal, sham, IR, GOH, and GOH/IR. Blood samples and liver tissues were collected to measure various biochemical parameters related to liver function, and oxidative stress as well as inflammatory and apoptotic indicators besides liver tissue histopathology was evaluated by light microscopy. GOH induces activation of Nrf2 along with the upregulation of HO-1 expression. Also, the antioxidant activity of GOH was shown by the elevation of total antioxidant capacity and GSH levels, together with normalizing malondialdehyde. Regarding the anti-inflammatory effect of GOH, it suppresses the levels of TNF-α, iNOS, and COX-2. Additionally, the antiapoptotic effect of GOH, Bax, and caspase-3, 9 were reduced in liver tissue. GOH is a promising hepatoprotective agent in liver IRI through the activation of Nrf2/HO-1 antioxidant pathway.

Abdelatty, A. M., M. I. Mandouh, A. K. Al-Mokaddem, H. A. Mansour, H. M. A. Khalil, A. A. Elolimy, H. Ford, O. A. A. Farid, A. Prince, O. G. Sakr, et al., "Influence of level of inclusion of Azolla leaf meal on growth performance, meat quality and skeletal muscle p70S6 kinase α abundance in broiler chickens.", Animal : an international journal of animal bioscience, pp. 1-10, 2020. Abstract

The interest in biodiesel production from oil-bearing seeds rather than soybean necessitates the scientific validation of other good quality protein sources that could substitute soybean meal in animal diets, particularly, broiler chickens where soybean meal constitutes a large portion of their diet. Therefore, the present study was conducted to investigate the effect of sun-dried Azolla leaf meal (ALM) as an unconventional dietary protein source in broiler chicken diet on growth performance, meat quality, skeletal muscle cell growth and protein synthesis through regulation of ribosomal protein S6 kinase (p70S6 kinase α). A total of 120 male Ross 308 broiler chicks were randomly allocated to three dietary treatments. Each treatment had four cages (i.e. replicates) with 10 birds/cage. The control group was fed with a corn-soy-based diet, the AZ5 group was supplemented with 5% ALM and the AZ10 group was supplemented with 10% ALM for 37 days. A 5-day trial was also conducted to measure the apparent nutrient digestibility. Growth performance parameters were measured weekly. At the end of the experiment, 12 birds from each group (3/cage) were euthanized and used for samplings. Inclusion of ALM tended to improve BW gain (P = 0.06) and increased feed intake (P < 0.01). Additionally, ALM decreased the percentage of breast meat cooking loss linearly (P < 0.01). In addition, ALM at a dose of 5% increased the production of propionate in the cecum (P = 0.01). Activation of breast muscle p70S6 kinase was higher when ALM was included in a dose-dependent manner (P < 0.01). The inclusion of ALM increased breast meat redness (P < 0.01); however, the lightness was within the normal range in all groups. Findings from our study suggest that ALM could be included in a broiler chicken diet up to 5% without any major negative effect on meat quality or performance, and it regulates muscle protein synthesis through activation of mammalian target of rapamycin/6S kinase signaling.

Hozyen, H. F., H. M. A. Khalil, R. A. Ghandour, A. K. Al-Mokaddem, M. Samer, and R. A. Azouz, "Nano selenium protects against deltamethrin-induced reproductive toxicity in male rats", Toxicology and Applied Pharmacology, vol. 408: Elsevier, pp. 115274, 2020. Abstract
n/a
Hozyen, H. F., H. M. A. Khalil, R. A. Ghandour, A. K. Al-Mokaddem, M. Samer, and R. A. Azouz, "Nano selenium protects against deltamethrin-induced reproductive toxicity in male rats", Toxicology and Applied Pharmacology, vol. 408: Elsevier, pp. 115274, 2020. Abstract
n/a
2019
Abdelatty, A. M., S. A. Mohamed, M. M. A. Moustafa, A. K. Al-Mokaddem, M. R. Baker, A. A. Elolimy, S. A. Elmedany, S. Hussein, O. A. A. Farid, O. G. Sakr, et al., "Nutrigenomic effect of conjugated linoleic acid on growth and meat quality indices of growing rabbit.", PloS one, vol. 14, issue 10, pp. e0222404, 2019. Abstractjournal.pone_.0222404.pdf

Conjugated linoleic acid was detected in rabbit caecotrophs, due to the presence of microbial lipid activity in rabbit cecum. However, the effect of CLA as a functional food in growing rabbit is not well established. Therefore, this study was conducted to determine the effect of CLA on production, meat quality, and its nutrigenomic effect on edible parts of rabbit carcass including skeletal muscle, liver, and adipose tissue. Therefore, seventy five weaned V-Line male rabbits, 30 days old, were randomly allocated into three dietary treatments receiving either basal control diet, diet supplemented with 0.5% (CLAL), or 1% CLA (CLAH). Total experimental period (63 d) was segmented into 7 days adaptation and 56 days experimental period. Dietary supplementation of CLA did not alter growth performance, however, the fat percentage of longissimus lumborum muscle was decreased, with an increase in protein and polyunsaturated fatty acids (PUFA) percentage. Saturated fatty acids (SFA) and mono unsaturated fatty acids (MUFA) were not increased in CLA treated groups. There was tissue specific sensing of CLA, since subcutaneous adipose tissue gene expression of PPARA was downregulated, however, CPT1A tended to be upregulated in liver of CLAL group only (P = 0.09). In skeletal muscle, FASN and PPARG were upregulated in CLAH group only (P ≤0.01). Marked cytoplasmic vacuolation was noticed in liver of CLAH group without altering hepatocyte structure. Adipocyte size was decreased in CLA fed groups, in a dose dependent manner (P <0.01). Cell proliferation determined by PCNA was lower (P <0.01) in adipose tissue of CLA groups. Our data indicate that dietary supplementation of CLA (c9,t11-CLA and t10,c12- CLA) at a dose of 0.5% in growing rabbit diet produce rabbit meat rich in PUFA and lower fat % without altering growth performance and hepatocyte structure.

2016
Al-Mokaddem, A. K., K. A. Ahmed, S. S. Abd El-Rahman, and E. Abdel-mawla, The Potential Protective Impact of Spirulina platensis Against Thioacetamide-Induced Liver Fibrosis in Rats, , 2016. Abstract

n/a

2015
Al-Mokaddem, A. K., K. A. Ahmed, and R. E. DOGHAIM, "Pathology of gastric lesions in donkeys: A preliminary study", Equine Veterinary Journal, vol. 47, no. 6, pp. 684–688, 2015. Abstract
n/a
Al-Mokaddem, A. K., K. A. Ahmed, and R. E. DOGHAIM, "Pathology of gastric lesions in donkeys: A preliminary study", Equine Veterinary Journal, vol. 47, no. 6, pp. 684–688, 2015. Abstract
n/a
2014
Adl, A., I. B. Shaheed, M. I. Shaalan, A. K. Al-Mokaddem, and A. E. Hassanien, Digital Pathological Services Capability Framework, , 2014. digital_pathology.pdf