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Soliman, A. S., M. S. Amer, A. A. Shamaa, D. Sabry, G. G. Shehab, and O. Hagag, "Using of Chitosan seeded with autologous undifferentiated Mesenchymal Stem Cells for Femoral Bone Defect Management in dog", Dogs. Research Journal of Pharmaceutical, Biological and Chemical Sciences (RJPBCS);, issue 6(4):1220-1231., 2015.
A.Hassan;, M. H. E. - K.; E., O. El-Tookhy;, D. S.A.;, G. G. S., and Ashraf A. Shamaa, "Use of heterogeneous differentiated mesenchymal stem cells as a cirrhotic liver cell therapy of: a canine model Experimental study. ", Proceeding of 4th international conference on tissue science and regenerative medicine, July 27-29 Rome, 2015.
Abu-Seida, A. M., and A. A. Shamaa, "Ultrasonography and Surgical Treatment of an Unusual Case of Urethral Calculus in an Arabian Horse", Journal of Equine Veterinary Science, issue 92, 2020.
Elham A. Hassan, A. I. Abdelgalil, Faisal A. Torad, and A. A. Shamaa, "Ultrasonographic Examination of the Mammary Glands of Lactating Jennies (Equus asinus). ", Pakistan Veterinary Journal 10/2015, 2015.
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Abu-Seida, A. M., and A. A. Shamaa, "Treatment of a congenital lateral patellar luxation by recession trochleoplasty in a donkey foal. (2022)", Equine Veterinary Education, issue 34 (1), pp. 35-39, 2022.
Elawady, M. A., M. M. Elmaghrabi, N. Ebrahim, M. A. Elawady, D. Sabry, A. Shamaa, and Alyaa, "Therapeutic Potential of Bone Marrow Derived Mesenchymal Stem Cells in Modulating Astroglyosis of Surgical Induced Experimental Spinal Cord Injury", Advances in Bioscience and Biotechnology, vol. 07, issue 06, 2016.
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Soliman, A. S., M. S. Amer, A. A. Shamaa, G. G. S. Dina Sabry, and O. H. Ayman Magdy Mostafa, "Study the efficacy of chitosan as a scaffold for management of experimentally induced femoral bone defect in dogs. ", Journal of the egyptian veterinary medical association Vol 75(1) 111-123., 2015.
Soliman, A. S., M. S. Amer, A. A. Shamaa, and G. G. S. Dina Sabry, "Study the efficacy of chitosan as a scaffold for management of experimentally induced femoral bone defect in dogs. ", Journal of the egyptian veterinary medical association Vol 75(1) 111-123, 2015.
Ahmed, A. S., A. A. Shamaa, and E. A. Hassan, "Sternal cartilage autograft for repair of full-thickness articular cartilage defect: An experimental study on equine model.Part 1: Clinical and radiographic study. ", 2nd International Conference and Exhibition on Orthopedics & Rheumatology August 19-21, Embassy Suites, Las Vegas, USA, 2013.
Ahmed, A. S., A. A. Shamaa, and E. A. Hassan, "Sternal cartilage autograft for repair of full-thickness articular cartilage defect: An experimental study on equine model. Part 2: Histopathological, histochemical and biochemical study", 2nd International Conference and Exhibition on Orthopedics & Rheumatology August 19-21, Embassy Suites, Las Vegas, USA, 2013.
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Hassan;, M. H., E. H.; O. E. -tookhyA. S. Ashraf A. Shamaa, D. S. Abdelfatah;, and G. G. Shehab, "Role of hepatocyte differentiated mesenchymal stem cells in treatment of experimentally induced liver cirrhosis.", Asian J. Anim. Sci., 10 (2): 120-130, 2016.
Shamaa, A., A. N. Abdallah, M. Bahr, and O. E. S. Tookhy, "A review: Multiple Sclerosis Treatment: Current Strategies and Future Hopes", Alexandria Journal of Veterinary Sciences, 2020.
98) Farghali, H. A., K. K. Ali, and A. A. Shamaa, "Review on The Common Surgical Affections in Sheep and Goats", Journal of Applied Veterinary Sciences, vol. 5, issue 3, pp. 40-48, 2020.
El-Rahma, S. A. S., M. S. Amer, M. H. Hassan, H. M. Fahmy, and A. A. Shamaa, "Repair of experimentally induced femoral chondral defect in a rabbit model using Lyophilized growth promoting factor extracted from horse blood platelets (L-GFequina)", Injury, issue Ms. No. JINJ-D-21- accepted02200R1, 2022.
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Shoukry, H. S., H. I. Ammar, L. A. Rashed, M. B. Zikri, A. A. Shamaa, S. G. Abou Elfadl, E. A. - A. Rub, S. Saravanan, and S. Dhingra, "Prophylactic supplementation of resveratrol is more effective than its therapeutic use against doxorubicin induced cardiotoxicity.", PloS one, vol. 12, issue 7, pp. e0181535, 2017. Abstract

Resveratrol (RSV), a polyphenolic compound and naturally occurring phytoalexin, has been reported to exert cardio-protective effects in several animal studies. However, the outcome of initial clinical trials with RSV was less effective compared to pre-clinical studies. Therefore, RSV treatment protocols need to be optimized. In this study we evaluated prophylactic versus therapeutic effect of resveratrol (RSV) in mitigating doxorubicin (Dox)-induced cardiac toxicity in rats. To investigate prophylactic effects, RSV was supplemented for 2 weeks along with Dox administration. After 2 weeks, Dox treatment was stopped and RSV was continued for another 4 weeks. To study therapeutic effects, RSV treatment was initiated after 2 weeks of Dox administration and continued for 4 weeks. Both prophylactic and therapeutic use of RSV mitigated Dox induced deterioration of cardiac function as assessed by echocardiography. Also RSV treatment (prophylactic and therapeutic) prevented Dox induced myocardial damage as measured by cardiac enzymes (LDH and CK-MB) in serum. Which was associated with decrease in Dox induced myocardial apoptosis and fibrosis. Interestingly our study also reveals that prophylactic use of RSV was more effective than its therapeutic use in mitigating Dox induced apoptosis and fibrosis in the myocardium. Therefore, prophylactic use of resveratrol may be projected as a possible future adjuvant therapy to minimize cardiotoxic side effects of doxorubicin in cancer patients.

Shamaa, A., D. E. Hanafy2, T. F. Khalifa, M. M. Salem, G. G. Shehab, N. M. Aly, and E. HASSAN, "Pressure-induced left ventricular hypertrophy in canine model of aortic stenosis using nylon tie", Acta Scientiarum. Biological Sciences, vol. 42, 2020.
Abuowarda1, M., M. Amer, A. Shamaa, A. A. G. Shehab3, and M. Hassan, "A preliminary study of endoscopic diagnosis of gastric ulcer in Egyptian donkeys (Equus asinus) parasitized by Gasterophilus intestinalis (Diptera: Oestridae) ", Bulgarian Journal of Veterinary Medicine, issue https://doi.org/10.47278/journal.ijvs. 2021, 2020.
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Ali, K. K., H. A. Farghali, and A. A. Shamaa, "Orthopedic surgical affection in sheep and goats in state of Kuwait", International Journal of Applied Research, vol. 6, issue 1, pp. 44-49, 2020.
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Mannaa M, S. AA, S. A, H. IM, R. AM, and A. - S. AM, "A novel surgical technique for treatment of cervical vertebral stenotic myelopathy (wobbler syndrome) in a filly", J Equine Vet Sci. 2023;104493. IF: 1.386, issue 2023;104493., 2023.
Sabry, D., A. Mostafa, S. Marzouk, W. Ibrahim, H. H. M. Ali, A. Hassan, and A. Shamaa, "Neupogen and mesenchymal stem cells are the novel therapeutic agents in regeneration of induced endometrial fibrosis in experimental rats.", Bioscience reports, vol. 37, issue 5, 2017 Oct 31. Abstract

Endometrial fibrosis is the presence of intrauterine adhesions (IUAs) after any uterine surgery or curettage and it results in infertility and recurrent pregnancy loss. We evaluated the role of human mesenchymal stem cells (hMSCs) as a therapeutic agent of endometrial fibrosis. We also compared the effect of MSCs with the effect of estrogen and neupogen either each alone or as a combined therapy with MSCs. This experimental study was performed on 84 albino rats which were divided into seven groups (=12 rats/group) as follows, 1: normal control rats, 2: induced fibrosis, 3: induced fibrosis that received oral estrogen, 4: induced fibrosis that received hMSCs, 5: induced fibrosis that received hMSCs and estrogen, 6: induced fibrosis that received neupogen, and 7: induced fibrosis that received hMSCs and neupogen. The extent of fibrosis, vascularization, and inflammation were evaluated by; qRT-PCR for interleukin 1 (IL-1), interleukin 6 (IL-6), TNF, vascular endothelial growth factor (VEGF), transforming growth factor-β (TGF-β), and RUNX; ELISA for connective tissue growth factor (CTGF); Western blotting for collagen-I; immunohistochemistry examination for VEGF and RUNX-2; and histopathological assessment. In therapeutic groups either by hMSCs alone or combined with estrogen or neupogen; fibrosis and inflammation (IL-1, IL-6, TNF, TGF-β, RUNX, CTGF, and collagen-I) were significantly decreased but vascularization (VEGF) was significantly increased (<0.05) compared with induced fibrosis group. The most significant result was obtained in fibrosis that received combined therapy of hMSCs and neupogen (=0.000). Stem cells and neupogen are a highly effective alternative regenerative agents in endometrial fibrosis.

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Faisal A. Torad, Ashraf A. Shamaa, Dina S. Abdel Fatah, Laila A. Rashed, and S. M. D. G. M. M. and Magdy Abdelhamid, "Long term evaluation of human umbilical cord blood mesenchymal stem cells in the management of total coronary occlusion in dogs (experimental study). ", Asian Journal of Animal Sciences; 9(6):266-279., 2015.
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Farghali, H. A., K. K. Ali, and A. A. Shamaa, "Incidence of the Most Common Surgical Affections among Sheep and Goats Admitted to a Referral Hospital in the State of Kuwait", Advances in Animal and Veterinary Sciences,, vol. 8, issue 2, pp. 41-57, 2020.
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Abdelmonema, M., N. N. Shahina, L. A. Rashed, H. A. A. Aminc, A. A. Shamaa, and A. A. Shaheena, "Hydrogen sulfide enhances the effectiveness of mesenchymal stem cell. therapy in rats with heart failure: In vitro preconditioning versus in vivo codelivery. ", Biomedicine & Pharmacotherapy , vol. 112, 2019.
el-Tookhy, O. S., A. A. Shamaa, G. G. Shehab, A. N. Abdallah, and O. M. Azzam, "Histological evaluation of experimentally induced critical size defect skin wounds using exosomal solution of mesenchymal stem cells derived microvesicles.", . International journal of stem cells , issue septamper 2, 2017.
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