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Seida, A. A., N. D. El Tanbouly, W. T. Islam, H. H. Eid, S. A. El Maraghy, and A. S. El Senousy, SUPPLEMENTARY MATERIAL Bioassay-guided fractionation of a hepatoprotective and antioxidant extract of pea by-product, , Submitted. Abstract
Hussein, M. E., E. A. S. Senousy, W. H. Abd-Elslam, K. A. Ahmed, H. I. El-Askary, S. M. Mouneir, and E. A. M. Fishawy, "Roselle Seed Oil and its Nano-Formulation Alleviated Oxidative Stress, Activated Nrf2 and Downregulated m-RNA Expression Genes of Pro-inflammatory Cytokines in Paracetamol-intoxicated Rat Model", Records of Natural Products, vol. 14, issue 1, pp. 1-17, 2020. roselle_seed_oil_and_its_nano-formulation_records_of_natural_products.pdf
Farag, M. A., A. S. El Senousy, S. H. El-Ahmady, A. Porzel, and L. A. Wessjohann, "Comparative metabolome-based classification of Senna drugs: a prospect for phyto-equivalency of its different commercial products.", Metabolomics : Official journal of the Metabolomic Society, vol. 15, issue 5, pp. 80, 2019. Abstract

INTRODUCTION: The demand to develop efficient and reliable analytical methods for the quality control of nutraceuticals is on the rise, together with an increase in the legal requirements for safe and consistent levels of its active principles.

OBJECTIVE: To establish a reliable model for the quality control of widely used Senna preparations used as laxatives and assess its phyto-equivalency.

METHODS: A comparative metabolomics approach via NMR and MS analyses was employed for the comprehensive measurement of metabolites and analyzed using chemometrics.

RESULTS: Under optimized conditions, 30 metabolites were simultaneously identified and quantified including anthraquinones, bianthrones, acetophenones, flavonoid conjugates, naphthalenes, phenolics, and fatty acids. Principal component analysis (PCA) was used to define relative metabolite differences among Senna preparations. Furthermore, quantitative H NMR (qHNMR) was employed to assess absolute metabolites levels in preparations. Results revealed that 6-hydroxy musizin or tinnevellin were correlated with active metabolites levels, suggesting the use of either of these naphthalene glycosides as markers for official Senna drugs authentication.

CONCLUSION: This study provides the first comparative metabolomics approach utilizing NMR and UPLC-MS to reveal for secondary metabolite compositional differences in Senna preparations that could readily be applied as a reliable quality control model for its analysis.

Hussein, M. E., E. A. S. Senousy, H. I. El-Askry, S. M. Mouneir, and A. M. El-Fishawy, "Immunomodulatory and anti-inflammatory activities of the defatted alcoholic extract and mucilage of Hibiscus sabdariffa L. leaves, and their chemical characterization", Journal of Pharmacognosy and Phytochemistry, vol. 8, issue 4, pp. 982-990, 2019. immunomodulatory_and_anti-inflammatory_activities.pdf
Seida, A. A., N. D. El Tanbouly, W. T. Islam, H. H. Eid, S. A. El Maraghy, and A. S. El Senousy, "Bioassay-guided fractionation of a hepatoprotective and antioxidant extract of pea by-product", Natural product research, no. ahead-of-print: Taylor & Francis, pp. 1–6, 2014. Abstract
El Senousy, A. S., M. A. Farag, D. A. Al-Mahdy, and L. A. Wessjohann, "Developmental changes in leaf phenolics composition from three artichoke cvs.(Cynara scolymus) as determined via UHPLC–MS and chemometrics", Phytochemistry, vol. 108: Elsevier, pp. 67–76, 2014. Abstract
Ahmed, M. S., N. D. El Tanbouly, W. T. Islam, A. A. Sleem, and A. S. El Senousy, "Antiinflammatory flavonoids from Opuntia dillenii (Ker-Gawl) Haw. flowers growing in Egypt", Phytotherapy Research, vol. 19, no. 9: Wiley Online Library, pp. 807–809, 2005. Abstract