Al-Fattah, A. A., N. A. H. Sadik, S. H, B. A, and M. Nabil, "Association of genetic variants of hemostatic genes with myocardial infarction in Egyptian patients.", Gene. , vol. 641, pp. 212-219, 2018.
El-Fattah, A. A., N. A. H. Sadik, O. G. Shaker, and A. M. Kamal, "Single Nucleotide Polymorphism in SMAD7 and CHI3L1 and Colorectal Cancer Risk", Mediators Inflamm, vol. 25, pp. 9853192, 2018.
El-Fattah, A. A., A. T. Fahim, N. A. H. Sadik, and B. M. Ali, "Resveratrol and dimethyl fumarate ameliorate depression-like behaviour in a rat model of chronic unpredictable mild stress.", Brain research, vol. 1701, pp. 227-236, 2018.
Abd-El Fattah, A. A., H. A. Darwish, N. Fathy, and S. A. Shouman, "Carbonic anhydrase inhibition boosts the antitumor effects of Imatinib mesylate via potentiating the antiangiogenic and antimetastatic machineries.", Toxicology and applied pharmacology, vol. 316, pp. 123-138, 2017 02 01. Abstract

Carbonic anhydrase inhibitors have emerged in the past few years as an interesting candidate for the development of novel unconventional strategies. Despite their effect in tumor regression via inhibition of tumor acidification, their potential role is not yet fully elucidated. Herein, we investigated whether acetazolamide (AZ) could modulate imatinib (IM) anticancer activity, both in breast cancer cells (T47D) and in isolated tumor specimens of Ehrlich ascites carcinoma (EAC). The impact of this combination on angiogenesis was evidenced by decreasing PDGF-A expression and enhancing that of TSP-1. In the meantime, AZ significantly suppressed IM-induced attenuation of VEGF secretion in T47D cells, most probably due to NO inhibition. The combination also dramatically decreased the metastatic activity of T47D cells by mitigating the protein levels of MMP-2 and -9 and phosphorylation of p38 MAPK, while increasing the expression of TIMP-1 and -2. In addition, a strong proapoptotic effect was observed in T47D cells after combining AZ and IM in terms of increased caspase-9 and -3 activities. Interestingly, these results were confirmed by the reduction in the isolated tumor volume, MVD, Ki-67 and VEGF expression. Eventually, the study provides a new therapeutic strategy for treating cancer.

Fattah, A. A. A., H. A. M. Darwish, N. Fathy, and S. Shouman, "Carbonic anhydrase inhibition boosts the antitumor effects of Imatinib mesylate via potentiating the antiangiogenic and antimetastatic machineries", Toxicol Appl Pharmacol, vol. 1, issue 316, pp. 123-138, 2017.
Fattah, A. A. A., N. A. H. Sadik, O. G. Shaker, and A. M. Kamal, "Are SMAD7 rs4939827 and CHI3L1 rs4950928 polymorphisms associated with colorectal cancer in Egyptian patients?", Tumour biology, vol. 37, issue 7, pp. 9387-9397, 2016.
MA, E. - G., Sadik NA, R. ER, and A. E. - F. AA, "Neuroprotective effect of EGb761(R) and low-dose whole-body γ-irradiationin a rat model of Parkinson's disease", Toxicol Ind Health, vol. 31, issue 12, pp. 1128-1143, 2015.
AA, A. E. - F., F. AT, Sadik NA, and A. BM, "Resveratrol and curcumin ameliorate di-(2-ethylhexyl) phthalate induced testicular injury in rats", General and comparative endocrinology, vol. 1, issue 225, pp. 45-54 , 2016.
Abd-El-Fattah, A. A., N. A. H. Sadik, O. G. Shaker, and M. L. Aboulftouh, "Differential MicroRNAs Expression in Serum of Patients with Lung Cancer, Pulmonary Tuberculosis, and Pneumonia.", Cell Biochem Biophys, vol. 67, issue 3, pp. 875-84., 2013.
El-Fattah, A. A. A., M. I. Hamed, S. - E. A. Sadek, and A. S. Abu-Elhana, "Insulin Resistance in Type II Diabetes Mellitus with Liver Cirrhosis", Global Journal of Pharmacology , vol. 7, issue 2, pp. 109-117,, 2013.