Mannose-binding lectin exon 1 polymorphisms in Egyptian patients with chronic hepatitis C virus infection
- Citation:
- Abdelaal, A., N. Mossad, H. A. Hafez, and N. Elsayed, "Mannose-binding lectin exon 1 polymorphisms in Egyptian patients with chronic hepatitis C virus infection", Comparative Clinical Pathology, vol. 23, no. 5, pp. 1339–1342, 2014.
Abstract:
Persistent infection with hepatitis C virus (HCV) is a major cause of liver cirrhosis and subsequently liver cancer. Mannose-binding lectin 2 (MBL2) plays an important role in innate immunity, and its genetic polymorphisms are associated with deficient serum level of MBL2 and with frequent and prolonged infections. This study was undertaken to investigate the association between polymorphisms of MBL2 gene and hepatitis C virus infection and its association with response to treatment. We determined MBL2 gene polymorphism within exon 1 in 51 Egyptian patients with chronic hepatitis C virus infection and 49 healthy blood donors. MBL2 gene mutations were determined by means of polymerase chain reaction and restriction fragment length polymorphism analysis. Codons 52 and 54 mutant genotypes were significantly lower in HCV cases: odds ratio (OR) 0.28, 95 {%} confidence interval (CI) 0.10 to 0.76, pþinspace}=þinspace}0.012; and OR 0.15, 95 {%} CI 0.04 to 0.55, pþinspace}=þinspace}0.004, respectively. While codon 57 mutant genotypes were significantly higher in HCV cases: OR 4.54, 95 {%} CI 1.56 to 13.23, and pþinspace}=þinspace}0.006. MBL2 mutant genotypes at codons 52 and 54 are a protective factor for HCV infection, while MBL2 mutant genotypes at codon 57 are a risk factor for HCV infection. MBL2 D allele at codon 52 and B allele at codon 54 are a protective factor for HCV infection, while C allele at codon 57 is a risk factor for HCV infection.
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