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Ramadan, A., B. M. Fouda, N. A. Sabry, and O. Refaat, "Association Analysis of ApoE Gene Polymorphism among Egyptian Patients with Alzheimer's Disease", Gene Reports, vol. 14, pp. 65-71, 2019. apo-e_paper.pdf
Elbadawy, A. M., A. M. Khidr, and A. A. Saleh, "Comparative Study of Implicit memory during Bispectral index guided total intravenous anaesthesia versus sevoflurane inhalation anesthesia", Egyptian Journal of Anaesthesia, vol. 31, issue 1, pp. 9-13, 2015.
Tawaal, M. E. E. S., N. S. Ghanem, A. A. Saleh, and E. A. Abdullah, "Could obesity mediate psychopathology and suicidal ideation in adolescents?An Egyptian study", Middle East Current Psychiatry, issue 23, pp. 168-174, 2016.
A, G., S. AA, E. AA, and L. S, "Effect of gender, obesity and neck circumference on the severity of obstructive sleep apnea in Egyptian patients", European Sleep Research Society 24 th congress, Basel, September 2018.
Saleh, A. A., A. A. El Latif, and T. A. Gowely, "Executive Dysfunction in the Remited State of Late Life Depression", World Psychiatric Association, Bucharest-Romania, June 2015.
Khalil, M. A., A. A. Saleh, S. M. Gohar, D. H. Khalil, and M. Said, "Optical coherence tomography findings in patients with bipolar disorder.", Journal of affective disorders, vol. 218, pp. 115-122, 2017 Apr 28. Abstract

BACKGROUND: Research in bipolar disorder suggests the presence of structural brain abnormalities. It is not clear whether these findings are trait markers or operate with the onset and progress with disease severity and duration. Optical coherence tomography (OCT) is a non-invasive technique that detects degenerative changes in the retina reflecting brain degeneration. This study aimed at detecting these changes and relating them to disease severity and clinical characteristics.

METHODS: A case-control study conducted in Psychiatry and Addiction Medicine hospital, Faculty of Medicine at Cairo University. Forty inpatients with bipolar disorder -according to the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) - were compared to forty matched healthy controls. Patients were subjected to the Structured Clinical Interview of DSM-IV (SCID-I), Hamilton Depression Rating Scale (HAM-D) and Young Mania Rating Scale (YMRS). Both patients and controls were subjected to OCT.

RESULTS: Patients showed thinning of Retinal Nerve Fiber Layer (RNFL) relative to control subjects in most of the OCT parameters including Right average (p<.001 and 95% CI [14.39, 19.84]), Lt average (p<.001 and 95% CI [13.03, 19.42]). Patients also showed decreased Ganglionic Cell Complex (GCC) significantly in Rt average (p=.002 and 95% CI [2.33, 9.78]), Lt average (p<.001) and 95% CI [4.47, 11.63]. Age at onset, number of episodes, and severity did not significantly correlate with OCT parameters.

LIMITATIONS: The small sample and absence of follow-up.

CONCLUSIONS: Patients with bipolar disorder show degenerative changes detected by OCT in relation to healthy controls.

M., N., B. M., A. E., and K. M., "Rapid Eye Movement Sleep Abnormalities in Female Adolescents with Borderline Personality", European Sleep Research Society 24th Congress, Basel, September, 2018.
NS, A., H. AHH, H. AM, and E. - B. HN, "Serum Interleukin-6 is related to lower cognitive functioning in elderly patients with major depression", Aging &Ment Health, vol. 22, issue 5, pp. 655-661, 2018.
Ali, N. S., A. H. H. Hashem, A. M. Hassan, A. A. Saleh, and H. N. El-Baz, "Serum interleukin-6 is related to lower cognitive functioning in elderly patients with major depression().", Aging & mental health, pp. 1-7, 2017 Mar 24. Abstract

BACKGROUND: There is an increased evidence of an association between inflammatory mediators, particularly serum IL-6, depression and cognitive impairment in the elderly. This study aims at exploring the relation of peripheral IL-6 to cognitive functions in elderly patients with major depressive disorder (MDD).

OBJECTIVES: (1) Assessment of serum IL-6 levels and cognitive functions in elderly patients suffering from major depression and comparing them to healthy age-matched control subjects; (2) correlation between serum IL-6 levels and clinical characteristics of depression and cognitive functions in these patients.

SUBJECTS AND METHODS: The study is an observational, case-control study. It consisted of 80 subjects, 40 with the diagnosis of MDD according to the Diagnostic and Statistical Manual of Mental Disorders (DSM IV-TR) with early onset (first episode before the age of 60) and 40 community-dwelling subjects. They were subjected to the Structured Clinical Interview according to DSM-IV, Montreal Cognitive Assessment, Montgomery Asberg Depression Rating Scale, and serum IL-6 assay using ELISA.

RESULTS: In the depression group, subjects had lower scores in cognitive testing, than the control group (p = 0.001). Serum IL-6 was found to have a negative correlation with cognitive testing in these patients even after controlling for the severity of depressive status and Body Mass Index (BMI) (p = 0.025).

CONCLUSIONS: MDD in elderly subjects is associated with decline in cognitive functions that may be related to peripheral IL-6 levels.

M., A., F. M., B. D., Y. O., and et al, "The Sociodemographic and Clinical Characteristics of Tramadol Dependence Among Egyptians and Their Relationship to the Associated Insomnia", Addictive Disorders & Their reatment, vol. 17, issue 2, pp. 98-106, 2018.
M., S., F. AA., M. A., and S. AA., "Suicide risk and personality traits among Egyptian patients with substance use disorders", Egyptian Journal of Psychiatry, vol. 39, pp. 15-22, 2018.
Pérez, E. B., "Translation of IACAPAP Textbook of Child and Adolescent Mental Health chapter 1.2 Epilepsy and Related Conditions", IACAPAP Textbook of Child and Adolescent Mental Health, U.S.A, American Academy of Child and Adolescent Psychiatry, 2017.
AA, S., A. RSAEHA, K. OO, S. NA, and et al, "Validation of Montreal Cognitive Assessment - Basic in a sample of elderly Egyptians with neurocognitive disorders", Aging Ment Health, vol. 9, pp. 1-7, 2018.
Saleh, A. A., N. E. M. Fayoumy, S. M. Gohar, and M. A. Khalil, "• Social and Non-social Cognitive Functions in Patients with Schizophrenia: A Comparative Neuropsychological and Neurophysiological study", Egyptian Journal of Neurology, Psychiatry, and Neuro-surgery, In Press.