Ahmed Moustafa

Citation:

Salman, A., M. Aon, A. Hussein, M. Salman, M. Tourky, A. Mahmoud, F. Aljarad, M. Elkaseer, H. E. - D. Shaaban, A. Moustafa, et al., "Impact of Hypothyroidism on Patients with Hepatocellular Carcinoma Undergoing Liver Transplantation.", International journal of general medicine, vol. 14, pp. 5711-5718, 2021.

Abstract:

Background: This work endeavored to explore the effect of hypothyroidism on mortality in subjects with HCC who underwent living-donor liver transplantation (LDLT).

Methods: This prospective study included 107 patients with HCC subjected to LDLT, divided into hypothyroid group (n=53) and euthyroid group (n=54). The primary objectives were overall and disease-free survival (DFS).

Results: Euthyroid and hypothyroid groups were comparable in all baseline characteristics except the age of patients. Overall survival (OS) of the whole group at 48 months was 68.8%, while the DFS was 60.2%. On univariate analysis, OS was negatively affected by the older age of the patients (p<0.001) or the donor (p<0.001), hypothyroidism (p=0.008), HBV (p=0.029), larger tumor size (p=0.023), and defective Milan criteria (p=0.022). On multivariate analysis, the age of the patients and donors was the independent factor affecting OS. On univariate analysis, DFS was negatively affected by older age of the patients (p < 0.001) or the donor (p=0.005), hypothyroidism (p=0.005), HBV (p=0.019), larger tumor size (p=0.023), and defective Milan criteria (p=0.020). On multivariate analysis, the age of the patients, thyroid status, and Milan criteria were the independent factors affecting DFS.

Conclusion: Hypothyroidism is a risk factor for worse outcomes in HCC patients after liver transplantation.