THE DUAL ROLE OF VITAMIN D IN OSTEOPOROSIS TREATMENT

Citation:
Aziz, A. M. T. A., and H. M. E. Zahed, "THE DUAL ROLE OF VITAMIN D IN OSTEOPOROSIS TREATMENT ", THE EGYPTIAN JOURNAL OF MEDICAL SCIENCES , vol. 39, issue 1, pp. 85-93 , 2018.

Abstract:

Background: Osteoporosis is a condition characterized by low bone mass and increased bone fragility, and increase the risk of fractures. Osteoporosis is attributed to interaction between endocrine, metabolic and mechanical factors. proinflammatory cytokines are involved in the regulation of osteoblasts and osteoclasts. There is growing evidence that vitamin D3 deficiency could be a contributing factor in the development of different chronic diseases and their complications. Vitamin D plays an im-portant role in normal calcium and bone homeostasis though stimulation of new bone formation and suppression of the production of pro-inflammatory cytokines.
Methods: fifty rats were included in the experiment and were divided in to five groups of ten rats in each group as the following:
group1: control group; group2: induced osteoporosis group; group3: induced osteoporosis received vitamin D for one month; group4: induced osteoporosis received vitamin D for two months; group 5: induced osteoporosis received vitamin D for three months. Serum samples were collected for estimation of inflammatory cytokines (IL1, IL 6, and TNF) and inflammatory cytokines (IL10 and IL13) and bone marker (RANKL, os-teocalcin, and ALP) by ELISA technique.
Results: vitamin D treatment suppress the inflammation and im-prove the immune system in addition to stimulation of new bone formation through inhibition of RANKL and stimulation of osteocalcin and ALP.
Conclusion: vitamin D can be considered an effective therapeutic agent for osteoporosis.

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