AMYLOID A INITIATED CARCINOGENESIS IN CHRONIC HCV PATIENTS BY UP¬REGULATING LNCRNA HOTAIR.

Citation:
Aziz, A. M. T. A., AMANY A. ABOU-ELALLA, and W. Fathy, "AMYLOID A INITIATED CARCINOGENESIS IN CHRONIC HCV PATIENTS BY UP¬REGULATING LNCRNA HOTAIR.", The Arab Journal of Laboratory Medicine, vol. 44, issue 2, pp. 493-501, 2019.

Abstract:

Background: Hepatitis C virus (HCV) infection is a worldwide health problem and is one of the main causes of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). HCC is one of the most common cancers worldwide and has a poor prognosis. Long noncoding RNAs (lncRNAs) have been identified as playing critical roles in cancer development and progression.
Aim: we investigated a novel diagnostic /prognostic biomarkers and effective therapeutic targets for HCCs.
Subjects &Method: 90 subjects were included in the study as follows. Group 1: 20 normal control subjects. Group 2:35 HCV patients. Group 3: 35 patients developed HCC on top of HCV. Serum analysis for studied groups for biochemical marker and amyloid A were assessed by ELISA. In addition, lncRNA HOTAIR expression was assessed by real time PCR.
Results: serum amyloid A is significantly higher in HCV and HCC compared to control. While no significant difference between HCV and HCC patients was found. While HOTAIR level was higher in HCC compared to HCV.
Conclusion: elevated serum amyloid A predispose to the occurrence of HCC in chronic HCV patients then HOTAIR induce tumor progression.
Key words: Amyloid A, HCV, HCC and lncRNA HOTAIR.

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