Publications

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Book
Maged, A. M., Covid-19 Infection and Pregnancy, , London, ELSEVIER, 2021.
Book Chapter
Maged, A. M., "management of gestational diabetes", Gestational diabetes: Intechopen, 2020.
Journal Article
El-Khayat, W., A. Maged, and H. Omar, " A comparative study between isosorbide mononitrate (IMN) versus misoprostol prior to hysteroscopy ", Middle East Fertility Society Journal, vol. 15, issue 4, pp. 278-280, 2010.
Mohamed, A. M. M., W. S. M. El-Sherbiny, and W. A. I. Mostafa, " Combined contraceptive ring versus combined oral contraceptive (30-μg ethinylestradiol and 3-mg drospirenone)", International journal of gynaecology and obstetrics, vol. 114, issue 2, pp. 145-8, 2011.
Maged, A. M., A. H. Gebril, and A. Abdelhafez, "2D and 3D ultrasound assessment of cesarean section scars and its correlation to intraoperative findings", Uterus & Ovary, vol. 2, issue e919, pp. 1-7, 2015. 919-5321-2-pb.pdf
Maged, A. M., A. E. - M. Ramzy, M. Aboulghar, S. G. H. Allah, A. H. Wahba, A. A. Y. ElKateb, and N. Hwedi, "3D ultrasound assessment of endometrial junctional zone anatomy as a predictor of the outcome of ICSI cycles", European Journal of Obstetrics & Gynecology and Reproductive Biology, vol. 212, issue 1, pp. 160-165, 2017. jz.pdf
Maged, A. M., H. Elsawah, A. Abdelhafez, A. Bakry, and W. A. I. Mostafa, "The adjuvant effect of metformin and N-acetylcysteine to clomiphene citrate in induction of ovulation in patients with Polycystic Ovary Syndrome.", Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, vol. 31, issue 8, pp. 635-8, 2015. Abstract

OBJECTIVES: To assess the adjuvant effect of metformin and N-acetylcysteine (NAC) to clomiphene citrate (CC) in induction of ovulation in Polycystic Ovary Syndrome (PCOS) patients.

STUDY DESIGN: 120 women with PCOS were randomly divided into three equal groups: group I received CC only, group II received CC plus NAC and group III received CC plus metformin.

RESULTS: There was a significant difference between group II and other two groups regarding average number of ovulatory follicles >18 mm (2.25 versus 1.75 and 1.89, respectively), but no significant difference between the three study groups regarding number of intermediate follicles 14-18 mm (4, 10 and 4, respectively). There was no significant difference between the three study groups regarding occurrence and laterality of ovulation, pregnancy rate per cycle but a significant difference between group II and other two groups regarding pregnancy rate per patient (20% versus 10% and 10%, respectively, p value 0.05). There was a highly statistically significant difference between group II and other two groups regarding peak endometrial thickness (7.3 ± 1.1 versus 5.4 ± 0.6 and 5.3 ± 0.6, respectively).

CONCLUSIONS: NAC as an adjuvant to CC for induction of ovulation improves ovulation and pregnancy rates in PCOS patients with beneficial impacts on endometrial thickness.

Maged, A. M., H. Elsawah, A. Abdelhafez, A. Bakry, and W. A. I. Mostafa, "The adjuvant effect of metformin and N-acetylcysteine to clomiphene citrate in induction of ovulation in patients with Polycystic Ovary Syndrome.", Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, pp. 1-4, 2015 Aug 04. Abstract

OBJECTIVES: To assess the adjuvant effect of metformin and N-acetylcysteine (NAC) to clomiphene citrate (CC) in induction of ovulation in Polycystic Ovary Syndrome (PCOS) patients.

STUDY DESIGN: 120 women with PCOS were randomly divided into three equal groups: group I received CC only, group II received CC plus NAC and group III received CC plus metformin.

RESULTS: There was a significant difference between group II and other two groups regarding average number of ovulatory follicles >18 mm (2.25 versus 1.75 and 1.89, respectively), but no significant difference between the three study groups regarding number of intermediate follicles 14-18 mm (4, 10 and 4, respectively). There was no significant difference between the three study groups regarding occurrence and laterality of ovulation, pregnancy rate per cycle but a significant difference between group II and other two groups regarding pregnancy rate per patient (20% versus 10% and 10%, respectively, p value 0.05). There was a highly statistically significant difference between group II and other two groups regarding peak endometrial thickness (7.3 ± 1.1 versus 5.4 ± 0.6 and 5.3 ± 0.6, respectively).

CONCLUSIONS: NAC as an adjuvant to CC for induction of ovulation improves ovulation and pregnancy rates in PCOS patients with beneficial impacts on endometrial thickness.

Maged, A. M., H. Elsawah, A. Abdelhafez, A. Bakry, and W. A. I. Mostafa, "The adjuvant effect of metformine and N-acetylcysteine to clomiphene citrate in induction of ovulation in patients with Polycystic Ovary Syndrome", Gynecological Endocrinology, vol. 31, issue 8, pp. 635–638, 2015. metformine_nac_final.pdf
Mohamed, A. M. M., G. Eid, N. Bassiony, D. S. Eldin, S. Dahab, and N. ElGhamry, "Association of biochemical markers with severity of preeclampsia and its correlation with pregnancy outcome", International journal of gynecology and obstetrics, vol. 136, issue 2, pp. 138 - 144, 2017. markers_in_pih.pdf
Maged, A. M., G. Aid, N. Bassiouny, D. S. Eldin, S. Dahab, and N. K. Ghamry, "Association of biochemical markers with the severity of pre-eclampsia", International journal of gynecology and obstetrics, 2016.
Maged, A. M., G. Aid, N. Bassiouny, D. S. Eldin, S. Dahab, and N. K. Ghamry, "Association of biochemical markers with the severity of pre-eclampsia.", International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, vol. 136, issue 2, pp. 138-144, 2017 Feb. Abstract

OBJECTIVE: To assess the association between pre-eclampsia severity and biochemical and ultrasonography markers.

METHODS: A retrospective study was undertaken of women with severe pre-eclampsia (group 1, n=90), mild pre-eclampsia (group 2, n=90), or a normal pregnancy (group 3, n=90) who attended a hospital in Egypt in October 2013-April 2015. Associations between pre-eclampsia and biochemical, cardiotocography, and ultrasonography markers were investigated.

RESULTS: There were significant differences between the groups in C-reactive protein (331.44±112.38, 251.43±59.05, and 23.81±16.19 nmol/L; P≤0.05 for all), platelet count (113.40±36.72, 172.93±57.60, and 212.68±70.00×10(9) /L; P≤0.05 for group 1 comparisons), alanine transaminase (52.24±14.83, 38.34±13.12, and 23.11±6.92 U/L; P≤0.05 for group 1 comparisons), and serum uric acid (600.80±117.19, 481.83±118.97, and 243.89±53.54 μmol/L; P=0.050 for group 3 comparisons). Cardiotocography score was worse among women with severe pre-eclampsia than among those in the other two groups (P=0.039 for both comparisons). Biophysical profile score and umbilical artery resistance index differed by group (P≤0.05 for all). Middle cerebral artery resistance index was lower among women with severe pre-eclampsia (P≤0.05).

CONCLUSION: The levels of C-reactive protein, blood urea nitrogen, serum uric acid, and alanine transaminase, and the platelet count were linked with the presence and severity of pre-eclampsia.

Maged, A. M., "Authors response to article retraction", The European Journal of Contraception & Reproductive Health Care, vol. 28, issue 2, pp. 147-149, 2023.
Maged, A. M., and W. A. I. Mostafa, "Biochemical and ultrasonographic predictors of outcome in threatened abortion", Middle East Fertility Society Journal , vol. 18, issue 3, pp. 177–181, 2013.
Maged, A. M., A. G. M. A. G. Hassan, and N. A. Shehata, "Carbetocin versus oxytocin for prevention of postpartum hemorrhage after vaginal delivery in high risk women", J Matern Fetal Neonatal Med, vol. 29, issue 4, pp. 532-536., 2016. carbetocin.pdf
Maged, A. M., A. G. M. A. Hassan, and N. A. A. Shehata, "Carbetocin versus oxytocin for prevention of postpartum hemorrhage after vaginal delivery in high risk women.", The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, vol. 29, issue 4, pp. 532-6, 2016. Abstract

OBJECTIVE: To compare effectiveness and tolerability of carbetocin versus oxytocin in prevention of postpartum hemorrhage (PPH) after vaginal delivery.

METHODS: A prospective double-blinded randomized study conducted on 200 pregnant women randomized into two groups: Group 1 (100 women) received single 100 μg IM dose of carbetocin and Group 2 received of 5 IU oxytocin IM. Both groups received their drug after fetal and before placental delivery.

RESULTS: There was a statistically significant difference between the two study groups regarding amount of bleeding (337.73 ± 118.77 versus 378 ± 143.2), occurrence of PPH (4 versus 16%), need for other uterotonics (23 versus 37%) and hemoglobin difference between before and after delivery (0.55 ± 0.35 versus 0.96 ± 0.62) (all being lower in carbetocin group) and measured hemoglobin 24 h after delivery (being higher in carbetocin group); however, there was no significant difference between the two study groups regarding occurrence of major PPH and the need for blood transfusion. Women in carbetocin group showed a statistically significant lower systolic and diastolic blood pressure immediately after delivery and at 30 and 60 min than women in oxytocin group. There was no significant difference between the two study groups regarding occurrence of nausea, vomiting, flushing, dizziness, headache, shivering, metallic taste, dyspnea, palpitation and itching. Women in carbetocin group experienced tachycardia more than women in oxytocin group.

CONCLUSIONS: Carbitocin is a better alternative to traditional oxytocin in prevention of PPH after vaginal delivery with minimal hemodynamic changes and similar side effects.

Maged, A. M., A. G. M. A. Hassan, and N. A. A. Shehata, "Carbetocin versus oxytocin in the management of atonic post partum haemorrhage (PPH) after vaginal delivery: a randomised controlled trial", Archives of gynecology and obstetrics, vol. 293, pp. 993-999, 2016. 13_carbetocin_ttt_arch.pdf
Maged, A. M., A. G. M. A. Hassan, and N. A. A. Shehata, "Carbetocin versus oxytocin in the management of atonic post partum haemorrhage (PPH) after vaginal delivery: a randomised controlled trial.", Archives of gynecology and obstetrics, vol. 293, issue 5, pp. 993-9, 2016 May. Abstract

OBJECTIVE: The objective of this study is to compare the effectiveness and safety of carbetocin vs. oxytocin in the management of atonic post partum haemorrhage (PPH) after vaginal delivery.

METHODS: A prospective randomised study was conducted in which 100 pregnant women were randomised into 2 equal groups: group 1 received Carbetocin 100 µgm (Pabal(®) Ferring, UK) and group 2 received oxytocin 5 IU (Syntocinon(®), Novartis, Switzerland).

RESULTS: The amount of blood loss and the need for other uterotonics were significantly lower in the carbetocin group (811 ± 389.17 vs. 1010 ± 525.66 and 10/50 vs. 21/50). There was no significant difference between the carbetocin and oxytocin groups regarding occurrence of major PPH (6 vs. 11), the need for blood transfusion (6 vs. 9), the difference between blood haemoglobin levels before delivery and 24 h after delivery (0.6 ± 0.28 vs. 0.56 ± 0.25), respectively. There was no significant difference between the 2 study groups regarding both systolic and diastolic blood pressure measured immediately after the drug administration and at 30 and 60 min later. Regarding the drugs side effects, there was no significant difference between the 2 groups in the occurrence of nausea, vomiting, tachycardia, flushing, dizziness, headache, shivering, metallic taste, dyspnea, palpitations and itching.

CONCLUSIONS: Carbetocin is a better alternative to oxytocin in management of atonic PPH with non-significant hemodynamic changes or side effects .

Maged, A. M., M. Waly, R. M. Fahmy, A. S. Dieb, A. Essam, N. M. Salah, E. A. Hussein, and H. nabil, "Carbetocin versus rectal misoprostol for management of third stage of labor among women with low risk of postpartum hemorrhage", International journal of Gynecology and obstetrics, issue 148, pp. 238-242, 2020.
Rashwan, A. S., H. M. Gaffar, and A. M. Maged, "Comparative Study Between Continuous Use of Oxytocin Infusion Throughout The Active Phase of Labor Versus its Discontinuation and its Effect on The Course of Labor", The medical journal of Cairo university, vol. 79, issue 2, pp. 121-125, 2011.
Maged, A. M., G. A. Fattah, W. A. I. Mostafa, and D. Ahmed, "Comparative study between different biomarkers for early prediction of gestational diabetes mellitus", The journal of maternal-fetal & neonatal medicine, vol. 27, issue 11, pp. 1108–1112, 2014.
Maged, A. M., G. A. F. Moety, W. A. Mostafa, and D. A. Hamed, "Comparative study between different biomarkers for early prediction of gestational diabetes mellitus.", The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, vol. 27, issue 11, pp. 1108-12, 2014 Jul. Abstract

OBJECTIVE: To study various biomarkers in prediction of gestational diabetes mellitus (GDM).

PATIENTS AND METHODS: Prospective observational study included 400 pregnant women. Maternal serum sex hormone binding globulin (SHBG), high-sensitive C-reactive protein (hs-CRP), uric acid, creatinine and albumin were measured before 15 weeks of gestation. Patients were followed-up for development of GDM.

RESULTS: A total of 269 women were eligible for analysis. GDM complicated 27 (10.03%) of pregnancies. Hs-CRP levels were significantly higher and SHBG levels were significantly lower among women who subsequently developed GDM compared with normoglycemics. Uric acid, albumin and creatinine levels were not significantly different between both groups. For prediction of GDM, hs-CRP at a cutoff value of 2.55 mg/l showed a sensitivity and a specificity of 89% and 55%, respectively. SHBG at a cutoff value of 211.5 nmol/l showed a sensitivity and a specificity of 85% and 37%, respectively. Low SHBG with high hs-CRP predicted GDM with a sensitivity and specificity of 74.07% and 75.62%, respectively with an overall accuracy of 75.46%.

CONCLUSION: Hs-CRP and SHBG are important early predictors of GDM. Adding SHBG to hs-CRP improves specificity and serves good overall accuracy. Uric acid, creatinine and albumin have no role in GDM prediction.

El-Sherbini, M. M., A. M. Maged, O. M. Helal, M. O. Awad, S. A. El-Attar, J. A. Sadek, R. Elkomy, and M. A. Dawoud, "A comparative study between preoperative rectal misoprostol and intraoperative intrauterine administration in the reduction of blood loss during and after cesarean delivery: A randomized controlled trial", International journal of Gynecology and obstetrics, vol. 153, pp. 113-118, 2021. preoperative_misoprostol.pdf