Maged, A. M., M. Mosaad, A. M. AbdelHak, M. M. Kotb, and M. M. Salem, "The effect of hyoscine butylbromide on the duration and progress of labor in primigravidae: a randomized controlled trial.", The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, vol. 31, issue 22, pp. 2959-2964, 2017 Aug 02, 2018. Abstractthe_effect_of_hyoscine_butylbromide_on_the_duration_and_progress_of_labor_in_primigravidae_a_randomized_controlled_trial.pdf

OBJECTIVE: To assess the effect of hyoscine butylbromide (HBB) on duration of the first stage of labor in primigravdae.

METHODS: A case-control study conducted on 120 primigravida at term admitted in active labor were divided into three equal groups. A single dose of the drug (placebo or HBB 20 mg or HBB 40 mg) was injected intravenously slowly to groups A, B, and C. The duration of the first stage was calculated from the time of cervical dilatation of three to four centimeters in active labor until a fully dilated cervix was observed.

RESULTS: The duration of first stage was significantly shorter in women receiving 20 and 40 mg of HBB when controlled to control women (187.73 ± 20.92, 186.41 ± 19.40 versus 231.39 ± 33.14 min). There was no significant difference between the three study groups regarding duration of the second stage (36.76 ± 9.98, 35.72 ± 9.97 and 37.55 ± 10.57, respectively, p > .05), number of cases delivered by cesarean section (12.5%, 12.5%, and 15%, respectively, p > .05) and Apgar score of the neonates (p > .05). There was no significant difference between the three study groups regarding occurrence of side effects named dry mouth (7.5%, 12.5%, and 5%, p > .05), flushing (2.5%, 5% and 0%, p > .05), tachycardia (2.5%, 2.5%, and 2.5%, p > .05), or urinary retention (2.5%, 0%, and 0%, p > .05).

CONCLUSION: Intravenous injection of HBB decreases the duration of active phase of labor in primigravidae with no side effects.

Ahmed Mohamed Maged1, 5, A. H. Abbassy2, H. R. S. Sakr3, H. Elsawah1, H. Wagih1, A. I. Ogila1, and A. Kotb4, "Effect of swimming exercise on premenstrual syndrome", Archives of Gynecology and Obstetrics, vol. 297, issue 1, pp. 951-959, 2018. swimming_final.pdf
Maged, A. M., H. Rashwan, S. Abdelaziz, W. Ramadan, W. A. I. Mostafa, A. A. Metwally, and M. Katta, "Randomized controlled trial of the effect of endometrial injury on implantation and clinical pregnancy rates during the first ICSI cycle.", International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, vol. 140, issue 1, pp. 211-2167, 2017 Oct 19, 2018. Abstractrandomized_controlled_trial_of_the_effect_of_endometrial_injury.pdf

OBJECTIVE: To assess whether endometrial injury in the cycle preceding controlled ovarian hyperstimulation during intracytoplasmic sperm injection (ICSI) improves the implantation and pregnancy rates.

METHODS: Between January 1, 2016, and March 31, 2017, a randomized controlled trial was conducted at a center in Egypt among 300 women who met inclusion criteria (first ICSI cycle, aged <40 years, day-3 follicle-stimulating hormone <10 IU/L, normal serum prolactin, no uterine cavity abnormality). The women were randomly allocated using a web-based system to undergo endometrial scratch in the cycle preceding controlled ovarian hyperstimulation (n=150) or to a control group (n=150). Only data analysts were masked to group assignment. The primary outcomes were the implantation and clinical pregnancy rates at 14 days and 4 weeks after embryo transfer, respectively. Analyses were by intention to treat.

RESULTS: The implantation rate was significantly higher in the endometrial scratch group (41.3% [90/218]) than in the control group (30.0% [63/210]; P<0.001). The clinical pregnancy rate was also significantly higher in the endometrial scratch group (44.2% [61/138]) than in the control group (30.4% [41/135]; P<0.001).

CONCLUSION: Endometrial injury in the cycle preceding the stimulation cycle improved implantation and pregnancy rates during ICSI. CLINICALTRIALS.GOV: NCT02660125.

Maged, A. M., Hoda Abdelaal, E. Salah, H. Saad, H. Meshaal, A. Eldaly, M. A. Katta, and W. S. Deeb, "Prevalence and diagnostic accuracy of Doppler ultrasound of placenta accreta in Egypt.", The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, vol. 31, issue 7, pp. 933-939, 2017 Mar 22, 2018. Abstractprevalence_and_diagnostic_accuracy_of_doppler_ultrasound_of_placenta_accreta_in_egypt.pdf

OBJECTIVE: The objective of this study is to assess the prevalence of placenta accrete (PA) among those with placenta implanted over cesarean section (CS) scar and to evaluate the accuracy of Doppler ultrasound in diagnosis.

METHODS: A cross-sectional study included 100 patients with placenta previa (PP) anterior with at least one previous CS. Ultrasound and color Doppler were done to all participants and correlated with operative findings.

RESULTS: There was a significant difference between accrete and non-accrete group regarding maternal age (32.6 ± 5.01 versus 29.14 ± 4.89), and a highly significant difference regarding the postoperative hemoglobin (6.71 ± 1.156 versus 8.41 ± 1.257) and the number of previous CSs (p <.001). The abnormal Doppler findings showed a highly significant difference between the two groups as loss of retroplacental clear zone (87.3% versus 10.8%), intraplacental lacunae (93.7% versus 37.8%), hypervascularity in uterine bladder interface (47.6% versus 5.4%), and blood vessels invading myometrium (82.5% versus 18.9%) (p < .001). The sensitivity, specificity, PPV, NPV, and accuracy of loss of retroplacental clear were 87.3%, 89.19%, 93.2%, 80.49%, and 88%; intraplacental lacunae were 93.65%, 62.16%, 80.82%, 85.19%, and 82%; hypervascularity in uterine bladder interface were 47.62%, 94.59%, 93.75%, 51.47%, and 65%; dilated vessels over peripheral subplacental zone were 82.54%, 81.08%, 88.14%, 73.17%, and 82%, respectively. There was a highly significant difference between the two groups regarding surgical management with cesarean hysterectomy, occurrence of bladder injury, the need for intraoperative, and postoperative blood transfusion, ICU admission (p < .001).

CONCLUSION: The use of ultrasound together with the color Doppler allowed for better prediction of placental invasion of the myometrium prior to obstetrical intervention to improve the maternal and the fetal outcome.

Maged1, A. M., A. M. El‑Semary1, H. M. Marie1, D. S. Belal1, A. Hany1, E. F. Omran1, S. M. Y. Elbaradie2, and M. K. A. Mohamed1, "Effect of maternal obesity on labor induction in postdate pregnancy", Archives of Gynecology and Obstetrics, vol. 298, issue 1, pp. 45-50, 2018.
Maged*, A. M., H. Saad, E. Salah, H. Meshaal, M. Abdelbar, E. Omran, and A. Eldaly, "Urine test for HPV genotypes as a predictor of precancerous cervical lesions and for cervical cancer screening", International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, vol. 141, issue 1, pp. 332-336, 2018. hpv.pdf
Maged, A. M., H. Rashwan, M. Mahmoud, A. El-Mazny, M. Farouk, Doaa S. Belal, and H. M. Marie, "Effect of Prolonged GnRH Agonist Downregulation on ICSI Outcome in Patients With Endometriomas of Less Than 5 cm: A Randomized Controlled Trial", Reproductive Sciences, vol. 25, issue 10, pp. 1509-1514, 2018. gnrh_in_eo_final.pdf
Maged, A. M., W. S. Deeb, A. E. Amir, S. S. Zaki, H. Elsawah, M. A. Mohamady, A. A. Metwally, and M. A. Katta, "Diagnostic accuracy of serum miR-122 and miR-199a in women with endometriosis.", International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, vol. 141, issue 1, pp. 14-19, 2017 Nov 17, 2018. Abstractdiagnostic_accuracy_of_serum_mir-122.pdf

OBJECTIVE: To evaluate the value of serum microRNA-122 (miR-122) and miR-199a as reliable noninvasive biomarkers in the diagnosis of endometriosis.

METHODS: During 2015-2016, at a teaching hospital in Egypt, a prospective cohort study was conducted on 45 women with pelvic endometriosis and 35 women who underwent laparoscopy for pelvic pain but were not diagnosed with endometriosis. Blood and peritoneal fluid (PF) samples were collected; interleukin-6 (IL-6) was detected by enzyme-linked immunosorbent assay and miR-122 and miR-199a expression was measured by quantitative real-time polymerase chain reaction.

RESULTS: The serum and PF levels of IL-6, miR-122, and miR-199a were significantly higher in women with endometriosis than in controls (P<0.001 for all comparisons). Serum miR-122 expression was positively correlated with serum IL-6 (r=0.597), PF IL-6 (r=0.603), PF miR-122 (r=0.934), serum miR-199a (r=0.727), and PF miR-199a (r=0.653). Serum miR-199a expression was positively correlated with serum IL-6 (r=0.677), PF IL-6 (r=0.678), PF miR-122 (r=0.744), and PF miR-199a (r=0.932). Serum miR-122 and miR-199a had a sensitivity of 95.6% and 100.0% and a specificity of 91.4% and 100%, respectively, for the detection of endometriosis.

CONCLUSION: Serum miR-122 and miR-199a were significantly increased in endometriosis, indicating that these microRNAs might serve as biomarkers for the diagnosis of endometriosis. This article is protected by copyright. All rights reserved.

Maged, A. M., W. Deeb, S. Elbaradie, A. R. Elzayat, A. A. Metwally, M. Hamed, and A. Shaker, "Comparison of local and intra venous dexamethasone on post operative pain and recovery after caeseream section. A randomized controlled trial", Taiwanese Journal of Obstetrics & Gynecology, vol. 57, issue 1, pp. 346-350, 2018.