@article {166984, title = {Outcome of pediatric renal transplantation in urological versus non-urological causes of end stage renal disease: Does it matter?}, journal = {Journal of pediatric urology}, volume = {14}, year = {2018}, note = {n/a}, month = {2018 Apr}, pages = {166.e1-166.e7}, abstract = {

INTRODUCTION: Causes for end stage renal disease (ESRD) in children can be categorized into urological causes or non-urological causes. We sought to compare the outcomes of urological and non-urological causes of ESRD in children.

METHODS: Patients were divided into two groups: urological causes of ESRD versus non-urological causes of ESRD. All patients and donors had at least 6 months of follow-up. The main outcomes included the effect on complications and renal function. Comparisons were carried out using the chi-square test or the Student t-test. Multivariate logistic regression analysis was used to define the effect of different variables on the outcome of renal transplantation (Table).

RESULTS: Our study included 123 patients, 91 males. The mean age was 9 years and mean follow up was 46 months. Two-thirds of the patients had non-urological causes of ESRD. Overall survival was 100\%, and only one patient needed a graft nephrectomy 3 months after the transplant. The mean estimated glomerular filtration rate was 117~mL/min, and did not differ significantly between the two groups (p~=~0.13). Multivariable regression showed that female gender (OR 8.7, 95\% CI 2.9-26, p~=~0 0.0001) was associated with better renal function, while having a urological cause of ESRD (OR 0.28, CI 0.08-0.98, p~=~0 0.05) was associated with worse renal function. Non-urological causes of ESRD were significantly less likely to develop complications following renal transplantation (OR 0.28, CI 0.09-0.89, p~=~0 0.03).

CONCLUSION: Female patients with non-urological causes of ESRD are more likely to have better long-term renal functions, and less liable to develop complications following renal transplant.

}, issn = {1873-4898}, doi = {10.1097/JU.0000000000000142}, author = {Hussein, Ahmed Aly and Ahmed Ismail Shoukry and Fadel, Fatina and Morsi, Hani Abdel-Raouf and Hussein, Hussein Aly and Sheba, Mostafa and El-Khateeb, Nada and Abou-El Ela, Waseem and El-Sheemy, Mohamed and Kareem Daw and Shouman, Ahmed and Amr Lotfy and Hisham Badawy and Mohamed Eissa} }