@article {166101,
	title = {I-131 doping of silver nanoparticles platform for tumor theranosis guided drug delivery.},
	journal = {European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
	volume = {122},
	year = {2018},
	month = {2018 Sep 15},
	pages = {239-245},
	abstract = {<p>Nanotechnology may be applied in medicine where the utilization of nanoparticles (<=100 nm) for the delivery and targeting of theranostic agents is at the forefront of projects in cancer nano-science. This study points a novel one step synthesis approach to build up polyethylene glycol capped silver nanoparticles doped with I-131 radionuclide (I-doped Ag-PEG NPs). The formula was prepared with average hydrodynamic size 21 nm, zeta potential - 25 mV, radiolabeling yield 98 {\textpm} 0.76\%, and showed good in-vitro stability in saline and mice serum. The in-vitro cytotoxicity study of cold Ag-PEG NPs formula as a drug carrier vehicle showed no cytotoxic effect on normal cells (WI-38 cells) at a concentration below 3 μL/10 cells. The in-vivo biodistribution pattern of I-doped Ag-PEG NPs in solid tumor bearing mice showed high radioactivity accumulation in tumor tissues with maximum uptake of 35.43 {\textpm} 1.12 and 63.8 {\textpm} 1.3\% ID/g at 60 and 15 min post intravenous (I.V.) and intratumoral injection (I.T.), respectively. Great potential of T/NT ratios were obtained throughout the experimental time points with maximum ratios 45.23 {\textpm} 0.65 and 92.46 {\textpm} 1.02 at 60 and 15 min post I.V. and I.T. injection, respectively. Thus, I-doped Ag-PEG NPs formulation could be displayed as a great potential tumor nano-sized theranostic probe.</p>
},
	keywords = {Animals, Cell Line, cell survival, Drug Delivery Systems, Drug Liberation, Drug Stability, Humans, Iodine Radioisotopes, Male, Metal nanoparticles, Mice, Sarcoma, Silver, Theranostic Nanomedicine, Tissue Distribution},
	issn = {1879-0720},
	doi = {10.1016/j.ejps.2018.06.029},
	author = {Tamer M. Sakr and OM Khowessah and M. A. Motaleb and Abdel-Bary, A. and M. T. El-Kolaly and Swidan, Mohamed M}
}
