@article {227562,
	title = {Extracellular vesicle-microRNAs mediated response of bovine ovaries to seasonal environmental changes},
	journal = {Journal of Ovarian Research},
	volume = {16},
	year = {2023},
	note = {<p>n/a</p>
},
	month = {2023},
	pages = {101},
	abstract = {<p>Among the various seasonal environmental changes, elevated ambient temperature during the summer season is a main cause of stress in dairy and beef cows, leading to impaired reproductive function and fertility. Follicular fluid extracellular vesicles (FF-EVs) play an important role in intrafollicular cellular communication by, in part, mediating the deleterious effects of heat stress (HS). Here we aimed to investigate the changes in FF-EV miRNA cargoes in beef cows in response to seasonal changes: summer (SUM) compared to the winter (WIN) season using high throughput sequencing of FF-EV-coupled miRNAs. In addition to their biological relevance, the potential mechanisms involved in the packaging and release of those miRNAs as a response to environmental HS were elucidated.</p>
},
	isbn = {1757-2215},
	url = {https://doi.org/10.1186/s13048-023-01181-7},
	author = {Gad, Ahmed and Joyce, Kamryn and Menjivar, Nico Graham and Heredia, Daniella and Rojas, Camila Santos and Tesfaye, Dawit and Gonella-Diaza, Angela}
}
