Biventricular reverse remodeling and relationship with mitral valve prolapse after transcatheter closure of ASD secundum, a 3D echocardiographic study., El-Sisi, Amal, Dabour Shaheen, Fattouh Aya M., Assar Effat, Naguib Rasha, and AbdelMassih Antoine Fakhry , Journal of cardiovascular and thoracic research, Volume 12, Issue 1, p.15-19, (2020) Abstract

Mitral valve prolapse (MVP) is the most common anomaly of the mitral valve. Several studies have shown prevalence of MVP in atrial septal defect (ASD) especially secundum types (II). The aims of this study is to show the potential role of 3D echocardiography in improving the diagnosis of MVP and to depict the relationship between reverse remodeling of the right and left ventricles (RV, LV) and MVP after transcatheter closure of ASD II. Sixty patients underwent transcatheter closure of ASD II and completed follow up by 2D and 3D echocardiography in Cairo University Children Hospital before the procedure and at 24 hours, 1 and 6 months after the procedure. 3D echocardiography was more accurate than 2D echocardiography in detecting MVP frequency in ASD II patients (75% vs. 50%). Maximum statistically significant remodeling was detected by 3D echocardiography 1 month after the procedure (RV: LV ratio by 3D echocardiography 1.9±0.03 24 hours after the procedure vs. 1.6±0.03 1 months after the procedure, <0.01) while 2D echocardiography was delayed in detecting biventricular reverse remodeling. 3D derived RV: LV ratio was accurate in detecting MVP status with a sensitivity of 88%. MVP in ASD II may be related to Biventricular remodeling; 3D echocardiography is accurate in the detection of reverse remodeling as well as MVP in ASD II patients before and after device closure.

Transcatheter Closure of Perimembranous Ventricular Septal Defects Using Different Generations of Amplatzer Devices: Multicenter Experience., Mijangos-Vázquez, Roberto, El-Sisi Amal, Sandoval Jones Juan P., García-Montes José A., Hernández-Reyes Rogelio, Sobhy Rodina, AbdelMassih Antoine, Soliman Mohammed M., Ali Safaa, Molina-Sánchez Tatiana, et al. , Journal of interventional cardiology, Volume 2020, p.8948249, (2020) Abstract

Objectives: To demonstrate safety and efficacy of using different generations of softer Amplatzer™ devices for ventricular septal defect (VSD) closure to avoid serious complications at follow-up.

Background: Transcatheter closure of perimembranous ventricular septal defects (PmVSD) is a well-established procedure; however, it is associated with unacceptable incidence of complete heart block. Great advantages have been achieved by using softer devices for VSD transcatheter closure. The first and second generation of Amplatzer™ occluders (AVP II, ADO, and ADO II) seem to offer a safe and attractive alternative for this procedure. These devices can be delivered using either an arterial (retrograde) or venous (prograde) approach.

Methods and Results: Patients with congenital PmVSD who underwent transcatheter closure using ADO, ADO II, and AVP II devices were included. Primary end point was to determine efficacy and safety of these generations of devices and to determine the incidence of complications at follow-up (complete AV block and aortic/tricuspid/mitral regurgitation). One hundred and nineteen patients underwent VSD closure at a median age of 5 years (8 months-54 years). During the catheterization, there were only minor complications and at follow-up of 36 ± 25.7 months (up to 99 months), the closure rate was high of 98.3% and freedom from AV block was 100%.

Conclusions: The use of softer Amplatzer™ devices is a good alternative to achieve PmVSD closure safely with no risk of AVB during the procedure or at midterm follow-up.

Left ventricular rotational deformation changes by speckle tracking imaging before and 24 hours after transcatheter closure of large secundum atrial septal defects in children., El-Sisi, Amal Mahmoud, Gabr Abd El-Moneam Ahmed Mohammed, Afia Ali Abdellatif, Abu-Seif Hassan Saad, Agha Hala M., and AlSayad Tarek Kotb , Echocardiography (Mount Kisco, N.Y.), Volume 37, Issue 7, p.1065-1071, (2020) Abstract

BACKGROUND: Large atrial septal defects (ASDs) in children cause increased volume overload of the right side of the heart which in turn lead to impairment of left ventricular (LV) performance.

AIM: The aim of this study was to evaluate immediate LV rotational deformation changes in children with large ASDs post-device closure and removal of right ventricle (RV) volume overload.

PATIENTS AND METHODS: Twenty children who underwent transcatheter closure (TCC) of large secundum ASDs were included in the study. LV rotational deformation was assessed pre- and 24 hours post-device closure using speckle tracking imaging (STI).

RESULTS: 55% were females with mean age 6.1 ± 3.5 years. LV peak basal clockwise rotation improved significantly (-6.9 ± 2.6° before vs -10.3 ± 4.1° after TCC, P = .005), and time to peak clockwise rotation (345.1 ± 124.7 milliseconds (ms) before vs 282.2 ± 82.9 ms after closure, P = .02). There was no significant difference in apical rotational parameters including peak counterclockwise rotation (P > .05 for both). LV twist (11.3 ± 3.8° before vs 17.5 ± 7.1° after closure, P = .001) and torsion (2.1 ± 0.7°/cm before vs 3.1 ± 1.2°/cm after closure, P = .01) were significantly improved, mainly as the result of improvement of LV basal rotation. LV revealed a significant increase in LV end-diastolic volumes (P = .02) 24 hour after TCC with no significant change (P > .05) in end-systolic volumes after closure.

CONCLUSION: Increased peak LV twisting and torsion were attributed to the improved peak systolic clockwise basal rotation after TCC of large ASDs in children.

Percutaneous closure of ventricular septal defect associated with tunnel-shaped aneurysm using the Amplatzer duct occluder, Dilawar, Muhammad, Numan Mohammed, El-Sisi Amal, Gendi Salwa Morcos, and Ahmad Zaheer , Pediatric cardiology, Volume 29, Number 2, p.366–370, (2008) Abstract
Safety and efficacy of low-profile balloons in native coarctation and recoarctation balloon angioplasty for infants, Dilawar, Muhammad, El Said Howaida Galal, El-Sisi Amal, and Ahmad Zaheer , Pediatric cardiology, Volume 30, Number 4, p.404–408, (2009) Abstract
Helex septal occluder: feasibility study of closure of atrial septal defect, El-Sisi, Amal Mahmoud, Gendi Salwa, Dilawar Mohammed, and Numan Mohamed , Pediatric cardiology, Volume 29, Number 1, p.84–89, (2008) Abstract
Linear growth in relation to the circulating concentration of insulin-like growth factor-I and free thyroxine in infants and children with congenital cyanotic heart disease before vs. after surgical intervention, El-Sisi, Amal, Khella Aiman, Numan Mohamed, Dilwar Mohamed, Bhat Akhlaque, and SOLIMAN Ashraf , Journal of tropical pediatrics, Volume 55, Number 5, p.302–306, (2009) Abstract
Mechanical occlusion of the patent ductus arteriosus with Jackson coils, Elsisi, A., Tofeig M., Arnold R., Peart I., Kitchiner DJ, Bu'Lock FA, and Walsh KP , Pediatric cardiology, Volume 22, Number 1, p.29–33, (2001) Abstract
Cribriform amplatzer device closure of fenestrated atrial septal defects: feasibility and technical aspects, Numan, Mohammed, Sisi Amal EL, Tofeig Magdi, Gendi Salwa, Tohami Tohami, and El-Said Howaida G. , Pediatric cardiology, Volume 29, Number 3, p.530–535, (2008) Abstract