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Bruer, G. G., P. Hagedorn, M. Kietzmann, A. F. Tohamy, V. Filor, E. Schultz, S. Mielke-Kuschow, and J. Meissner, "Histamine H receptor antagonists enhance the efficacy of antibacterials against Escherichia coli.", BMC veterinary research, vol. 15, issue 1, pp. 55, 2019. Abstract

BACKGROUND: H receptor antagonists are commonly used for the treatment of allergic diseases. The aim of this study was to find out, if antihistaminic compounds like mepyramine have the ability to influence the activity of antibacterials. Therefore, the checkerboard method was chosen to detect these possible effects in vitro. Studies were performed with two different Escherichia coli (E. coli) strains as test microbes, treated with antibacterials in combination with mepyramine.

RESULTS: The minimum inhibitory concentration (MIC) of E. coli ATCC® 25922™ and E. coli PIG 01 was reduced by combinations of the tested antibacterials with mepyramine.

CONCLUSIONS: These results have to be confirmed in vivo, before the use of antihistamines should be considered as potential way to minimize the amount of used antibacterials for treatment of E. coli infections.

MM, H., S. MM, M. FF, T. AF, and E. D. KS, "Metabolic profile and hepatoprotective effect of Aeschynomene elaphroxylon (Guill. & Perr.). ", PLoS One, vol. 14, issue 1, pp. e0210576, 2019.
H, R., T. AF, S. WM, and P. A., "Ameliorative effects of bone marrow derived pancreatic progenitor cells on hyperglycemia and oxidative stress in diabetic rats", Acta Histochemica , vol. 120 , pp. 412–419, 2018.
Zaki, A. R., A. F. Tohamy, and Y. H. NourEl-houda, "Estimation of postmortem intervals by some biochemical changes and DNA degradation in rat brain and skeletal muscle tissues. ", Mansoura J. Forens. Med. Clin. Toxicol., vol. 25, issue 1, 2017.
A.A., K., I. M.A., T. A.F., A. A. A.A., and A. R. Zaki, "Protective Effect of Vitazinc on Chlorsan Induced Oxidative Stress, Genotoxicity and Histopathological Changes in Testicular Tissues of Male Rats", Int. J. Pharmacol., vol. 13, issue 1, pp. 22-32, 2017.
Hifnawy, M. S., H. A. Kassem, T. AF, and I. Y. Younis, "Study of the hypolipidemic activity of Egyptian Tropaeolum majus L. (garden nasturtium) as a promising therapeutic plant for treatment of cardiac diseases", Journal of Pharmacognosy and Phytochemistry, vol. 5, issue 6, 2016.
Mohammed, R. A., A. F. Tohamy, M. A. Elhady, and M. M. Soliman, "Subchronic toxicity of Deltamethrin and Tetramethrin in Nile Tilapia Fish", WJPPS, vol. 5, issue 10, 2016.
M.S, H., M. A.M, T. A.F, and M. F.Y, "Nephrotoxicity of gold nanoparticles in rats", Veterinary medical journal, vol. 61, issue 2, 2015.
F., F., T. A.F, and N. A, "12. Toxicopathological and genotoxic potential of perfluorooctanoic acid administration in albino rats", Egypt. J. Comp. Path & Clinical Path. , vol. 27, issue 1, pp. 1-17, 2014.
Shokry, M. M., A. Prince, M. Z. Attia, A. F. Tohamy, I. M. Ibrahim, and H. M. Farghalli, "Potential of camel-derived haemoglobin oxygen carriers as a blood substitute", Journal of Camelid Science, vol. 7, pp. 35 - 47, 2014.
IY, E., T. AF, K. HA, and E. HH, "Screening of the Potential antihypercholestermic activity of some Egyptain Herbs", Inter. J. of Pharmacotherapy, vol. 4, issue 2, pp. 74-79, 2014.
Prince, A. M., and A. F. Tohamy, "Mitochondrial alterations after cadmium-induced oxidative stress in mice brain", the IV Usual Veteriner Farmakoloji ve Toksikoloji kongresi, Turkey, 2013.