Reproductive toxic impact of subchronic treatment with combined butylparaben and triclosan in weanling male rats.

Citation:
Reproductive toxic impact of subchronic treatment with combined butylparaben and triclosan in weanling male rats., Riad, Madeha A., Abd-Rabo Marwa M., Abd El Aziz Samy A., El Behairy Adel M., and Badawy Mohamed M. , Journal of biochemical and molecular toxicology, 2018 Jan 19, (2018)

Abstract:

The effect of treatment with combined butylparaben and triclosan on male gonadal toxicity in weanling rats was investigated. All treated groups experienced atrophy in the ventral prostate and seminal vesicle, likewise significant depletion in the number and motility of sperm. Given individually or combined butylparaben and triclosan, significantly decreased testosterone, luteinizing hormone, and follicle-stimulating hormone levels. Individual treatment with tested compounds caused significant elevation in the Elevel, whereas combined treatment did not alter the Elevel. Testicular DNA damage was recorded in all treated groups. Moreover, the testicular malondialdehyde level was significantly elevated, along with a significant decrease in catalase enzyme activity in all treated groups. Superoxide dismutase enzyme activity was significantly decreased in the butylparaben-treated group, increased in the triclosan-treated group, and nonsignificantly changed the butylparaben-triclosan-treated group. The combined treatment produced an endocrine disturbance with a concomitant induction of testicular oxidative stress, which may represent a common mechanism of endocrine disruptor-mediated dysfunction.

Notes:

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