@article {228985,
	title = {Metagenome reveals caprine abomasal microbiota diversity at early and late stages of Haemonchus contortus infection.},
	journal = {Scientific reports},
	volume = {13},
	year = {2023},
	pages = {2450},
	abstract = {<p>Haemonchus contortus is one of the most detrimental gastrointestinal nematode parasites for small ruminants, especially in tropics and subtropics. Gastrointestinal nematode and microbiota share the same microhabitat; thus they interact with each other and their host. Metagenomics tools provide a promising way to examine the alterations in the gastric microbial composition induces by gastrointestinal parasites. In this study, we used metagenomics tools to characterize the impact of H. contortus infection on the caprine abomasal microbiota at early and late stage of infection and compared it with non-infected control. Our results showed that H. contortus infection caused a significant increase in abomasal pH at early (7~days post-infection) and late stage of infection (56~days post-infection). The analysis of alpha and beta diversity showed that the microbiota diversity both in number and in proportion was significantly affected at early and late stage of infection. All microbiota classes are impacted by H. contortus infection but Clostridia and Bacteroidia are more concerned. In infected animals, the genera Prevotella decreased at 7 and 56~days post-infection. Here we showed that the abomasal microbiota was significantly affected early after H. contortus infection, and these changes persist at late stage of the infection.</p>
},
	author = {Hadeer M. Aboshady and Choury, Alice and Montout, Laura and F{\'e}licit{\'e}, Yoann and Godard, Xavier and Jean-Christophe Bambou}
}
