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2022
M.Elimam, D., W. M. Eldehna, R. Salem, A. Bonardi, A. Nocentini, S. T.Al-Rashood, M. M. Elaasser, P. Gratteri, C. T.Supuran, and H.A.Allam, "Natural Inspired Ligustrazine-based SLC-0111 Analogues as Novel Carbonic Anhydrase Inhibitors", european journal of medicinal chemistry, vol. 228, pp. 114008, 2022.
Ibrahim, S. R. M., H. M. Abdallah, A. M. El-Halawany, G. A. Mohamed, A. A. Alhaddad, W. A. Samman, A. A. Alqarni, A. T. Rizq, K. F. Ghazawi, and R. S. El-Dine, "Natural Reno-Protective Agents against Cyclosporine A-Induced Nephrotoxicity: An Overview", Molecules, vol. 27, issue 22: MDPI, pp. 7771, 2022. Abstract
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Rahman, M. M., S. Bibi, M. S. Rahaman, H. R. H. Mohamed, and et al, "Natural therapeutics and nutraceuticals for lung diseases: Traditional significance, phytochemistry, and pharmacology", Biomedicine and pharmacotherapy , vol. 150, pp. 113041, 2022.
Rashidy, H. E., "The Nature of Climate Justice between protecting the environment and respecting human rights: the governing principles and international efforts to achieve them", Journal of Human Rights Studies, issue Issue 8 September 2022, Cairo: State Information Service, 2022.
El-Beshlawy, A., F. Rabah, H. M. Hamed, A. A. - S. Mahmoud, H. A. - H. Al-Wakeel, E. M. Abdelhamid, M. M. El-Sonbaty, and M. El Sissy, "Navigating Hemostasis of Bleeding Among Children With β-Thalassemia.", Journal of pediatric hematology/oncology, 2022. Abstract

Bleeding phenotype is reported in β-thalassemia patients. However, the underlying etiology remains elusive. We aimed to assess coagulation profile and the platelet aggregation in β-thalassemia children with bleeding diathesis. Fifty β-thalassemia children with a positive bleeding history were recruited. Bleeding phenotype was explored through full history taking and thorough clinical examination. Complete blood count, prothrombin time, international normalized ratio, and platelets aggregometry were performed for children with negative workup. Mucosal bleeding was manifest among most of our patients (96%). Two-third of patients had decreased aggregation with ristocetin (68%), adenine di-phosphate (64%), and arachidonic acid (64%). While half of the patients (48%) had deficient response to epinephrine. Collagen, ristocetin, and arachidonic acid induced aggregation were negatively correlated to frequency of blood transfusion (P=0.021, r=-0.325; P<0.001, r=-0.465; P=0.018, r=-0.333, respectively). Aggregation to collagen and epinephrine demonstrated a negative correlation with age (P=0.04, r=-0.287; P=0.03, r=-0.315). Deferiprone was associated with a deficient response to ristocetin and collagen when compared with deferasirox or no chelation (P=0.021 and 0.006, respectively). Impaired ristocetin response was linked to hydroxyurea (P=0.035). Platelets function defect should be considered in β-thalassemia patients with bleeding symptoms.

Abdelhalim, I., O. Hamdy, A. A. Hassan, and Salah Hassabelnaby, "Nd:YAG fourth harmonic (266-nm) generation for corneal reshaping procedure: An ex-vivo experimental study", PLOS ONE, vol. 16, issue (11) e0260494., pp. 1-10, 2022.
El-Demiry, S. M., M. El-Yamany, S. M. El-Gendy, H. A. Salem, and M. M. Saber, "Necroptosis modulation by cisplatin and sunitinib in hepatocellular carcinoma cell line.", Life sciences, vol. 301, pp. 120594, 2022. Abstract

Aim Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide. Systemic chemotherapy such as cisplatin and multi-targeted receptor tyrosine kinase inhibitors, including sunitinib, has marginal activity and frequent toxicity. Recently, necroptosis has been investigated as a potential target in treating cancer. Our aim is to evaluate the influence of cisplatin-sunitinib combination on HepG2 cells regarding their cytotoxicity and implicated intracellular pathways.

MATERIALS AND METHODS: The half-maximal inhibitory concentration (IC) values of cisplatin, sunitinib, and their combination were determined by Sulforhodamine-B assay. Bcl-2 and Bax protein levels were assayed using western blot. ELISA technique was used to measure pRIPK3/RIPK3, pERK/ERK, caspase-9, caspase-8, malondialdehyde (MDA), glutathione (GSH), and glutathione peroxidase (GPx).

KEY FINDINGS: Cisplatin-sunitinib combination exhibited a superior cytotoxic effect on HepG2 cells. Low concentrations of 4 μg/ml cisplatin and 2.8 μg/ml sunitinib showed significant Bcl-2 down-regulation and Bax up-regulation. The combined treatment also lowered pRIPK3/RIPK3 by 74% (p < 0.05) compared to the control. Significant increase in pERK/ERK by 3.9 folds over the normal control was also demonstrated. Moreover, combined treatment produced a significant 4 and 4.6 folds increase in caspase-9 and -8 levels. An increase in MDA level by 1.3 folds, a decrease in the intracellular GSH level by 63%, and an increase in GPx level by 1.17 folds were demonstrated.

SIGNIFICANCE: Sunitinib modulated cisplatin effect on cytotoxicity, oxidative stress, apoptosis, necroptosis and MAPK pathways. Sunitinib enhanced cisplatin-induced apoptosis and increased oxidative stress, but decreased necroptosis. Combined cisplatin and sunitinib might be promising for treating advanced HCC.

Khalil, H. A., and D. El-Sherif, "Needs Assessment on Land Governance in Egypt", Land Tenure Systems in North Africa, A Scoping Study, Addis Ababa, SLGA, GIZ, 2022.
El-Hawagry, M., A. A. Al‑Khalaf, A. M. Soliman, M. S. Abdel‑Dayem, and H. A. L. M. DHAFER, "The Nemestrinidae in Egypt and Saudi Arabia (Brachycera: Diptera)", Egyptian Journal of Biological Pest Control, vol. 32, issue 26, pp. 1-9, 2022. nemestrinidae_in_egypt_and_saudi_arabia.pdf
Hala A. ElGindy, Mohamed F. Mohamed, Magd A. Kotb, Z. Ezzeldin, Hussein S. Hamdy, Mohamed F. Hussein, and W. M. Elnaggar, "Neonatal Auditory Screening is a Necessity in The Neonatal Intensive Care Unit: Single Center Study", Pediatric Sciences Journal , vol. 2, issue 2, pp. 120-126, 2022.
Magd A. Kotb, S. Kaddah, S. T. El Sorogy, Reham Osama, Naglaa El Kinaaiee, Sayed Khedr, and M. Gad, "Neonatal Biliary Obstruction Caused by Pancreatic Kaposi Hemangioendothelioma", Pediatric Sciences Journal , vol. 2, issue 2, pp. 210-215, 2022.
Elassal, A. A., O. O. Al-Radi, R. S. Debis, Z. F. Zaher, G. A. Abdelmohsen, M. S. Faden, N. A. Noaman, A. R. Elakaby, M. E. Abdelmotaleb, A. M. Abdulgawad, et al., "Neonatal congenital heart surgery: contemporary outcomes and risk profile.", Journal of cardiothoracic surgery, vol. 17, issue 1, pp. 80, 2022. Abstractneonatal_congenital_heart_surgery_contemporary_outcomes_and_risk_profile.pdf

OBJECTIVE: Many studies still dispute the identification of independent risk factors that influence outcome after neonatal cardiac surgery. We present our study to announce the contemporary outcomes and risk profile of neonatal cardiac surgery at our institute.

METHODS: We designed a retrospective study of neonatal patients who underwent surgery for congenital heart diseases between June 2011 and April 2020. Demographic, operative, and postoperative data were collected from medical records and surgical databases. The primary outcome was the operative mortality (in-hospital death) and secondary outcomes included hospital length of stay, intensive care unit stay, duration of mechanical ventilation.

RESULTS: In total, 1155 cardiac surgeries in children were identified; of these, 136 (11.8%) were performed in neonates. Arterial switch operations (48 cases) were the most frequent procedures. Postoperatively, 11 (8.1%) patients required extracorporeal membrane oxygenation, and 4 (2.9%) patients had complete heart block. Postoperative in-hospital mortality was 11%. The median postoperative duration of mechanical ventilation, intensive care unit stay, and hospital length of stay were 6, 18, and 24 days, respectively.

CONCLUSION: The early outcomes of neonatal cardiac surgery are encouraging. The requirement of postoperative extracorporeal membrane oxygenation support, postoperative intracranial hemorrhage, and acute kidney were identified as independent risk factors of mortality following surgery for congenital heart defects in neonates.

Elmonem, M. A., K. R. P. Veys, and G. Prencipe, "Nephropathic Cystinosis: Pathogenic Roles of Inflammation and Potential for New Therapies.", Cells, vol. 11, issue 2, pp. 190, 2022. Abstract

The activation of several inflammatory pathways has recently been documented in patients and different cellular and animal models of nephropathic cystinosis. Upregulated inflammatory signals interact with many pathogenic aspects of the disease, such as enhanced oxidative stress, abnormal autophagy, inflammatory cell recruitment, enhanced cell death, and tissue fibrosis. Cysteamine, the only approved specific therapy for cystinosis, ameliorates many but not all pathogenic aspects of the disease. In the current review, we summarize the inflammatory mechanisms involved in cystinosis and their potential impact on the disease pathogenesis and progression. We further elaborate on the crosstalk between inflammation, autophagy, and apoptosis, and discuss the potential of experimental drugs for suppressing the inflammatory signals in cystinosis.

Ebedy, Y. A., E. I. Hassanen, A. M. Hussien, M. A. Ibrahim, and M. O. El Shazly, Neurobehavioral Toxicity Induced by Carbendazim in Rats and the Role of iNOS, Cox-2, and NF-κB Signalling Pathway., : Neurochem Res 47, 1956–1971 (2022). , 2022. Abstract

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Abdulaziz, K. S., M. H. Mohamed, D. R. A. Gad, L. S. E. - D. Mahmoud, E. E. A. Elshimy, and D. A. Osman, "Neuromodulation effect of laser acupuncture on female stress urinary incontinence: a randomized controlled trial", SPORT TK-Revista EuroAmericana de Ciencias del Deporte, vol. 11, issue 2, 2022. Website
Kissani, N., R. J. B. Ouadika, N. A. Kishk, O. Chaymae, E. A. A. Ibrahim, YoussoufaMaiga, R. Paul, and A. H. Ragab, "Neuromyelitis Optica Spectrum Disorders in Africa (A Narrative Review of 622 Cases)", Open Access Library Journal , vol. 9, pp. 1-11, 2022.
Ozaki, Y., K. Ohashi, N. Otaka, H. Ogawa, H. Kawanishi, T. Takikawa, L. Fang, M. Tatsumi, M. Takefuji, T. Enomoto, et al., "Neuron-derived neurotrophic factor protects against dexamethasone-induced skeletal muscle atrophy", Biochemical and Biophysical Research Communications, vol. 593, pp. 5-12, 2022.
Abdelkader, N. F., A. I. El-Batal, Y. M. Amin, A. M. Hawas, S. H. M. Hassan, and N. I. Eid, "Neuroprotective Effect of Gold Nanoparticles and Alpha-Lipoic Acid Mixture against Radiation-Induced Brain Damage in Rats", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, pp. 9640, 2022.
Ammar, R. A., A. F. Mohamed, M. M. Kamal, M. M. Safar, and N. F. Abdelkader, "Neuroprotective effect of liraglutide in an experimental mouse model of multiple sclerosis: role of AMPK/SIRT1 signaling and NLRP3 inflammasome.", Inflammopharmacology, vol. 30, issue 3, pp. 919-934, 2022. Abstract

The heterogeneous nature of multiple sclerosis (MS) and the unavailability of treatments addressing its intricate network and reversing the disease state is yet an area that needs to be elucidated. Liraglutide, a glucagon-like peptide-1 analogue, recently exhibited intriguing potential neuroprotective effects. The currents study investigated its potential effect against mouse model of MS and the possible underlying mechanisms. Demyelination was induced in C57Bl/6 mice by cuprizone (400 mg/kg/day p.o.) for 5 weeks. Animals received either liraglutide (25 nmol/kg/day i.p.) or dorsomorphin, an AMPK inhibitor, (2.5 mg/Kg i.p.) 30 min before the liraglutide dose, for 4 weeks (starting from the second week). Liraglutide improved the behavioral profile in cuprizone-treated mice. Furthermore, it induced the re-myelination process through stimulating oligodendrocyte progenitor cells differentiation via Olig2 transcription activation, reflected by increased myelin basic protein and myelinated nerve fiber percentage. Liraglutide elevated the protein content of p-AMPK and SIRT1, in addition to the autophagy proteins Beclin-1 and LC3B. Liraglutide halted cellular damage as manifested by reduced HMGB1 protein and consequently TLR-4 downregulation, coupled with a decrease in NF-κB. Liraglutide also suppressed NLRP3 transcription. Dorsomorphin pre-administration indicated a possible interplay between AMPK/SIRT1 and NLRP3 inflammasome activation as it partially reversed liraglutide's effects. Immunohistochemical examination of Iba microglia emphasized these findings. In conclusion, liraglutide exerts neuroprotection against cuprizone-induced demyelination via anti-inflammatory, autophagic flux activation, NLRP3 inflammasome suppression, and anti-apoptotic mechanisms, possibly mediated, at least in part, via AMPK/SIRT1, autophagy, TLR-4/ NF-κB/NLRP3 signaling. The potential mechanistic insight of Lira in alleviating Cup-induced neurotoxicity via: (1) AMPK/SIRT1 pathways activation resulting in the stimulation of brain autophagy flux (confirmed by lowering Beclin-1 and LC3-B protein expression). (2) Inhibition of NLRP3 inflammasome activation, as evidenced by reduced HMGB1, TLR-4, NF-κB and NLRP3 protein expression, alongside diminishing the activation of its downstream cascade as reflected by reduced levels of caspase-1 and IL-1β protein expression. (3) A possible modulating interplay between the previously mentioned two pathways.

Fouad, G. I., S. A. M. El‑Sayed, M. Mabrouk, K. A. Ahmed, and H. H. Beherei, "Neuroprotective Potential of Intranasally Delivered Sulforaphane‑Loaded Iron Oxide Nanoparticles Against Cisplatin‑Induced Neurotoxicity", Neurotoxicity Research , vol. 40, pp. 1479–1498, 2022.
Kowalczyk, J., B. Budzyńska, Ł. Kurach, N. E. S. Sayed, and K. Skalicka‐Woźniak, "Neuropsychopharmacological profiling of scoparone in mice", Scientific Reports, vol. 12, issue 822, pp. 1-14, 2022. paper_2.pdf
Abdul-Magead, I. A. M., and B. Abu-Ibrahim, "Neutron skin of neutron-rich nuclei", Physics Review C, vol. 105, issue January, pp. 014626, 2022. Website
Abdul-Magead, I. A. M., and B. Abu-Ibrahim, "Neutron skin of neutron-rich nuclei", PHYSICAL REVIEW C, vol. 105, pp. 014626, 2022. physical_review_c_105_014626_2022.pdf
Geweely, Neveen, S., H.A. Afifi, S. A AbdelRahim, G. MI Kamh, M.M Soliman, M. AbdelSattar, H.M Ali, M.Akrami, and M.Salem, Neveen Geweely Bioactivities of Six Plant Essential Oils against some Isolated Microbes from an Archaeological Limestone Statue at the Saqqara Excavation., , 2022. dr_neveen_geweely_2022.pdf
Youssef, D., S. Hassab-Elnaby, and S. R. Al-Sayed, "New 3D model for accurate prediction of thermal and microstructure evolution of laser powder cladding of Ti6Al4V alloy", Alexandria Engineering Journal, vol. 61, issue 5, pp. 4137-4158, 2022.