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2022
El Gendy, M. A. M., H. Hassanein, F. M. Saleh, F. Karimi-Busheri, M. Fanta, X. Yang, D. Tawfik, S. Morsy, M. Fahmy, and M. Hemid, "Hydrazonoyl chlorides possess promising antitumor properties", Life Sciences, vol. 295: Pergamon, pp. 120380, 2022. Abstract
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Esily, R. R., Y. Chi, D. M. Ibrahiem, and Y. Chen, "Hydrogen Strategy in decarbonization era: Egypt as a case study", International Journal of Hydrogen Energy, vol. 47, issue 43, pp. 18629-18647, 2022.
Kassem, A., E. F. S. Taha, A. Hassan, and A. H. Osman, "Hydrogen Sulfide Suppress the Pathological Alterations of Endocrine GlandsInduced by Gamma Irradiation and Cyclophosphamide.", International Journal of Pharmaceutical Sciences andClinical Research, vol. 2, issue 2, pp. 1-9, 2022.
NAZIH, M., M. Gobashy, Z. SALEM, K. Soliman, and A. Abdelhalim, "Hydrogeochemical and geophysical investigations to delineate underground water aquifer in arid regions: A case study, Gara oasis, Egypt", Contributions to Geophysics and Geodesy, vol. 52, issue 3, pp. 307 - 357, 2022. 423-article_text-802-1-10-20220930.pdf
Ghani, J., Z. Ullah, J. Nawab, H. R. H. Mohamed, and et al, "Hydrogeochemical Characterization, and Suitability Assessment of Drinking Groundwater: Application of Geostatistical Approach and Geographic Information System", Frontiers in environmental science , vol. 10, 2022.
Abu Salem, H., M. El-Ghamrawy, and A. Abdel-Motelib, "Hydrogeochemical processes and groundwater quality assessment of the Nubian Sandstone Aquifer System in El Farafra Oasis, Egypt. Egyptian Journal of Geology", Egyptian Journal of Geology, vol. 66, issue 1, 2022.
Yousif, I. A. H., E. M. A. el dine Tealab, A. A. A. Hady, and A. A. A. A. b, "Hydropedological Assessment of Wadi El-Raml at the Northwestern Coast of Egypt", Scientific African, vol. 17 , issue (2022) e01322, pp. 1-25, 2022.
Hassan, M. A., A. H. Al-Tohamy, and A. Kaood, "Hydrothermal characteristics of turbulent flow in a tube with solid and perforated conical rings", International Communications in Heat and Mass Transfer, vol. 134: Pergamon, pp. 106000, 2022. Abstract
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Heakal, F. E. - T., Y. B. Sarhan, M. A. Maamoun, A. M. Bakry, Y. K. Abdel-Monem, and I. M. Ghayad, "Hydrothermal Microwave-Assisted Fabrication of Nanohydroxyapatite Powder and Optimization of Its Nanocomposite Coatings on Magnesium Alloy for Orthopedic Applications", ACS Omega, vol. 7, issue 1, pp. 1021−1034, 2022.
Elsayed, A. A. A., E. L. - G. Ahmed, Z. K. Taha, H. M. Farag, M. S. Hussein, and K. AbouAitah, "Hydroxyapatite nanoparticles as novel nano-fertilizer for production of rosemary plants", Scientia Horticulturae, vol. 295, pp. 110851, 2022.
Rabee, R., S. Moustafa, M. A. Nessem, R. Tarek, M. G. Ramzy, E. S. Dessoky, A. Abdelkhalek, M. Z. M. Salem, and E. Aboelhana, "Hydroxypropyl Cellulose Loaded with ZnO Nanoparticles for Enhancing the Mechanical Properties of Papyrus (Cyperus papyrus L.) Strips", Bioresources , vol. 16, issue 2, pp. 2607-2625, 2022.
Abd-Elhameed, W. M., J. T. A. Machado, and Y. H. Youssri, "Hypergeometric fractional derivatives formula of shifted Chebyshev polynomials: Tau algorithm for a type of fractional delay differential equations", International Journal of Nonlinear Sciences and Numerical Simulation, vol. 23, no. 7-8, pp. 1253 – 1268, 2022. AbstractWebsite
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Chen, Y., Y. Ouyang, X. Chen, R. Chen, Q. Ruan, M. A. Farag, X. Chen, and C. Zhao, "Hypoglycaemic and anti-ageing activities of green alga Ulva lactuca polysaccharide via gut microbiota in ageing-associated diabetic mice.", International journal of biological macromolecules, vol. 212, pp. 97-110, 2022. Abstract

Ageing-related type 2 diabetes is a significant public health problem. Particularly, the number of cases and fatality rates of ageing-associated diabetes increase with population ageing. This study aimed to investigate the structural characterisation of Ulva lactuca polysaccharide (ULP) and the hypoglycaemic effect on ageing-associated diabetic mice using gut microbiota variation. Sugar residuals analysis showed that the purified ULP (ULP-1) comprised β-D-Xylp-(1→3)-β-D-Arap-(1→6)-β-D-Galp-(1→6)-β-D-Glcp linked to [→α-L-Rhap-(1→4)-β-D-GlcpA→] and α-D-Manp-(1→4)-α-L-Rhap(2SO)-(1→2)-α-L-Rhap(4SO)-(1→2)-α-L-Arap-(1→2)-α-L-Rhap-(1→ as its side chains at β-D-Glcp. Moreover, ULP modulated the expression levels of p16, MMP2, FoxO1, GLP-1/GLP-1R, STAT3, and GLUT4 to improve the status of ageing and diabetes, which was concurrent with the increased abundance of Dubosiella, Enterococcus, Romboutsia, Bifidobacterium, Kurthia, Clostridium_sensu_stricto_1, Corynebacterium, Faecalibaculum, Aerococcus and Vibrio. Notably, Dubosiella, Romboutsia, Bifidobacterium, Turicibacter and Clostridium_sensu_stricto_1 could serve as important intermediates for delaying ageing and diabetes. Additionally, the ULP-1 structure is strongly binding interaction with the target protein through hydrogen bonding and Van der Waals force, especially for GLP-1 (-10.34 kcal/mol), p16 (-10.51 kcal/mol) and GLP-1R (-8.57 kcal/mol). Moreover, the average length of the hydrogen bond was observed to be 2.36 MPa, which is smaller than that of the traditional hydrogen bond. Therefore, ULP has the potential to function as a nutraceutical to delay or prevent the development of ageing-related type 2 diabetes.

Elbendary, A., M. R. E. Abdel-Halim, R. Youssef, A. D. Halim, M. F. Elmasry, A. Gad, and E. D. A. Sharkawy, "Hypopigmented lesions in pityriasis lichenoides chronica patients: Are they only post-inflammatory hypopigmentation?", Australas J Dermatol, vol. 63, issue 1, pp. 68-73, 2022.
Zamzam, S. M., H. M. Abdelkader, G. Subedi, and O. A. Alhossainy, "Hypovitaminosis D and its relationship to nasal polyposis", Pan Arab Journal of Rhinology, 2022.
El-Kady, H., O. Amer, A. H. Ali, and H. Haggag, "Hysteretic Performance of Hybrid GFRP-Steel Reinforced Concrete Shear Walls: An Experimental Investigation", Journal of Cement Based Composites, vol. 3, issue 4, pp. 1-9, 2022.
Meshaal, H., E. Salah, E. Fawzi, M. Abdel-Rasheed, A. Maged, and H. Saad, "Hysteroscopic management versus ultrasound‑guided evacuation for women with first‑trimester pregnancy loss, a randomised controlled trial", BMC women health, vol. 22, issue 190, 2022.
Y, A. W., F. M. A. A. A. F. B. E. - D. M. A. W. N. N. A. L. D. A. I. Mostafa-Hedeab G, Sayed AboBakr Ali AH, W. N. A. Ahmed AF, Bahaa El-Deen MA, and A. L. DA, Idebenone regulates sirt1/Nrf2/TNF-α pathway with inhibition of oxidative stress, inflammation, and apoptosis in testicular torsion/detorsion in juvenile rats, , 2022.
Y, A. W., F. M. A. A. A. F. B. E. - D. M. A. W. N. N. A. L. D. A. I. Mostafa-Hedeab G, Sayed AboBakr Ali AH, W. N. A. Ahmed AF, Bahaa El-Deen MA, and A. L. DA, Idebenone regulates sirt1/Nrf2/TNF-α pathway with inhibition of oxidative stress, inflammation, and apoptosis in testicular torsion/detorsion in juvenile rats, , 2022.
Zhong, G., P. Ahimaz, N. A. Edwards, J. J. Hagen, C. Faure, Q. Lu, P. Kingma, W. Middlesworth, J. Khlevner, M. ElFiky, et al., "Identification and validation of candidate risk genes in endocytic vesicular trafficking associated with esophageal atresia and tracheoesophageal fistulas", Human Genetics and Genomics Advances, vol. 3, no. 3, pp. 100107, 2022. AbstractWebsite

Summary Esophageal atresias/tracheoesophageal fistulas (EA/TEF) are rare congenital anomalies caused by aberrant development of the foregut. Previous studies indicate that rare or de novo genetic variants significantly contribute to EA/TEF risk, and most individuals with EA/TEF do not have pathogenic genetic variants in established risk genes. To identify the genetic contributions to EA/TEF, we performed whole genome sequencing of 185 trios (probands and parents) with EA/TEF, including 59 isolated and 126 complex cases with additional congenital anomalies and/or neurodevelopmental disorders. There was a significant burden of protein-altering de novo coding variants in complex cases (p = 3.3 × 10−4), especially in genes that are intolerant of loss-of-function variants in the population. We performed simulation analysis of pathway enrichment based on background mutation rate and identified a number of pathways related to endocytosis and intracellular trafficking that as a group have a significant burden of protein-altering de novo variants. We assessed 18 variants for disease causality using CRISPR-Cas9 mutagenesis in Xenopus and confirmed 13 with tracheoesophageal phenotypes. Our results implicate disruption of endosome-mediated epithelial remodeling as a potential mechanism of foregut developmental defects. Our results suggest significant genetic heterogeneity of EA/TEF and may have implications for the mechanisms of other rare congenital anomalies.

van Unen, V., L. F. Ouboter, N. Ali, M. Schreurs, T. Abdelaal, Y. Kooy-Winkelaar, G. Beyrend, T. Höllt, J. P. W. Maljaars, L. M. Mearin, et al., "Identification of a Disease-Associated Network of Intestinal Immune Cells in Treatment-Naive Inflammatory Bowel Disease.", Frontiers in immunology, vol. 13, pp. 893803, 2022. Abstract

Chronic intestinal inflammation underlies inflammatory bowel disease (IBD). Previous studies indicated alterations in the cellular immune system; however, it has been challenging to interrogate the role of all immune cell subsets simultaneously. Therefore, we aimed to identify immune cell types associated with inflammation in IBD using high-dimensional mass cytometry. We analyzed 188 intestinal biopsies and paired blood samples of newly-diagnosed, treatment-naive patients (=42) and controls (=26) in two independent cohorts. We applied mass cytometry (36-antibody panel) to resolve single cells and analyzed the data with unbiased Hierarchical-SNE. In addition, imaging-mass cytometry (IMC) was performed to reveal the spatial distribution of the immune subsets in the tissue. We identified 44 distinct immune subsets. Correlation network analysis identified a network of inflammation-associated subsets, including HLA-DRCD38 EM CD4 T cells, T regulatory-like cells, PD1 EM CD8 T cells, neutrophils, CD27 TCRγδ cells and NK cells. All disease-associated subsets were validated in a second cohort. This network was abundant in a subset of patients, independent of IBD subtype, severity or intestinal location. Putative disease-associated CD4 T cells were detectable in blood. Finally, imaging-mass cytometry revealed the spatial colocalization of neutrophils, memory CD4 T cells and myeloid cells in the inflamed intestine. Our study indicates that a cellular network of both innate and adaptive immune cells colocalizes in inflamed biopsies from a subset of patients. These results contribute to dissecting disease heterogeneity and may guide the development of targeted therapeutics in IBD.

El-Salamouny, S., J. Wennmann, R. Kleespies, K. Richert-Pöggeler, and Mans, "Identification of a new nucleopolyhedrovirus isolated from the olive leaf moth, Palpita vitrealis, from two locations in Egypt ", Journal of Invertebrate Pathology, vol. 192, 2022.
Hussein, M. E., O. G. Mohamed, A. M. El-Fishawy, H. I. El-Askary, A. S. El-Senousy, A. A. El-Beih, E. S. Nossier, A. M. Naglah, A. A. Almehizia, and A. Tripathi, "Identification of Antibacterial Metabolites from Endophytic Fungus Aspergillus fumigatus, Isolated from Albizia lucidior Leaves (Fabaceae), Utilizing Metabolomic and Molecular Docking Techniques", Molecules, vol. 27, issue 3: MDPI, pp. 1117, 2022. Abstract
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Elshalofy, A., K. Wagener, K. Weber, M. Blanco, S. Bauersachs, and H. Bollwein, "Identification of genes associated with susceptibility to persistent breeding-induced endometritis by RNA-sequencing of uterine cytobrush samples", Reproductive biology, vol. 22, issue 2, pp. 100577, 2022.