Hepatitis C Virus (HCV) is a widely spread viral infection that affects millions of people worldwide. Liver cirrhosis and Hepatocellular Carcinoma have very strong link to liver viruses B and C. Sofosbuvir is a newly FDA approved drug (Dec. 2013) that acts against the spread of HCV. It is a Non-Structural 5B (NS5B) RNA dependent RNA polymerase (RdRp) Nucleoside Inhibitors (NI). Sofosbuvir is an anti-HCV drug among different compounds (e.g. IDX-184, R7128, etc.) that were under clinical trials for years.