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2021
Muhammed, H. Z., E. A. eLsherpieny, and E. M. Almetwally, " Dependency Measures For New Bivariate Models Based on Copula Function", Information Sciences Letters, An International Journal, vol. 10, issue 3, pp. 511 - 526, 2021.
application/pdf icon100316.pdf
Amin, K. M., D. E. Abdel-Rahman, H. A. Allam, and H. H. El-Zoheiry, " Design and synthesis of novel coumarin derivatives as potential acetylcholinesterase inhibitors for Alzheimer’s disease", Bioorg. Chem. , vol. 110, pp. 104792, 2021.
Ammal M. Metwally1, L. E. 12 S. A. E. D. 3 M. A. 2 A. M., H. Yousof, M. M. Elkholy, L. A. Eletreby, A. B. A., S. A. E. M. Dayem, M. Abdelrahman, and S. M. Eldeeb, " Determinants Influencing Awareness and Healthy Practices among a Sample of Insulin-dependent Diabetic Egyptian Patients: A Rural Community-based Study", Open Access Macedonian Journal of Medical Sciences, vol. 9, issue E, pp. 500- 508, 2021.
OS, H., K. MM, K. IM, and M. HS, " Development of a new Python- based cardiac phantom for myocardial SPECT imaging. ", Ann Nucl Med., vol. 35, issue 1, pp. 47-58, 2021.
, DOUBLE IMMUNOHISTOCHEMICAL EXPRESSION OF FAK AND PCNA IN ODONTOGENICKERATOCYST, ORTHOKERATINIZEDODONTOGENIC CYST, DENTIGEROUS CYST AND GLANDULAR ODONTOGENIC CYST, , 2021.
, DOUBLE IMMUNOHISTOCHEMICAL EXPRESSION OF FAK AND PCNA IN ODONTOGENICKERATOCYST, ORTHOKERATINIZEDODONTOGENIC CYST, DENTIGEROUS CYST AND GLANDULAR ODONTOGENIC CYST, , 2021.
elhafez, H. M., S. A. A. Badr, M. A. Abdelghany, S. S. Rezallah, and M. K. Tekla, " Efficacy of compressive ischemic pressure release on pectoral’s trigger points on RT side cardiac output following open heart surgery: Randomized Clinical Trial", Turkish Journal of Physiotherapy and Rehabilitation, vol. 32, issue 3, pp. 8725-8729, 2021.
Elsharnouby, M. H., Mohsen, J., O. T. Saeed, and A. A. Mahrous, " Enhancing resilience to negative information in consumer-brand interaction: the mediating role of brand knowledge and involvemen", t. Journal of Research in Interactive Marketing., 2021.
El-Shalofy, A., and M. Hedia, " Exogenous oxytocin administration improves the testicular blood flow in rams", Andrologia, vol. 53, issue 10, pp. e14193, 2021.
Al-Sayed, S. R., and D. Youssef, " Exploiting Local Contrast Laser Speckle Photography for Surface Topometry of Laser Metal Deposition", Optics InfoBase Conference Papers, 2021.
Gamal-AbdelNaser, A., E. Ahmed, M. Zakaria, and S. Gaafar, " How Difficult is it for Patients Having Oral Ulcers to Get Diagnosed? ", Int. J. Odontostomat, vol. 15, issue 4, pp. 823-826, 2021.
Rashad, E., S. Hussein, D. W. Bashir, Z. S. O. Ahmed, and H. El-Habback, " Immunohistochemical Distribution of Immunocompetent Cells in Water Buffalo Spleen (Bubalus bubalis). ", Journal of Advanced Veterinary Research, vol. 11, issue 1, pp. 24-35, 2021.
Rashad, E., S. Hussein, D. W. Bashir, Z. S. O. Ahmed, and H. El-Habback, " Immunophenotyping Panel of T Lymphocyte in Water Buffalo Spleen (Bubalus Bubalis) And Its Significant Correlation to Ruminant Diseases ", Journal of Advanced Veterinary Research, vol. 11, issue 2, pp. 57-63, 2021.
and Heba A Gad1, M A Khalaf2, H. A. 2 Z. A. M. 2, "" Indoor air quality of commercial broiler farms affecting humeral immune response against field IBV vaccine ", • j.Egypt.vet.med.Assoc. , vol. 81, issue 1, pp. 81-97, 2021. lbhth_10_lshr.pdf
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A.Salim, S., S. A. Loutfy, E. M.El-Fakharany, T. H.Taha, Y. Hussien, and E. A.Kamoun, " Influence of chitosan and hydroxyapatite incorporation on properties of electrospun PVA/HA nanofibrous mats for bone tissue regeneration: Nanofibers optimization and in-vitro assessment", Journal of Drug Delivery Science and Technology, vol. 62, pp. , 2021. Abstract

This study targets to develop curcumin-loaded polyvinyl alcohol/cellulose nanocrystals (PVA/CNCs) membrane as localized delivery system for breast/liver cancer. A novel strategy was developed for enhancing encapsulation capacity and maximizing therapeutic efficiency of curcumin-loaded PVA/CNCs membranes. Membranes were prepared by solution-casting method using citric acid as crosslinker. SEM revealed that PVA/CNCs ratio (80:20) was chosen as the optimum for loading curcumin. FT-IR indicated that, curcumin was incorporated into PVA/CNCs in amorphous-phase via intermolecular hydrogen bond between curcumin and membrane components. Curcumin showed biphasic-release through burst-release of 41% of curcumin during the first hour, followed by sustained-release of 70% and 94% during 24 h and 48 h, respectively. In vitro cytotoxicity of PVA/CNCs/Curcumin membrane exhibited a selective inhibition proliferation of breast and liver cancer cells in a concentration-dependent without any toxic effect on normal cells. At high concentration (8 mg/ml) of PVA/CNCs/Curcumin, reduced viability to 35% and 7% of MCF-7 and Huh-7 cells, respectively; meanwhile high HFB-4 normal cell viability ≥80% was investigated. Antimicrobial activity of PVA/CNCs/Curcumin was investigated by multi-drug-resistant strains, and MIC values. PVA/CNCs/Curcumin membranes with concentration (40 mg/ml) showed broad-spectrum antimicrobial activities, thus inhibited ~96-99% of microbial growth. PVA/CNCs/Curcumin membranes could be as promised anti-infective biomaterials for breast and liver cancer wound healing.

Hafez, R. S., R. Ramadan, and S. S. El-khiyami, " Investigation of structural, optical, magnetic, and electrical properties of PMMA doped with magnetite nanoparticles", J .Mater. Sci.- Mater. Electron., vol. 32, pp. 14557-14568, 2021.
Emam, S. R., A. - E. R. M., Azouz, A. A., Ali, El Badawy, S. A., M. A. Ibrahim, Hassan, M. Y. Issa, and S. H. Elmosalamy, " Linum usitatissimum seeds oil down-regulates mRNA expression for the steroidogenic acute regulatory protein and CYP11A1 genes, ameliorating letrozole-induced polycystic ovarian syndrome in a rat model", J Physiol Pharmacol, vol. 72(1), pp. 55-67, 2021.
Ramadan, H. M., H. H. Ahmed, and N. A. Taha, " Melatonin enhances antioxidant defenses but could not ameliorate the reproductive disorders in induced hyperthyroidism model in male rats.", Environmental science and pollution research , 2021. ramadan2021_article_correctiontomelatoninenhancesa.pdf
Abdou, D. M., A. A. Mohamed, M. Abdulhay, and S. El Khateeb, Mitochondrial Complex I Deficiency among Egyptian Pediatric Patients with SteroidResistant Nephrotic Syndrome. , , Cairo, 2021.
Hassan, A. S., E. A. Elsherpieny, and S. A. Eltaweel, " New Topp Leone-G Family with Mathematical Properties and Applications ", Journal of Physics: Conference Series , pp. 1 -9 , 2021.
application/pdf iconhassan_2021_j._phys.__conf._ser._1860_012011.pdf
Ali, S. A. El Badawy, Elmosalamy, S.H., Emam, S. H., Azouz, A. A., Galal, H., R. M. Abd-Elsalam, M. Y. Issa, and B. B. Hassan, " Novel Promising Reproductive and Metabolic Effects of Cicer arietinum L. Extract on Letrozole Induced Polycystic Ovary Syndrome in Rat Model ", Journal of Ethnopharmacology,, vol. 278, pp. 114318, 2021.
Zaher, G. K., M. F. Shaaban, M Mokhtar, and H. H. Zeineldin, " Optimal operation of battery exchange stations for electric vehicles", Electric Power Systems Research, vol. 192, pp. 1-11, 2021.
Hassan, M. A., and M. A. M. Ismail, " PERSPECTIVES ON TOLERANCE TO PARASITIC INFECTIOUS DISEASES ", J. Egypt. Soc. Parasitol. (JESP), vol. 51, issue 3, pp. 485-492, 2021. Abstract

Immune responses to infectious parasitic diseases appear to be simply directed towards kill-
ing or clearing the parasite. However, the immunological strategies constitute a complex inco-
rporated network of immune mechanisms to eradicate the parasite itself in addition to preser-
vation of the integrity of host tissues. Resistance and tolerance are believed to be two distinct
complementary host defense immune strategies. Mechanisms triggering infectious tolerance to
parasitic infections are still poorly recognized but seem to be centered on controlling parasite-
induced tissue damage in the infected host. It is becoming obvious that realizing infectious tol-
erance as a prominent constituent of defense strategy deliver significant conceptions in coex-
istence of host-parasite relationship. This data may also pave the way to new therapeutic app-
roaches in many parasitosis.
Key words: Immune response, Tolerance, Parasitic infections, Resistance, Review

S.B.Mahmoud, M.K.Anwar, O.G.Shaker, and D.A.ElSharkawy, " Possible Relation between Vitamin D and Interleukin-17 in the Pathogenesis of Lichen Planus.", Dermatology, vol. 237, issue 6, pp. 896-901, 2021.
Eid, E. M., H. M. E. Hassaneen, S. A. Loutfy, and T. Salaheldin, " Preparation of pyrimido[4,5-b][1,6]naphthyridin-4(1H)-one derivatives using a zeolite–nanogold catalyst and their in vitro evaluation as anticancer agent", Journal of Chemical Research, vol. 15, pp. , 2021. Abstract

This study targets to develop curcumin-loaded polyvinyl alcohol/cellulose nanocrystals (PVA/CNCs) membrane as localized delivery system for breast/liver cancer. A novel strategy was developed for enhancing encapsulation capacity and maximizing therapeutic efficiency of curcumin-loaded PVA/CNCs membranes. Membranes were prepared by solution-casting method using citric acid as crosslinker. SEM revealed that PVA/CNCs ratio (80:20) was chosen as the optimum for loading curcumin. FT-IR indicated that, curcumin was incorporated into PVA/CNCs in amorphous-phase via intermolecular hydrogen bond between curcumin and membrane components. Curcumin showed biphasic-release through burst-release of 41% of curcumin during the first hour, followed by sustained-release of 70% and 94% during 24 h and 48 h, respectively. In vitro cytotoxicity of PVA/CNCs/Curcumin membrane exhibited a selective inhibition proliferation of breast and liver cancer cells in a concentration-dependent without any toxic effect on normal cells. At high concentration (8 mg/ml) of PVA/CNCs/Curcumin, reduced viability to 35% and 7% of MCF-7 and Huh-7 cells, respectively; meanwhile high HFB-4 normal cell viability ≥80% was investigated. Antimicrobial activity of PVA/CNCs/Curcumin was investigated by multi-drug-resistant strains, and MIC values. PVA/CNCs/Curcumin membranes with concentration (40 mg/ml) showed broad-spectrum antimicrobial activities, thus inhibited ~96-99% of microbial growth. PVA/CNCs/Curcumin membranes could be as promised anti-infective biomaterials for breast and liver cancer wound healing.