Publications

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2006
Hemayed, E. E., "Surface Extended Polar Map (SEPMap): An Orientation-independent, Scale Invariant Surface Representation Scheme for Surface Matching", The Seventh Annual U.A.E. University Research Conference, UAE, Citeseer, 2006. Abstract

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A.M.Attallah, A. T. Abbas, M. I. Dessouky, H. M.El-emshaty, and H. M.Elsheikha, "Susceptibility of neonate mice born to Schistosoma mansoni-infected and noninfected mothers to subsequent S. mansoni infection", Parasitol Res. , vol. 19, pp. 137-145 , 2006.
Y, Y., S. E, I. M, D. T, G. M, and E. - M. F, "Sympathetic Overactivity in Cirrhotic Patients in Relation to Cardiovascular and Renal Changes.", Egyptian heart journal, vol. 58, issue 3, pp. 573-583, 2006.
Elmahdy, H. N., and M. A. Moneim, "Synchronization of Arabic Closed Captioning with Sign Language", The Egyptian Computer Science Journal, vol. 28, issue 1, pp. 41-49, 2006.
El-Fattah, B. A., M. M. Kandeel, O. M. Khalil, and A. S. M. A. A. E. KASSAB, "synthesis and antibacterial activity of fused thienopyrimidine derivatives", Al-Azhar Journal of Pharmaceutical Sciences, vol. 34, pp. 64-76, 2006.
Ragab, F. A. E. - F., N. M. Eid, G. S. Hassan, and Y. M. Nissan, "Synthesis and anticonvulsant activity of new 4-thiazolidinones and 2-thioxo-4-imidazolidinones attached to 4-oxo and thioxobenzopyranes", Bull. Fac. Pharm. Cairo Univ, vol. 44, issue 3, pp. 83-93, 2006.
Ragab, F. A. E. - F., N. M. Eid, G. S. Hassan, and Y. M. Nissan, "Synthesis and anticonvulsant activity of new 4-thiazolidinones and 2-thioxo-4-imidazolidinones attached to 4-oxo and thioxobenzopyranes.", Bull. Fac. Pharm. Cairo Univ.,, vol. 44, issue 3, pp. 89-93, 2006.
Ragab, F. A., H. M. Safwat, M. M. Hussein, N. A. - E. M. Gawad, and G. S. Hassan, "Synthesis and anticonvulsant activity of thiazolidin-4-one derivatives carrying a furochromone or benzofuran moiety", Bull. Fac. Pharm. Cairo Univ.,, vol. 44, issue 3, pp. 71-82, 2006.
Abdallah, M. A., S. M. Riyadh, I. M. Abbas, and S. M. Gomha, "Synthesis and Antimicrobial Activity of 3,5-Disubstituted-1,3,4-thiadiazol-2-yliden by the Intramolecular Ring Transformation of 1,3,4-Oxadiazole", International Journal of Pure and Applied Chemistry, vol. 1, pp. 265-271, 2006.
Abdelrazek, F. M., P. Metz, N. H. Metwally, and S. F. El-Mahrouky, "Synthesis and molluscicidal activity of new cinnoline and pyrano[2,3-c]pyrazole derivatives.", Arch. Pharm. Chem. life Sciences (Weinheim), vol. 339, issue 8, pp. 456-460., 2006.
F. M. Abdelrazek, F. A. Michael, and A. E. Mohamed, "Synthesis and molluscicidal activity of some 1,3,4-triaryl-5-chloropyrazole, pyrano[2,3- c]pyrazole, pyrazolylphthalazine and pyrano[2,3-d]thiazole derivatives.", Arch. Pharm. Chem. life Sciences (Weinheim), vol. 339, issue 6, pp. 305-312, 2006.
Abdou O. Abdelhamid, O. S. Abo-Team, and A. A. Al-Atoom, "Synthesis and reactions of [5-amino-4-(4-(2-thienyl)(1,3-thiazol-2-yl))pyrazol-3-yl]phenylamine", Chemistry An Indian J., vol. 3, pp. 61, 2006.
Abdelhamid, A. O., A. H. El-Ghandour, S. A. Ahmed, and Y. H. Zaki, "Synthesis and reactivity of 2-Chloro-2-(hydroximino)-1-4-methyl-2-phenyl)thiazol-5-yl-1-one.", J. Heterocyclic Chem., vol. 43, pp. 249 , 2006.
Zayed, M. A., N. F. A. El-Dien, G. G. Mohamed, and N. E. A. El-Gamel, "Synthesis and thermal characterization of new ternary chelates of piroxicam and tenoxicam with glycine and dl-phenylalanine and some transition metals.", Spectrochimica Acta, Part A 64, 216-232, 2006.
Abadi, A. H., S. M. Abou-Seri, D. E. Abdel-Rahman, C. Klein, O. Lozach, and L. Meijer, Synthesis of 3-substituted-2-oxindole analogues and their evaluation as kinase inhibitors, anticancer and antiangiogenic agents, , 2006. Abstract

Several analogues of the 3-substituted-2-oxoindole chemotype were synthesized by condensing isatin or the appropriate haloisatin with some amino acids or histamine under neutral conditions. All the imino derivatives produced were tested for kinase inhibitory properties against three serine/threonine kinases, namely CDK1/cyclin B, CDK5/p25 and GSK3α/β. Most of the histidine derivatives showed inhibitory properties to the three kinases in the low micromolar range. The histamine derivatives were less potent against CDK1/cyclin B and CDK5/p25 and totally inactive against GSK3α/β. So, the management of the carboxyl function may be a tool to impart selectivity in such family of kinases. Docking of 2-{[-5-bromo-2-oxoindolin-3-ylidene]amino}-3-(1H-imidazol-2-yl)propanoic acid 14 to CDK5/p25 indicates that this compound can interact with the enzyme through four hydrogen bonds; for GSK/3β, the ligand poses itself in another orientation, also four hydrogen bonds can be formed between the ligand and the receptor, otherwise hydrophobic interactions seem to predominate. Also, all the final compounds were tested for their in vitro antitumor properties against MCF7 (breast), NCI-H460 (lung) and SF268 (CNS) cancer cell lines. None of the synthesized compounds was cytotoxic at 10–4 molar concentration. Moreover, compounds 13 and 14 were tested for potential antiangiogenic properties by testing their ability to inhibit the proliferation of human umbilical vein endothelial cells (HUVECs), cord formation and migration in response to chemoattractant. Only compound 14 showed moderate inhibitory properties to HUVECs proliferation and cord formation while its non-brominated derivative 13 did not. Thus, the antiangiogenesis properties are not apparently caused by inhibition of any of the tested kinases.

Abadi, A. H., S. M. Abou-Seri, D. E. Abdel-Rahman, and C. Klein, "Synthesis of 3-substituted-2-oxoindole analogues and their evaluation as kinase inhibitors, anticancer and antiangiogenic agents", European Journal of Medicinal Chemistry , vol. 41 , pp. 296–305, 2006.
Abdel-Fattah, B., M. M. Kandeel, M. Abdel-Hakeem, and Z. M. Fahmy, "Synthesis of Certain Fused Thienopyrimidines of Biological Interest", Journal of Chinese Chemical Society, vol. 53, issue 2, pp. 403-412, 2006.
Sayed, N. E. A., N. A. Afifi, and G. M. Kamel, "Synthesis of certain new condensed pyrimidines as potential anticonvalsant agents", Bull. Fac. Pharm. Cairo Univ., vol. Vol. 44, issue No, 3(3), pp. 59- 69, 2006.
Sayed, N. E. A., N. A. Afifi, and G. M. Kamel, "Synthesis of certain new condensed pyrimidines as potential anticonvalsant agents. ", Bull. Fac. Pharm. Cairo Univ., vol. 44,, issue 3(3), pp. 59- 69 , 2006.
Mahmoud, R. A., S. Botros, A. K. El-Ansary, and M. M. Kamel, "Synthesis of certain substituted Pyridazines and pyrimido[4,5-c]pyridazines of anticipated antimicrobial activity", Bulletin of Faculty of Pharmacy, Cairo University, vol. 43, issue 3, pp. 35-41, 2006. my_master_paper.pdf